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Peptides: where to begin?

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Re: Peptides: where to begin?

#311

Post by gruez »

EiZei wrote: post #218
arjie wrote: post #213

I used retatrutide for weight loss and went from 199.3 lbs to just under 175 lbs. I kept daily notes through the process. Here's a quick AI one-paragraph summary if you're curious: https://pastebin.com/XACNYKvs Overall I'm quite pleased with the effects and many of the properties of this treatment that people dislike are actually properties I was looking for. Essentially, for pharmacological interventions I want impe…

> Rough cost for the retatrutide is $1.25/mg. Even with free healthcare that seems like a foolish place to save money when very widely used alternatives exist in the regulated market.

>when very widely used alternatives exist in the regulated market.

Which ones? Semiglutide costs orders of magnitude more.

Re: Peptides: where to begin?

#312

Post by steveBK123 »

throwaway2037 wrote: post #241
steveBK123 wrote: post #238

I think we are sort of in the worst of both worlds right now re: medicines/supplements/gray market. FDA approval is expensive slow process. Doctors train for a long time and then work 40+ years entire careers, some without a ton of continuing education. But then we have an entire gray market because enough legal and practical loopholes to drive a freight train through, such that people are self medicating with dubiou…

> some without a ton of continuing education. Where did you get this idea? I did a simple, five second Google search and learned that on average, US doctors are required to complete about 50 hours of continuing education for each one- to two-year recert cycle. (On HN, I also hear similar complaints about public school teachers. It isn't true. Public school teachers are required to do similar continuing education.)

Mandate vs interest.

Compare how seriously many SWEs take mandatory HR/compliance trainings vs hanging out on HN, taking online courses, arguing about code, trying new frameworks, coding in spare time, etc.

Re: Peptides: where to begin?

#313

Post by ifyoubuildit »

mapontosevenths wrote: post #286
ifyoubuildit wrote: post #245

Earlier quoted context omitted.

"Antivaxxer*" here. I'm not injecting peptides for a similar reason - I'm not convinced the cost/benefit works out. That said, the issue for many is autonomy - if you want to put novel stuff in your body, go ahead. As long as you don't try to compel me to do it. * Not if we're actually in literate company, but that seemed to be the common consensus after I skipped the jab, having recovered from covid right before the…

> That said, the issue for many is autonomy Your right to swing a fist ends where the other fella's nose begins. That doesn't mean you aren't free, it just means you recognize that the right not to suffer grievous bodily harm trumps the right to swing your fist willy-nilly. As a fist-swinger you may not always agree, and you may even get hurt one day because you couldn't swing your fist whenever you wanted, but that'…

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Re: Peptides: where to begin?

#314

Post by cjbgkagh »

Angostura wrote: post #149
cjbgkagh wrote: post #65

Peptides are a revolution and you don't need to know how they work to know that they work (for various people for various conditions). There is a tension between empiricism and fundamentalism with much of medical science focusing on fundamentalism. Now with the ability to collect and search large amounts of empirical data and communicate it peer-to-peer people are picking up on a lot of things that work without knowi…

> you don't need to know how they work to know that they work Welcome to the powerful world of the placebo

Placebos would work with anything with a plausible story, since I’ve tried many hundreds of things and only a handful worked I’m highly confident that it’s not a placebo. People with ME/CFS are used to trying things and have them not work so the placebo effect where it exists has usually worn off.

Re: Peptides: where to begin?

#315

Post by cjbgkagh »

deinonychus wrote: post #130
cjbgkagh wrote: post #65

Peptides are a revolution and you don't need to know how they work to know that they work (for various people for various conditions). There is a tension between empiricism and fundamentalism with much of medical science focusing on fundamentalism. Now with the ability to collect and search large amounts of empirical data and communicate it peer-to-peer people are picking up on a lot of things that work without knowi…

can you talk about how semaglutide improves ME?

I don’t know the mechanism, I think ME/CFS is an autoimmune condition and semiglutide appears to help with autoimmune conditions in general. That was my reason for trying it. The improvements snuck up on me after many months as I noticed I was having fewer and fewer bad days.

Re: Peptides: where to begin?

