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Ozempic shows anti-aging effects in trial

trial.medpath.com

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Re: Ozempic shows anti-aging effects in trial

#351

Post by glp1guide »

chhxdjsj wrote: post #338
glp1guide wrote: post #286

If you think Ozempic (Semaglutide) is good, Retatrutide is going to blow it out of the water: https://glp1.guide/content/a-new-glp1-retatrutide/ Currently the only people experimenting with it are the underground gray market peptide enthusiasts (you can find them on reddit and elsewhere), but the results are quite intense. [EDIT] Just to be clear, gray market Retatrutide is illegal, I'm not encouraging you to buy it…

Why use something which appears to have very similar results to tirzepatide/mounjaro but hasn’t been used by tens of millions on people without obvious issues like tirzep?

Well there's no reason, except it's even more effective.

And 100%, using Retatrutide right now is illegal/not a good idea. It is super risky.

That said, anecdata from people with that risk tolerance is certainly worth looking at.

Re: Ozempic shows anti-aging effects in trial

#352

Post by cm2187 »

nosignono wrote: post #84
matwood wrote: post #68

Earlier quoted context omitted.

And not just weight loss, but the people I know on GLP-1's have also significantly cut back on alcohol. I think there are ongoing trials around GLP-1's and general addiction.

I find my compulsion towards videogames is decreased. Not eliminated, but I feel much less compelled to be playing all the time.

That may be a correlation without causation. Don't know if you lost much weight, but if you did, a huge benefit of losing weight is to increase the level of tonus, and suddenly activities that require no tonus (playing video games, watching TV) become less compelling relatively to other activities.

Re: Ozempic shows anti-aging effects in trial

#353

Post by aorloff »

aianus wrote: post #334
mbac32768 wrote: post #306

Earlier quoted context omitted.

The skepticism people have towards metabolic dysregulation models of obesity is too much. We know for a fact the inverse happens: girl starves herself for years to slim down to become a ballerina, eventually decides it's not worth it and tries to stop being so dangerously thin and... can't. She never feels hungry. Every time she eats she can only stomach a few bites before pushing it away. Just eat ice cream? Instant…

Is there a drug I can take to gain weight?

Its called sugar

Re: Ozempic shows anti-aging effects in trial

#354

Post by verisimi »

radiofreeeuropa wrote: post #173
throwawaylaptop wrote: post #142

Earlier quoted context omitted.

I helped my dad lose 50 lbs by finally, after 10 years, getting him to give up bread, sugar, potatoes. It took buying him 2 months of a bluetooth glucose monitor. Once he saw what certain foods do, he believed me finally. At 65 years old, healthier than I remember since he was 40 and I was a teen. It doesn't require some weird injection.

There's anecdotes, and there's science. Individually, there's (previously) been nothing better to suggest than "try harder (and, maybe, smarter)". Statistically it was almost useless, but it's the best we had. It's not bad advice exactly, it's just extremely unlikely to work for long-term, sustained weight loss. It also very much appears to be the case that weight gain and loss are heavily influenced by environmental…

> There's anecdotes, and there's science.

> If your solution to the obesity crisis is "people need to try harder" your solution is demonstrably not helpful. Can it work for one person? Yes. Over a population, will it? No

Are you an individual or a population though? Take off the telescopes (and data, and science), and look at the world through your own eyes.

No one needs (or can) to address the obesity crisis in the population. The only crises that can be solved are the ones individuals find in themselves.

Re: Ozempic shows anti-aging effects in trial

#355

Post by chilldsgn »

p1dda wrote: post #290

Please stop with these obvious pharma ads, nobody needs to take Ozempic! Change your lifestyle and most importantly: STOP EATING JUNK FOOD

It really puzzles me how people would just pop a pill instead of make some lifestyle changes. Maybe it's just my personality type, but it disturbs me how most people just want something quick and easy instead of doing the actual work and becoming overall better via a real learning journey by struggling through changing bad habits.

But whatever, they do whatever works for them! I don't like pharma.

