Israel’s Covid-19 boosters are preventing infections, new studies suggest • Hacker News Board

Re: Israel’s Covid-19 boosters are preventing infections, new studies suggest

#351

Post by vfclists » Fri, Sep 03, 2021, 9:12 PM UTC

bondarchuk wrote: post #98

hackingforfun wrote: post #73

I'm pretty surprised to still see some misinformation in some of the posts here. I have a friend who has a PhD in molecular biology and she described the mRNA vaccines to me. The mRNA is only a piece of the spike protein, and does not enter the cell's nucleus. It only interacts with the cytoplasm. Normally, if a cell had to deal with an actual SARS-CoV-2 virus, it would be dealing with the spike proteins and the enti…

The amount of times I've seen text to the extent of "mRNA does not alter DNA" vastly exceeds the amount of text I've seen that claims mRNA does alter DNA. As far as I could see nobody in this thread is claiming such a thing, so I'm genuinely curious to know why you feel the need to point it out.

What is this paper saying then?

SARS-CoV-2 RNA reverse-transcribed and integrated into the human genome

https://pubmed.ncbi.nlm.nih.gov/33330870/

Re: Israel’s Covid-19 boosters are preventing infections, new studies suggest

#352

Post by ac2u » Fri, Sep 03, 2021, 11:08 PM UTC

dukeofdoom wrote: post #335

disgruntledphd2 wrote: post #312

Earlier quoted context omitted.

I don't know, but lots of people seem to claim this (without citations).

"This study demonstrated that natural immunity confers longer lasting and stronger protection against infection" https://www.medrxiv.org/content/10.1101/2021.08.24.21262415v...

Ah, I was thinking it was that paper.

This is the conclusion, pasted:

>This study demonstrated that natural immunity confers longer lasting and stronger protection against infection, symptomatic disease and hospitalization caused by the Delta variant of SARS-CoV-2, compared to the BNT162b2 two-dose vaccine-induced immunity. Individuals who were both previously infected with SARS-CoV-2 and given a single dose of the vaccine gained additional protection against the Delta variant.

So two things:

1) The vaccine still helps those even with acquired natural immunity. 2) The study is comparing the vaccine targeted towards the original Wuhan variant against a moving target.

So I don't see why we should discount vaccines and rely on natural immunity when we can still update the vaccines to join the fight against new strains and collect more data.

Obviously there's still great value in this study in perhaps justifying delaying doses for people who've had a previous infection in order to get more equitable distribution of vaccines.

Re: Israel’s Covid-19 boosters are preventing infections, new studies suggest

#353

Post by xattt » Sun, Sep 05, 2021, 6:04 PM UTC

lm28469 wrote: post #287

xattt wrote: post #8

I am fascinated to know what the effects are of over-vaccination. Is there some spillover effects where a highly-primed immune system begins to get into weird autoimmune reactions? Do weird plaques develop or a build-up of antibodies begin to form in random parts of the body, like in a blood dyscrasia? Or does nothing happen? Chronic vaccine overdoses are so exotic, as access to vaccines had been historically so tigh…

> Do weird plaques develop > build-up of antibodies begin to form in random parts of the body Real curious: do these things exist in the first place ? Plaques of what ? Where in the body ? I've never heard of antibody build up and google neither apparently

The thing that comes to mind are leukaemia cutis, cutaneous b-cell lymphoma and POEMS syndrome.

(1) https://dermnetnz.org/topics/skin-manifestations-of-haematol...

Re: Israel’s Covid-19 boosters are preventing infections, new studies suggest

#354

Post by Grakel » Wed, Sep 08, 2021, 3:30 AM UTC

zaptrem wrote: post #348

SamPatt wrote: post #329

Earlier quoted context omitted.

The government is not meant to be majority rule. It was explicitly created to prevent majority rule. The Senate acted as a longer term, more stable body to counteract the more popularist House. Originally citizens didn't even vote for Senators, they were appointed by the states themselves. An entire set of explicit rules restrained what the majority could do (Constitution and Bill of Rights). Majority rule has a long…

lemmie guess... “America isn’t a democracy, it’s a republic” https://www.theatlantic.com/ideas/archive/2020/11/yes-consti... “The government wasn’t meant to fulfill the will of the people... it was meant to fulfill the will of my people!” Minority rule has a much longer and more gruesome history of abuses, and it never ends well for the rulers.

What a straw man argument in that article. "not a democracy" simply refers to avoiding decisions based on the public opinion that sways in the wind, sometimes dramatically. See vaccine and mask mandates.