#316

Post by cjbgkagh »

dev_l1x_be wrote: post #162
cjbgkagh wrote: post #65

Peptides are a revolution and you don't need to know how they work to know that they work (for various people for various conditions). There is a tension between empiricism and fundamentalism with much of medical science focusing on fundamentalism. Now with the ability to collect and search large amounts of empirical data and communicate it peer-to-peer people are picking up on a lot of things that work without knowi…

Have you tried omega3? There were some improvements I was reading about.

I have tried everything on just about every list of possible treatments, having been in the fortunate position to have made enough money that I can try things full time and being able to bypass doctors for access to medicine and being able to do my own research.

Re: Peptides: where to begin?

#317

Post by cjbgkagh »

deng wrote: post #192
cjbgkagh wrote: post #65

Peptides are a revolution and you don't need to know how they work to know that they work (for various people for various conditions). There is a tension between empiricism and fundamentalism with much of medical science focusing on fundamentalism. Now with the ability to collect and search large amounts of empirical data and communicate it peer-to-peer people are picking up on a lot of things that work without knowi…

> There is a tension between empiricism and fundamentalism with much of medical science focusing on fundamentalism. This is a deeply unfair statement, and also a false dichotomy. Medical science is of course empiric. What you call "fundamentalism" is that compounds need to undergo a rigorous regiment of empiric testing before they are given to potentially millions of people. And no, it's not just because of Thalidomi…

Doctors have been maligning ME/CFS as psychosamatic for decades and generally still do despite a large amount of modern evidence to the contrary. If you have it it’s clearly not, you can get good and bad days that are clearly not dependent on psychological state. In addition I have it due to hEDS which is a condition that is almost never diagnosed due to aforementioned blind spots. Most doctors still think the prevalence rate is 1/50K despite continued research raising that number to 1/15K and 1/500. It takes a long time for this information to percolate through the system.

Doctors, like many professions, have institutional blind spots, I studied these in my search because I was looking for something that had not been found. Most doctors have to consider all people and all conditions, I only have to be concerned with one.

Notably they only recently adopted Bayesian statistics for medical trials despite that math being around for hundreds of years.

Re: Peptides: where to begin?

#318

Post by Jerrrrrrrry »

rootusrootus wrote: post #101
olalonde wrote: post #57

Earlier quoted context omitted.

You lost muscle because you lost around 1.54% of body weight per week, which is way too aggressive. The maximum recommended amount for losing weight while retaining muscle is around 1%. You will also most likely experience a weight rebound.

Hasn't this mostly been debunked? You lose muscle mass because you lost mass overall, and whether you lost it too quickly or not is not the major factor. AFAIK maintaining muscle mass while losing fat is borderline impossible for anyone who isn't extremely fat and/or very disproportionate composition to begin with.

GLP1 destroy muscle tissue.

Re: Peptides: where to begin?

#319

Post by cjbgkagh »

coryrc wrote: post #284
bertylicious wrote: post #131

Earlier quoted context omitted.

I'm pretty sure there is no diagnostic test for ME/CFS. What are you referring to? Also I don't understand how semaglutide did help you while you're at the same time part of a minority risk group with a hypersensitivity to it. Isn't that a contradiction?

Doesn't it just mean GP needs to take less?

Yes, sensitivity at over 10x normal, so I just took 10x less. I’m taking a more normal dose now after 4 years and I believe I have become desensitized as my body normalized. Other seemingly unrelated aspects also normalized such as thyroid, testosterone, and neutrophils also improved. I was taking medication for these and have been able to stop taking them. I am assuming a lack of GLP1-As to begin with caused the receptors become more sensitive to it. When I started there was no anecdotal information available just theory, in the 4 years since many people have now had very similar experiences including hypersensitivity. (https://www.healthrising.org/blog/2025/11/03/glp-1-agonist-m...)

Re: Peptides: where to begin?

#320

Post by Jerrrrrrrry »

heurist wrote: post #143

I'm not inclined to be a guinea pig for these. I suspect maybe later in my child's life they will have been proven long-term safe (or not). I'll be old or dead at that point. I'm really wary of putting anything not known to be standard food or medicine into my body.

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