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Vaccine hopes rise as Oxford jab prompts immune response among old and young

reuters.com

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Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#311

Post by krustyburger »

mcv wrote: post #260
eumenides1 wrote: post #170

Earlier quoted context omitted.

The point is that we should reconsider giving (temporary) monopolies to companies that are based public research. I suggest that we should give merek the for profit monopoly, but allow for non profit manufacturing. If another organization wants to make the vaccine but not derive profit from the process, let them. Manufacturing takes time and money to develop. Revenue should pay for those costs. The non-profit gains e…

Exactly. The idea that the public funds research, but corporations can monopolies the results of that research for profit, is just disgusting. Non-exclusive deals are fine. Exclusive ones not, at least not within the country/countries that funded it; they already paid for it, and denying them access is basically theft.

Drug companies also fund their own research, to the tune of massive expenditures. What you’re suggesting would incentive these companies to disengage from partnerships involving public funding. Whoever pays for the research, each company’s goal is to profitably sell a non-generic treatment. If the only way they can do that is to eschew public funds, they will do this and the result will be less cooperation and a far reduced ability for the government to influence the direction of private sector research, and more importantly shape private sector manufacturing and the quantities of specific treatments supplied to the market.

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#312

Post by mromanuk »

Bobblebobble wrote: post #303

I'm in the trial. Here's the participant information sheet, in case anyone's curious: https://drive.google.com/file/d/1WB5QPmECchlThnem9wcX0PDaKQW...

at what point you know (or will know) if you were given a placebo or the actual vaccine?

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#313

Post by d0ugal »

nickcotter wrote: post #152

Good news but still a long way to go. How's it going to be rolled out? Here in the UK we have tried and failed to get a regular flu jab (our GPs have run out of a very small supply and the pharmacies don't have any to sell) and I'm not optimistic about our chances of getting this next year or whenever it arrives.

I was able to get the flu jab easily in Scotland (as was my wife and my daughter is getting it tomorrow). It was incredibly well organised.

I think if you are unlucky it can be hard to get, but it is rolling out fast and many people are thankfully able to get it.

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#314

Post by coldpie »

dougweltman wrote: post #306
ageitgey wrote: post #69

A quick summary of were the Oxford vaccine stands since it's hard to follow: - When will the vaccine be ready? After the Phase 3 efficacy data is reported, assuming that the data shows that the vaccine prevents COVID or reduces COVID severity. This happens after enough people in the trial get sick with COVID. Then they unblind the groups and see if the people who got sick were in the control group or the vaccinated g…

>Early on, one person got symptoms consistent with typical vaccine side effects, but it was determined that the person had a previously undiagnosed, unrelated disease. Second, there was the highly publicized case where a patient suffered temporary spinal inflammation and recovered shortly. It is unclear if this event is related to the vaccine, ... This seems rather worrying as these Phase 1 and Phase 2 trials are pre…

This is exactly the kind of question the trials are designed to answer, yes. We know roughly the background incidence rate of diseases, so you can expect some percentage of participants will be affected by those diseases. It's also important to remember your basic statistics fallacies: the question is not, what are the odds that any of our participants come down with MS, which is a very tiny chance. The question is, what are the odds that any of our participants will come down with _any_ background disease, which is a much larger chance. It is very likely to happen, and indeed it does. They still pause the study to run the numbers and make sure the new diagnoses are not outliers from the background rate.

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#315

Post by soulofmischief »

uxcolumbo wrote: post #86
soulofmischief wrote: post #26

Earlier quoted context omitted.

> in particular, but not limited to, the brain Judging from our response to Covid-19, if this had actually been the collectively-feared zombie virus, the pandemic would have been far worse than any fictional account has manage to capture so far.

How so? World War Z Walking Dead Shawn of the Dead * 28 Days Later The Last of Us What's worse than the above? * (ok maybe not this one)

As science fiction is speculative, I do not fault any of those listed media however I feel none of them truly captured the sociopolitical insanity that would occur, the sheer level of ignorance and incompetence which causes anything that could go wrong, to go wrong.

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#316

Post by garmaine »

mromanuk wrote: post #312
Bobblebobble wrote: post #303

I'm in the trial. Here's the participant information sheet, in case anyone's curious: https://drive.google.com/file/d/1WB5QPmECchlThnem9wcX0PDaKQW...

at what point you know (or will know) if you were given a placebo or the actual vaccine?

when the trial is ended.

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#317

Post by guptaneil »

vxNsr wrote: post #286
komali2 wrote: post #220

Earlier quoted context omitted.

> What is the alternative? We create a government agency that specializes in manufacturing and distributing pharma products? Yes. Why don't you think that would work?

Because the government hasn't been able to do anything right for 270 years, why do you think they're suddenly gonna wake up a figure out mass manufacturing? We can't educate our kids at an acceptable level without billions of dollars being donated on top of all the tax collected, we can't figure out how to make medicare work responsibly despite literally being able to control costs, what do you think makes drug manuf…

In the US, one party has dedicated itself to making sure the government is dysfunctional for a _long_ time so that it can run on the platform that government doesn’t work and we should privatize everything. This is not a fact of nature, it’s a willful decision. For example, the US used to be a leader in education. The thing that changed since then is one party started defunding education and moving that money to private prisons and defense.

If we as a people collectively agreed that we are as smart as other countries, there’s no reason we can’t have a functional government that can handle public education and vaccine efforts and keep us safe and maintain our infrastructure and everything else we expect our government to do for us.

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#318

Post by [deleted] »

komali2 wrote: post #220
leemcalilly wrote: post #215

Earlier quoted context omitted.

This is not corrupt. It’s money well spent. The benefits to us all are most likely more valuable than anything we’ve spent on vaccine research. Government balance sheets also probably come out ahead on that investment given that the alternative is an economy with a raging pandemic and resulting lower tax base. Then there is the logistical effort of manufacturing the vaccine at the scale and speed required. There are…

> What is the alternative? We create a government agency that specializes in manufacturing and distributing pharma products? Yes. Why don't you think that would work?

[deleted]

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#319

Post by erikrothoff »

Bobblebobble wrote: post #303

I'm in the trial. Here's the participant information sheet, in case anyone's curious: https://drive.google.com/file/d/1WB5QPmECchlThnem9wcX0PDaKQW...

Are you given any monetary compensation or compensation at all for joining the trial?

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#320

Post by mcv »

faitswulff wrote: post #33
dbetteridge wrote: post #3

OK, someone tell me why this isn't the good news it sounds like

Well, it's still good news, but an injected vaccine may not lead to sterilizing immunity - i.e. vaccinated persons might still be able to transmit the disease: > Without a strong mucosal response, injected vaccines may be less likely to produce so-called sterilizing immunity, a phenomenon in which a pathogen is purged from the body before it’s able to infect cells, Dr. Durbin said. Vaccinated people might be protecte…

Even so, reducing the severity would be great. Even if a patient doesn't die, Covid-19 can have devastating and long-lasting effects. If a vaccine could reduce it to just a mild flu, I think that's good enough. You just have to inject everyone and probably add it to the standard child vaccination set.
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