Earlier quoted context omitted.
Hard to say. Since you're a finger in the Hand, I guess the palm would tell you to fold.
..when in comes the EU, who have successfully penalized and stared down Facebook, Intel, Apple and Microsoft. And which is either the biggest (until the Brits have officially left) or the third biggest economy in the world. You can't simply ignore them, even as a company of Google or Apple's size.
EU rules prevents EU members from dealing directly with a part of a EU member so no negociation are possible with any member of the UK until brexit.
Let's see if the scottish referendum happens...