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Vaccine hopes rise as Oxford jab prompts immune response among old and young

reuters.com

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Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#161

Post by lordnacho »

senko wrote: post #76
ageitgey wrote: post #69

A quick summary of were the Oxford vaccine stands since it's hard to follow: - When will the vaccine be ready? After the Phase 3 efficacy data is reported, assuming that the data shows that the vaccine prevents COVID or reduces COVID severity. This happens after enough people in the trial get sick with COVID. Then they unblind the groups and see if the people who got sick were in the control group or the vaccinated g…

Thank you for volunteering and putting your health on the line for the benefit of us all. Even if the risk is small, it takes courage. I'm assuming you also don't know if you got the active substance or a placebo?

> I'm assuming you also don't know if you got the active substance or a placebo?

You don't want to bias the study by revealing that information. People who knew whether they'd gotten the real thing might behave differently.

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#162

Post by jmull »

marketingPro wrote: post #2

This article reinforces that herd immunity between young healthy people would have been the best solution. Our old are going to get sick from vaccines, so the young are going to get it anyway. Next year under 50 year olds will line up for their vaccine. Meanwhile 1.5 years worth of old, obese, and sick people will have died from coronavirus. Wouldn't it have been better if healthy kids and adults caught it in q2 2020…

> Wouldn't it have been better if healthy kids and adults caught it in q2 2020?

No.

We have one population. There's no way to segment it to allow people at low risk to catch the virus without also allowing people at high risk to get it.

How do you think it could work otherwise?

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#163

Post by impendia »

Jemm wrote: post #112
impendia wrote: post #90

Earlier quoted context omitted.

Various experts are predicting that the winter will be quite bad. See for example: https://covid19.healthdata.org/global?view=infections-testin... https://covid19.healthdata.org/united-states-of-america?view... But notice, in the latter chart, that in the US the number of infections is predicted to peak in January and then start going down. It seems plausible that by March, we'll achieve some level of herd immunity,…

Those charts are already inaccurate. I wouldn't rely on them.

Rely on them? I agree, certainly not. But at least they describe a plausible scenario.

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#164

Post by strictnein »

kuu wrote: post #110
calvinv wrote: post #32

Earlier quoted context omitted.

if we're back to normalish by spring next year I think that would be a great outcome, if the messaging to the public would be, buckle down until then I think lockdown complaince could go up

Let's see, because the vaccination probably requires two shots per person with probably 6-8 months in between, so it will take time...

Where did you read 6-8 months between? I’ve just seen the timespan between shots be listed as 1 month almost everywhere.

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#165

Post by _Microft »

bufferoverflow wrote: post #143
apexalpha wrote: post #134

Earlier quoted context omitted.

Who cares. I'd gladly give this company a couple of billion if it means they can get us back to normal. Oxford develops the vaccine with public money. We also, god willing, need to manufacture billions of them and transport them around the globe. For that manufacturing, give me a solid existing multinational with a proven manufacturing record and base please, not some non-profit startup.

I care. Just like about the bailouts. Socializing the funding/losses and privatizing the profits is just pure corruption.

The nominal world economy 'GDP' was $90T in 2019 [0]. An economic contraction of 5% because of the pandemic would mean a loss of $4500B. If a vaccine helps to avoid that, even a cost of dozens of billion dollars for it would be peanuts in comparison. This is only the economic cost avoided let alone the human tragedies.

Edit: german Wikipedia suggest that the contraction is only expected to be 3% but because of the numbers involved even that doesn't really matter for the argument.

[0] https://en.wikipedia.org/wiki/World_economy

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#166

Post by benlumen »

nickcotter wrote: post #152

Good news but still a long way to go. How's it going to be rolled out? Here in the UK we have tried and failed to get a regular flu jab (our GPs have run out of a very small supply and the pharmacies don't have any to sell) and I'm not optimistic about our chances of getting this next year or whenever it arrives.

I think you might be surprised. The government knows that this is the silver bullet they need to rescue the economy from oblivion.

I’m expecting that once this thing is ready there’ll be a logistical effort for the history books to roll it out. See what they can do with the military involved, like the nightingales.

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#168

Post by [deleted] »

xiphias2 wrote: post #39
aphextron wrote: post #14

Earlier quoted context omitted.

>OK, someone tell me why this isn't the good news it sounds like The AstraZeneca vaccine is based on an adenovirus vector, which has never been approved for use in humans. It uses a weakened live virus that can (and apparently has, in the case of the J&J vaccine, which is using very similar tech) cause serious adverse systemic reactions. From what we've seen so far, the safety profile for these vaccines is far worse…

Thanks for your input! The worrying trend is the ,,signed contracts with governments'' part even though the clinical trial results are not out yet. It seems that vaccination gets highly political, just like how EU made a mistake of paying for Remdesivir even though we knew that it's not worth it at that point.

[deleted]

Re: Vaccine hopes rise as Oxford jab prompts immune response among old and young

#170

Post by eumenides1 »

apexalpha wrote: post #134
zoobab wrote: post #116

Good news for US BigPharma Merck holding the Oxford patents, while public funding has paid for its research: https://archive.is/aGUJd

Who cares. I'd gladly give this company a couple of billion if it means they can get us back to normal. Oxford develops the vaccine with public money. We also, god willing, need to manufacture billions of them and transport them around the globe. For that manufacturing, give me a solid existing multinational with a proven manufacturing record and base please, not some non-profit startup.

The point is that we should reconsider giving (temporary) monopolies to companies that are based public research.

I suggest that we should give merek the for profit monopoly, but allow for non profit manufacturing. If another organization wants to make the vaccine but not derive profit from the process, let them.

Manufacturing takes time and money to develop. Revenue should pay for those costs. The non-profit gains experience, but no profit. The for-profit gains profit. If the for-profit decides to raise prices too high, there will be a willing and capable competitor waiting in the wings.

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