Ozempic shows anti-aging effects in trial • Hacker News Board

Re: Ozempic shows anti-aging effects in trial

#291

Post by toomuchtodo » Wed, Aug 06, 2025, 4:55 AM UTC

glp1guide wrote: post #286

If you think Ozempic (Semaglutide) is good, Retatrutide is going to blow it out of the water: https://glp1.guide/content/a-new-glp1-retatrutide/ Currently the only people experimenting with it are the underground gray market peptide enthusiasts (you can find them on reddit and elsewhere), but the results are quite intense. [EDIT] Just to be clear, gray market Retatrutide is illegal, I'm not encouraging you to buy it…

What's the difficulty level of obtaining Retatrutide through non traditional channels?

Re: Ozempic shows anti-aging effects in trial

#292

Post by homefree » Wed, Aug 06, 2025, 4:55 AM UTC

jjice wrote: post #139

matwood wrote: post #68

Earlier quoted context omitted.

And not just weight loss, but the people I know on GLP-1's have also significantly cut back on alcohol. I think there are ongoing trials around GLP-1's and general addiction.

I've heard similar for gambling, and as one of the sister comments said, things like video games. I'm so curious to understand _why_ that effect is there, but I've heard this so many times now that I do believe that it exists in some capacity. Such an interesting world we're opening up here.

My hypothesis is addiction is generally a secondary application of overeating. Getting pleasure from eating a surplus when you’re not hungry is adaptive (or at least was for most of human history).

In a lot of ways these other behaviors are similar, it wouldn’t shock me if it’s a shared underlying mechanism originally to encourage eating a calorie surplus.

Re: Ozempic shows anti-aging effects in trial

#293

Post by SchemaLoad » Wed, Aug 06, 2025, 4:59 AM UTC

loeg wrote: post #287

matwood wrote: post #68

Earlier quoted context omitted.

And not just weight loss, but the people I know on GLP-1's have also significantly cut back on alcohol. I think there are ongoing trials around GLP-1's and general addiction.

I've heard this as well, but (anecdotally) they haven't reduced my interest in alcohol at all.

Would you consider yourself addicted? Perhaps it stops the addiction without stopping the general desire to drink with friends.

Re: Ozempic shows anti-aging effects in trial

#294

Post by [deleted] » Wed, Aug 06, 2025, 5:00 AM UTC

toomuchtodo wrote: post #291

glp1guide wrote: post #286

If you think Ozempic (Semaglutide) is good, Retatrutide is going to blow it out of the water: https://glp1.guide/content/a-new-glp1-retatrutide/ Currently the only people experimenting with it are the underground gray market peptide enthusiasts (you can find them on reddit and elsewhere), but the results are quite intense. [EDIT] Just to be clear, gray market Retatrutide is illegal, I'm not encouraging you to buy it…

What's the difficulty level of obtaining Retatrutide through non traditional channels?

[deleted]

Re: Ozempic shows anti-aging effects in trial

#295

Post by anitil » Wed, Aug 06, 2025, 5:01 AM UTC

jsbg wrote: post #52

Doesn't biological age normally go down with weight loss? Is it just a corollary of the off-label effects of the drug?

I was wondering a similar thing - even as simple as wear-and-tear on your joints, hips and back is less as a smaller bodyweight. I notice I even look younger at a lower bodyweight (up to a point)

Re: Ozempic shows anti-aging effects in trial

#296

Post by Almondsetat » Wed, Aug 06, 2025, 5:02 AM UTC

42772827 wrote: post #235

throwawaylaptop wrote: post #142

Earlier quoted context omitted.

I helped my dad lose 50 lbs by finally, after 10 years, getting him to give up bread, sugar, potatoes. It took buying him 2 months of a bluetooth glucose monitor. Once he saw what certain foods do, he believed me finally. At 65 years old, healthier than I remember since he was 40 and I was a teen. It doesn't require some weird injection.

He could have lost all that weight and still had bread, sugar, and potatoes but instead he gave up what he clearly enjoyed. Now he gets to live out the rest of his life fighting cravings, telling himself he's not allowed to enjoy food. How utterly sad.

Who are you to know what's going on inside his head? What an arrogant comment

Re: Ozempic shows anti-aging effects in trial

#297

Post by ses1984 » Wed, Aug 06, 2025, 5:03 AM UTC

c4ptnjack wrote: post #216

throwawaylaptop wrote: post #185

Earlier quoted context omitted.

[flagged]

The zeitgeist has pushed the idea carbs/grains and sugar are terrible over the last 40 years on and off, so that seems to say more about the medical industrial complex, than anything. That's fair, but if that message has been pushed so consistently, why didn't we see a real decrease in the consumption of those things and the associated weight loss?

Because carbs taste great.

Re: Ozempic shows anti-aging effects in trial

#298

Post by _345 » Wed, Aug 06, 2025, 5:03 AM UTC

radiofreeeuropa wrote: post #173

throwawaylaptop wrote: post #142

Earlier quoted context omitted.

I helped my dad lose 50 lbs by finally, after 10 years, getting him to give up bread, sugar, potatoes. It took buying him 2 months of a bluetooth glucose monitor. Once he saw what certain foods do, he believed me finally. At 65 years old, healthier than I remember since he was 40 and I was a teen. It doesn't require some weird injection.

There's anecdotes, and there's science. Individually, there's (previously) been nothing better to suggest than "try harder (and, maybe, smarter)". Statistically it was almost useless, but it's the best we had. It's not bad advice exactly, it's just extremely unlikely to work for long-term, sustained weight loss. It also very much appears to be the case that weight gain and loss are heavily influenced by environmental…

Then what should I do :(

Re: Ozempic shows anti-aging effects in trial

#299

Post by anitil » Wed, Aug 06, 2025, 5:04 AM UTC

some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

I see a similar hesitancy around anti-alcohol addition treatments like naltrexone. People almost _want_ it to be difficult to quit (or lose weight), like there should be some moral struggle associated with it

Re: Ozempic shows anti-aging effects in trial

#300

Post by SchemaLoad » Wed, Aug 06, 2025, 5:04 AM UTC

Aurornis wrote: post #111

noah_buddy wrote: post #20

Earlier quoted context omitted.

Many people (will only speak to America), view being fat as a literal moral failing. Gluttony or overeating are not the sin, but being fat. (From that perspective:)a miracle cure that allows someone to stop being fat is like an indulgence (in the Roman Catholic sense). It’s a cheat, a shortcut that allows the unworthy to reach a state they do not deserve. My opinion is to wait long enough to validate there are no lon…

> Many people (will only speak to America), view being fat as a literal moral failing. Gluttony or overeating are not the sin, but being fat. I feel like I've seen and heard more of the opposite: The trend is to avoiding anything that might make someone feel blame for arriving in their situation. With obesity the trend is to blame some combination of "our food supply", trending science topics like microplastics or th…

It's clearly both. Someone with stronger motivation to stay healthy can survive in adverse conditions, but a society that pushes unhealthy lifestyle harder is going to catch more people out. It's obvious that Americans aren't just all individually lazier than the rest of the world. Their cities and food are unhealthy.