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High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset
31–40 of 54 posts
Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset
#32I've tried taking vitamin D bc heard it was so great. After taking 1000 ui a day for a week or two, I will start to experience mood issues like increased anger and anxiety which will go away after a couple days of stopping. I have heard of others with this complaint as well, but I do not know why. ChatGPT suggests something about magnesium and calcium levels, but it's certainly not a commonly talked about side effect…
Curious.
Could you please share your physical activity level around the time of supplementation?
One of the most interesting studies I found in my research of vitamin D was a study in an elder care center where the patients were given massive doses of vitamin D.
The result of the massive doses were that patience had less hip fractures, but more falls compared to the control.
Now take this next part with a grain of salt because it’s me extrapolating from this result, but due to the known effects of vitamin D on muscle strength and also on bone density, I imagine that these patients were more active, but because vitamin D doesn’t give you coordination as well as strength they were falling more, their bones were more dense so they had less fractures per fall.
The point I’m trying to make and the reason I am curious about your own activity level, is that perhaps that there is a sensation or feeling of your muscles being more primed for action which can be agitating. Perhaps regular activity can link one’s sense of proprioception with increased muscular ability.
Apologies in advance if this is too personal of a pry.
Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset
#33I’ve been toying with idea of upping vitamin D Iu. Currently its 1000 and that was what was prescribed to me a while back.
I take 5000 daily as a maintenance dose. Bloodwork has been basically perfect since I started doing that. If you are deficient doctors often prescribe a massive daily dose like 20000-30000 to get back to normal then drop down to a maintenance dose. The nice thing with vitamin D is that you can actually check its level in bloodwork. The normal range is often considered to be between 50-125 ng/mL with below 30 consider…
Muscle cramps/spasms are a lot more than just vitamin D.. electrolytes are important.. If they have been deficient in vitamin D, chances are they are also deficient in electrolytes as well.
Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset
#34I've tried taking vitamin D bc heard it was so great. After taking 1000 ui a day for a week or two, I will start to experience mood issues like increased anger and anxiety which will go away after a couple days of stopping. I have heard of others with this complaint as well, but I do not know why. ChatGPT suggests something about magnesium and calcium levels, but it's certainly not a commonly talked about side effect…
When does a professional come into play? You assumed you're deficient, you asked chatgpt, and now you're asking for anecdotes from HN. Go get some blood work done and talk to a professional who actually knows about these things.
It's shocking to me when people openly claim to have used chatgpt for advice on something as important as this.
Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset
#35I've tried taking vitamin D bc heard it was so great. After taking 1000 ui a day for a week or two, I will start to experience mood issues like increased anger and anxiety which will go away after a couple days of stopping. I have heard of others with this complaint as well, but I do not know why. ChatGPT suggests something about magnesium and calcium levels, but it's certainly not a commonly talked about side effect…
Curious. Could you please share your physical activity level around the time of supplementation? One of the most interesting studies I found in my research of vitamin D was a study in an elder care center where the patients were given massive doses of vitamin D. The result of the massive doses were that patience had less hip fractures, but more falls compared to the control. Now take this next part with a grain of sa…
I run 3-5 times a week but otherwise pretty sedentary.
Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset
#36Earlier quoted context omitted.
I thought follow up work also showed it's questionable whether dietary vitamin D actually has any of the benefits that you get through solar vitamin D?
Yes, 90% of the world’s population does not absorb dietary vitamin D well, which should make people skeptical of this result.
Nonesense. It's well established that dietary D3 (or D2, but D3 is better) clearly incleases 25(OH)D serum levels. It is that serum biomarker whose deficiency (levels below 20ng/ml or 30ng/ml) that has the largest association with higher risk of dozens of diseases as well as all-cause mortality. You can defend your phrasing by saying that "not well" just means one has to take a lot of it. Yes, there is a wide variety of dose response, which is why it's best to test blood levels to titrate supplementation amount.
Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset
#37Earlier quoted context omitted.
Not sure why you're being downvoted, so I created an account specifically to respond. I've had the same issue. Even when I take low doses of 400iu, vitamin D causes extreme anxiety and mood issues that only go away a couple of days after I stop taking it. I've had to completely cut it out and can't take supplements that contain it. I've also taken various brands so I would assume the additives would be different but…
Out of curiosity, the various brands, were any of them in liquid form? The reason I ask is because it's possible to be intolerant or allergic to one of the filler ingredients in a tablet.
No, they weren't, and that's a good suggestion that I need to try.
Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset
#38Earlier quoted context omitted.
I don't think there's an easy answer as we all have differently tuned bodies with different known/unknown beningn/malevolent conditions. It's probably good to do some short term experimenting, try eating more magnesium and calcium rich foods and see how you feel. If you really want to be objective, get your blood contents measured. (Although blood levels don't show everything, like calcium stores in the bones.)
Yeah, experimentation makes sense. I've had it happen twice, with two different dosages. First time was at a higher dosage than 1000 and I think it happened sooner. I'm just calling it out here, because sometimes you get lucky and someone else had the same issue and has the answer and will resolve the mystery. I'm not saying Vit D is bad, I'm just curious if others have had difficulties with it. My doctors opinion on…
Never had/heard of your problem with Vitamin D.
A web search brings up - https://www.reddit.com/r/Biohackers/comments/1ia6yyb/update_...
tl;dr - some Vit D supplements are based on lanolin. if you're sensitive to it, you may switch to a supplement that doesn't use lanolin. also one response talks about taking a multi-Vitamin B supplement for anger issues with Vit.D
Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset
#39I've tried taking vitamin D bc heard it was so great. After taking 1000 ui a day for a week or two, I will start to experience mood issues like increased anger and anxiety which will go away after a couple days of stopping. I have heard of others with this complaint as well, but I do not know why. ChatGPT suggests something about magnesium and calcium levels, but it's certainly not a commonly talked about side effect…
I've experienced something similar and I believe D3 is not to blame.
I took 5k iu oil softgels and got a unique and indescribable BAD feeling. It crept up very gradually over the course of a month and a half and I had a hard time realizing what was happening. It took me over a month to recover after I stopped.
Another time I've taken 2k iu dry D3 and had zero side-effects.
A couple of years after that D3 mishap, I tried some omega-3 and after a two weeks I realized that that unique bad feeling was making a comeback.
Again, another time I tried a different brand of omega-3 I had no side-effects.
I have a bunch of food sensitivities. So I believe that was a reaction to some contaminants in the oil.
Re: High‑dose Vitamin D reduces disease activity in early multiple sclerosis onset
#40I’ve personally been taking 7500 IU daily for many years now. Anecdotally (yes, I know, N=1) I have noticed I get sick less. I just did the math and apparently I’m taking the same dose as the participants in this article. I firmly believe the RDA is wrong, and the “high dose” of this article is closer to what the RDA should be. I can’t find the article which caused me to originally start my 7500 IU regiment but there…
Did a masters on Vit D. Multiple overdoses of over 1 million IU have been recovered from without obvious long-term damage present in near term follow up. Out of vitamin D’s many potentially clinically positive effects some of the clearest and best evidence is for increased muscle strength. Personally I take between 5000-10000 IU D3 daily depending on exposure to sun intensity.
Care to share your thesis? Sounds interesting! What was your degreee in?