Re: Ozempic shows anti-aging effects in trial

#356

Post by imtringued »

42772827 wrote: post #256
nradov wrote: post #253

Earlier quoted context omitted.

I don't understand. What's sad about giving up junk carbs?

Bread, sugar and potatoes exist on a spectrum from highly processed/refined (truly problematic) to minimally processed whole food versions (nutritionally valuable). There's no reason to give up minimally processed whole food versions of these.

There is no spectrum for me. I can't eat bread or sugar.

Re: Ozempic shows anti-aging effects in trial

#357

Post by imtringued »

parineum wrote: post #198
throwawaylaptop wrote: post #183

Earlier quoted context omitted.

If you told millions of people that bread, sugar, pasta and bread are basically killing them, and to flat out stop eating them.. you probably would help people lose weight (and save many lives too). My dad has finally understood that grains are for people that need help maintain weight or gaining weight. No fat person should ever be eating them.

If I told you billions of people eat bread, sugar and pasta and it wasn't "basically killing them" (whatever that means)... It's strange to make the culprit of a modern epidemic foods that have been with us for millenia.

Modern wheat is a very modern invention. You have to be pretty gullible to believe that something that has only existed for 50 years has existed for millennia.

Re: Ozempic shows anti-aging effects in trial

#358

Post by strken »

some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

"No free lunch" is a reasonable question to ask when evaluating medication, if it would improve the evolutionary fitness of the majority of people. I think this is behind some of the skepticism. If Ozempic is so great then how come our bodies don't just produce more GLP-1? How come we aren't like chimps, with eternally shredded bodies and cheese grater abs, provided we get the protein to support them?

I would guess that getting fat in times of plenty was a feature and not a bug in the ancestral environment, and that's why we get fat today, which is obvious if you think about it. Still, it means GLP-1 agonists are smacking into quick "is it bullshit?" heuristics for a lot of people.

The second point I haven't seen discussed is that weight loss drugs prior to GLP-1 agonists include cigarettes, which (worst case) give you cancer; stimulants, which cause your heart to fail; parasitic intestinal worms, which can kill you but more importantly are just plain gross; and mitochondrial uncouplers, which set you on fire at a cellular level. That's a long history of miracle weight loss drugs which turn out to have horrible side effects. It's not reasonable to think GLP-1 is bad just because of other drugs with different mechanisms, but it certainly causes some skepticism anyway.

Re: Ozempic shows anti-aging effects in trial

#359

Post by ducksinhats »

aianus wrote: post #334
mbac32768 wrote: post #306

Earlier quoted context omitted.

The skepticism people have towards metabolic dysregulation models of obesity is too much. We know for a fact the inverse happens: girl starves herself for years to slim down to become a ballerina, eventually decides it's not worth it and tries to stop being so dangerously thin and... can't. She never feels hungry. Every time she eats she can only stomach a few bites before pushing it away. Just eat ice cream? Instant…

Is there a drug I can take to gain weight?

I don't want you to consider it among the flippant replies here but definitely alcohol will work up to a point, it's somewhat of a contradiction though because severe alcoholics are usually quite malnourished and thin.

Re: Ozempic shows anti-aging effects in trial

#360

Post by vidarh »

verisimi wrote: post #354
radiofreeeuropa wrote: post #173

Earlier quoted context omitted.

There's anecdotes, and there's science. Individually, there's (previously) been nothing better to suggest than "try harder (and, maybe, smarter)". Statistically it was almost useless, but it's the best we had. It's not bad advice exactly, it's just extremely unlikely to work for long-term, sustained weight loss. It also very much appears to be the case that weight gain and loss are heavily influenced by environmental…

> There's anecdotes, and there's science. > If your solution to the obesity crisis is "people need to try harder" your solution is demonstrably not helpful. Can it work for one person? Yes. Over a population, will it? No Are you an individual or a population though? Take off the telescopes (and data, and science), and look at the world through your own eyes. No one needs (or can) to address the obesity crisis in the…

And odds are very firmly that you'll fail. That's what the science shows us.
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