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Ozempic shows anti-aging effects in trial

trial.medpath.com

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Re: Ozempic shows anti-aging effects in trial

#341

Post by bethekind »

glp1guide wrote: post #286

If you think Ozempic (Semaglutide) is good, Retatrutide is going to blow it out of the water: https://glp1.guide/content/a-new-glp1-retatrutide/ Currently the only people experimenting with it are the underground gray market peptide enthusiasts (you can find them on reddit and elsewhere), but the results are quite intense. [EDIT] Just to be clear, gray market Retatrutide is illegal, I'm not encouraging you to buy it…

If Eli Lily is the only producer, how is the gray market being supplied? This makes no sense...

That being said, I'm waiting for oral GLP1 agonists. Injections are a hassle and gray market ones even more so

Re: Ozempic shows anti-aging effects in trial

#342

Post by recursive »

drcode wrote: post #304
p1dda wrote: post #290

Please stop with these obvious pharma ads, nobody needs to take Ozempic! Change your lifestyle and most importantly: STOP EATING JUNK FOOD

But junk food is fun: Maybe we can eat junk food, have fun in life, and still be reasonably healthy, with the help of science (and if glps don't work well enough to allow this, then maybe the next medicine in the pipeline)

The drug just makes you eat less.

Re: Ozempic shows anti-aging effects in trial

#343

Post by glp1guide »

toomuchtodo wrote: post #291
glp1guide wrote: post #286

If you think Ozempic (Semaglutide) is good, Retatrutide is going to blow it out of the water: https://glp1.guide/content/a-new-glp1-retatrutide/ Currently the only people experimenting with it are the underground gray market peptide enthusiasts (you can find them on reddit and elsewhere), but the results are quite intense. [EDIT] Just to be clear, gray market Retatrutide is illegal, I'm not encouraging you to buy it…

What's the difficulty level of obtaining Retatrutide through non traditional channels?

It's completely illegal -- the drug is not for sale, obviously is not FDA approved, and is not manufactured anywhere, the only safe/legal way to get it is a via an ongoing trial:

https://trials.lilly.com/en-US/trial/580035

As one might imagine though, capitalism found a way. A LOT of compounding pharmacies are now very good at manufacturing GLP1s (not necessarily the case that the knowledge transfers, but I imagine networks/knowledge sharing groups do), so gray market has sprung up to supply adventurous people with Retatrutide.

Re: Ozempic shows anti-aging effects in trial

#344

Post by tortilla »

aianus wrote: post #334
mbac32768 wrote: post #306

Earlier quoted context omitted.

The skepticism people have towards metabolic dysregulation models of obesity is too much. We know for a fact the inverse happens: girl starves herself for years to slim down to become a ballerina, eventually decides it's not worth it and tries to stop being so dangerously thin and... can't. She never feels hungry. Every time she eats she can only stomach a few bites before pushing it away. Just eat ice cream? Instant…

Is there a drug I can take to gain weight?

mj

Re: Ozempic shows anti-aging effects in trial

#345

Post by cm2187 »

mikaraento wrote: post #313
matwood wrote: post #68

Earlier quoted context omitted.

And not just weight loss, but the people I know on GLP-1's have also significantly cut back on alcohol. I think there are ongoing trials around GLP-1's and general addiction.

Definitely lowered alcohol consumption for me. I no longer get that dopamine rush of the first drink. Some people go as far as describing it as anhedonia. I kinda get it.

Not for me, in fact my diet involed not taking any dessert, which GLP1 made fairly easy, so I ended up allowing myself to drink a couple of glasses of wine in the evening, which I never did before. I never noticed an alteration of the sense of taste, just a general feeling of satiety (particularly on an empty stomach).

Though many people mention feeling sick as a common side effects, I can very well imagine that they would lose any pleasure from food and drink.

Re: Ozempic shows anti-aging effects in trial

#347

Post by johncolanduoni »

nomel wrote: post #172
hinkley wrote: post #124

Earlier quoted context omitted.

You've got a crowd of people raised in a Calvinist society who think nothing good comes without suffering, you've got people who feel this is a cheat where discipline should win out, and you have a bunch of people who are used to all easy solutions coming with either a bad lottery ticket or externalities on other people/the environment. They can all agree that they're waiting for the other shoe to drop. That said, we…

> Calvinist society who think nothing good comes without suffering Or, some of us older folks have been around long enough to understand that we are, in an uncontroversial and factual way, the long term medical trial, and long term effects found in that trial, along with the eventual market withdrawal, may not show up until 10 to 20 years later, creating a healthy distrust in the money/corporations behind the, someti…

How many times has a drug had negative effects that only showed up after 10-20 years? Out of all the drugs that have been widely prescribed in, say, the last 100 years? And it’s not even actually a new drug class - Liraglutide was approved in 2010! Should we wait until the clinical trial participants all die of old age until we put a drug on the market?

Re: Ozempic shows anti-aging effects in trial

#348

Post by andsoitis »

aianus wrote: post #334
mbac32768 wrote: post #306

Earlier quoted context omitted.

The skepticism people have towards metabolic dysregulation models of obesity is too much. We know for a fact the inverse happens: girl starves herself for years to slim down to become a ballerina, eventually decides it's not worth it and tries to stop being so dangerously thin and... can't. She never feels hungry. Every time she eats she can only stomach a few bites before pushing it away. Just eat ice cream? Instant…

Is there a drug I can take to gain weight?

Weight from muscle? Or from fat?

Re: Ozempic shows anti-aging effects in trial

#349

Post by glp1guide »

bethekind wrote: post #341
glp1guide wrote: post #286

If you think Ozempic (Semaglutide) is good, Retatrutide is going to blow it out of the water: https://glp1.guide/content/a-new-glp1-retatrutide/ Currently the only people experimenting with it are the underground gray market peptide enthusiasts (you can find them on reddit and elsewhere), but the results are quite intense. [EDIT] Just to be clear, gray market Retatrutide is illegal, I'm not encouraging you to buy it…

If Eli Lily is the only producer, how is the gray market being supplied? This makes no sense... That being said, I'm waiting for oral GLP1 agonists. Injections are a hassle and gray market ones even more so

> If Eli Lily is the only producer, how is the gray market being supplied? This makes no sense...

It turns out enterprising chemists and pharmacists are capable of reverse engineering.

I don't think it's that hard to figure out how someone might do it -- imagine having to reverse engineer food you've received, given many samples. Imagine some of those samples might have "fallen off the back of a truck".

> That being said, I'm waiting for oral GLP1 agonists. Injections are a hassle and gray market ones even more so

This is really going to be the second leg of adoption and will catapult GLP1s even further IMO. Rybelsus has not really seen a ton of popularity compared to the injections. That said, Orforglipron is Eli Lilly's upcoming oral GLP1 and it looks to have really good results:

https://glp1.guide/content/updates-from-maritide-orforglipro...

Re: Ozempic shows anti-aging effects in trial

#350

Post by readthenotes1 »

pie_flavor wrote: post #114
readthenotes1 wrote: post #44

Earlier quoted context omitted.

I have no idea why you're down voted. The replication crisis is real, and it is well known that fraud is a part of it

Because it's a content-free dismissal. No attempt is made to link it to this study in particular.

If the poster had said

"given the replication crisis and outright fraud endemic in scientific publications these days, I have little faith that this research will bear fruit for the general population"

Would that have been specific enough?

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