Earlier quoted context omitted.
And neither are they RS-232, unless you've got a transceiver (MAX232 etc) in there :) Man... USB CDC is painful. It's so much "fun" that a serious solution on one product was two back-to-back FTDI transceivers. I think they finally designed that out, but I'm scared to look at what might be in its place now....
https://www.tindie.com/products/8086net/usb-usb-null-modem-c... presented without comment
They are genuinely useful.