Scientists may have found mechanism behind cognitive decline in aging • Hacker News Board

Re: Scientists may have found mechanism behind cognitive decline in aging

#311

Post by xtracto » Mon, Jul 31, 2023, 2:26 PM UTC

codethief wrote: post #119

swalsh wrote: post #16

I've noticed a cognitive decline in myself the past couple years. I'm in my mid 30's though so I assume it's more related to long covid. One of the biggest side effects of long covid for me was horrible insomnia, which was killer. The insomnia is mostly gone, but I'm still not my previous cognitive self. It's terrifying to be honest.

Have you noticed a change in your breathing due to covid?

Not OP but I had terrible covid at 38y old around march 2020. My chest xray showed one of my lungs was really bad , and during 3 months I was feeling like crap (includingthe brain fog and all the stuff people mention).

Fast forward 3 years, I go swimming thrice a week, and it sucks that STILL my breathing hasn't recovered. If I try to take a lot of air for several times, I'll start coughing. I get out of air quickly... even though I have strength to keep swimming.

Re: Scientists may have found mechanism behind cognitive decline in aging

#312

Post by dillydogg » Wed, Aug 02, 2023, 4:16 PM UTC

herval wrote: post #280

dillydogg wrote: post #147

Earlier quoted context omitted.

Telomeres are just repeats at the end of chromosomes to allow for replication. They aren't directly involved in replication fidelity beyond allowing for replication to proceed. I guess protecting genes near chromosome termini but that's different than the mutations you would expect in cancer.

my understanding is cancer gets more prevalent when the telomeres get old (short?), since it leads to more mutations/botched replication?

I'm sorry for the delay, but this actually isn't quite right. Short telomere syndromes are not associated with cancer. In fact, it is long telomeres that have a strong association with cancer (largely because aberrantly activating telomerase can drive cancer development.)

https://pubmed.ncbi.nlm.nih.gov/22965356/ for more on short telomere syndromes.

Re: Scientists may have found mechanism behind cognitive decline in aging

#313

Post by fao_ » Wed, Aug 09, 2023, 4:57 PM UTC

esperent wrote: post #198

fao_ wrote: post #83

Earlier quoted context omitted.

There's a large amount of precedence, that's why. Rather than asking the room, one would think the first step would be to obtain information and inform yourself. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753965/ https://pubmed.ncbi.nlm.nih.gov/34022259/ https://theconversation.com/natural-supplements-can-be-dange...

Why so defensive? I'm asking the room because it's a smart room, usually, and often there's someone who'll be far better informed than I could be with a quick search. That's literally why I spend time here. Regarding your links, I'm sure I could find similar studies about nearly any kind of food. I have a friend who won't eat peanuts because he's afraid of aflotoxins, which are real, genuinely dangerous, and if you t…

"These things are also contaminated" is shoddy argumentative reasoning at best, it is not the "got ya" that you think it is . I never claimed that there aren't contaminants in food, and I don't see how it defeats my claim that dietary supplements are unsafe -- the FDA is more stringent in regulation and testing with respect to food, as opposed to dietary supplements, because, you know, we need to eat to survive.

Please take a second to read my comment here, before responding: https://news.ycombinator.com/item?id=36930128

Re: Scientists may have found mechanism behind cognitive decline in aging

#314

Post by fao_ » Wed, Aug 09, 2023, 4:58 PM UTC

mynameisvlad wrote: post #249

fao_ wrote: post #94

Earlier quoted context omitted.

I clearly made a point of inquiring why the behaviour was performed, it was an honest inquiry, I am genuinely curious. For what it is worth, my context is that I have seen the behavior of asking the room, or even just throwing out conjecture to the room, without properly doing research beforehand, to be a common flaw within computer scientists and within "tech workers" as a demographic. I had to put up for a whole ye…

> taking care to be polite If what you consider “polite”, several people call out as aggressive, then maybe you should re-evaluate your definition of the word. Your comment does not read polite. At best, passive aggressive. Asking questions fosters discussion. For a site centered around discussion, that seems warranted. Telling people to just look it up is pretty much the antithesis of discussion.

> Telling people to just look it up is pretty much the antithesis of discussion.

On the contrary, the quality of discussion would be much higher if people took one entire minute beforehand to research something. It is shameful and disappointing that the techbros here cannot be bothered to do this, and prefer to live in ignorance.