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In the Asian Flu of 1957-58, they rejected lockdowns (2021)

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Re: In the Asian Flu of 1957-58, they rejected lockdowns (2021)

#291

Earlier quoted context omitted.

Briefly, as the substance is discussed in my other reply: > the big variation (e.g. R0 from 3.7–203.3 for measles, per my other comment here) is real Morpheus: "What is real? How do you define, real?" CIs that wide are just an obfuscated way of saying "we have no idea what's going on or what will happen". Anyone can make predictions that way. For example by the end my life my bank balance will be $4.7 million (CI $5.…

> You can define growth rate of a plant this way: define a standardized lab environment [...] If the standardized lab environment is dry and sunny, then you'll conclude that a cactus grows faster than a fern, since the ferns will mostly shrivel up and die. If the standardized lab environment is moist and shaded, then you'll conclude that the fern grows faster, since cactuses will mostly die for lack of sun. So which…

Neither can be said to be right without reference to a fixed context. If your field standardizes on a lab setup that's drier and sunnier than what ferns like, you'd indeed conclude that ferns grow slower in that context and that's OK because the growth rate is at least well defined. If there's a use case for comparable growth rates in different contexts, OK, define separate names for those rates and measure them separately. Or try to isolate the effect of heat and light such that the growth rate of any plant can be computed from the equivalent of e=mc^2.

Likewise you wouldn't try to measure the infectiousness of HIV in people, clearly. If you want to measure the relative "infectiousness" of viruses in humans using precise numbers then you'd need a controlled experimental environment, presumably something in vitro. That would miss a lot of factors that are important if you're trying to predict epidemics at the society-wide level, but OK, so be it. You need a firm footing of the basics before you can progress to more complex scenarios.

I don't really agree that it's unreasonable to expect CS-level rigor in biology. Microbiologists seem to manage it? It's expected that if two labs sequence the same organism they can in principle get the same DNA sequence, and if they do Xray crystallography on the same protein they'll derive the same structure. So we're not even comparing biology and CS here, we're comparing microbiology with epidemiology. The latter seems to be far closer to a social science in terms of its methods and rigor.

To be clear, it's also fine to do epidemiology using less rigorous methods if it was done in the way it mostly used to be done. When I read papers from the 80s they seemed to be much more appropriate to the actual data quality - largely prose oriented, very limited use of maths, presenting falsifiable hypotheses whilst admitting to the big unknowns. That's fine, science doesn't always have to be precisely quantifiable especially on the margins of what's known. But if scientists do precisely quantify things, then those quantities should be well defined.

Re: In the Asian Flu of 1957-58, they rejected lockdowns (2021)

#292

Earlier quoted context omitted.

Similar things happened in Québec. There was a curfew, unless you had to walk the dog. You couldn't buy certain products, but the stores were as much as crowded. If it was that deadly and every knew someone who died, they wouldn't go outside.

> If it was that deadly and every knew someone who died, they wouldn't go outside. It's not quite that simple. Some people might be forced to for work or similar. Which the law can provide protection against.

Specific class of people can be isolated. No need to put the population in de facto house arrest.

Re: In the Asian Flu of 1957-58, they rejected lockdowns (2021)

#293
post #274

Earlier quoted context omitted.

Observed excess US deaths: 1.34 million. Expected deaths from an unchecked epidemic: 330 million × 50% infection rate × 4% fatality rate = 6.6 million. 50% infection rate is the estimated no-lockdown epidemic penetration rate that I remember hearing from an epidemiologist. 4% was the fatality rate in Italy, February 2020, when hospitals were overwhelmed. Not even close.

4% in Italy isn't just "when hospitals were overwhelmed", it's with an aging population.

Did you actually look at the population pyramid for Italy, and compared it to the one for the US, before you made that argument? I don't think you did.

Besides, even if the true number was 3.8% or 4.3%, that wouldn't change the conclusion.

Re: In the Asian Flu of 1957-58, they rejected lockdowns (2021)

#294

Earlier quoted context omitted.

No replies with the downvotes, as impressive as usual. Looking back at this thread it seems every post disagreeing with the ridiculous statement that there were no lockdowns has been downvoted. Amazing.

I upvoted you because I agree with the essence of what you write. The problem is admittedly the enormous geographic variability of the measures that were adopted. None of us is quite sure if the debate is focusing on measures of Elbonia or rather those of Santa Banana.

Well then lets apply the same standard to the statement that there were no lockdowns. Some countries like New Zealand wouldn't even let their own citizens fly home, and there were stories about people in China having their doors nailed shut by the police. You don't get to make a blanket statement that, "there were no lockdowns" and then downvote everyone that replies because they weren't specific enough.

Re: In the Asian Flu of 1957-58, they rejected lockdowns (2021)

#295
post #282

Earlier quoted context omitted.

https://www.cdc.gov/mmwr/volumes/71/wr/mm7106e1.htm > Consistent use of a face mask or respirator in indoor public settings was associated with lower odds of a positive SARS-CoV-2 test result (adjusted odds ratio = 0.44). Use of respirators with higher filtration capacity was associated with the most protection, compared with no mask use. I'll take a reduced risk, even if it's not perfect. Would you prefer to get cov…

How did they account for people "doing something different" when wearing a mask? I.e. did they do a double-blind experiment where people wore masks that had intentional holes in them? So we can know that wearing a mask is the thing to do vs whatever it is that wearing a mask caused that person to do. I guess I'm asking or saying that this might have been some sort of "correlation is not causation" kind of thing?

I get that for whatever reason folks like yourself don't want to believe it, but trust me, masks work. Just ask anyone who works in asbestos abatement or BSL-2+ facilities.

Re: In the Asian Flu of 1957-58, they rejected lockdowns (2021)

#296
post #175

Earlier quoted context omitted.

Why does it matter? When crafting the policy response, what matters is how many people will actually die, not some theoretical obesity-adjusted cfr

I would agree, but we're talking about 35 to 40% prevalence of obesity and all the attendant diseases caused by it in the US. If the next wave of the flu or pneumonia would kill those same people who were pushed over the edge by COVID, would you be for lock downs and business closings in these cases too? Because that's what happens whenever a person with that many comorbidities gets an infection like the flu or pneum…

>Sadly, my nephew in his early twenties at the time received the vax and was rushed to the emergency room by ambulance with myocarditis, and to this day has follow-up appointments to track his cardiac health.

>Among 192 405 448 persons receiving a total of 354 100 845 mRNA-based COVID-19 vaccines during the study period, there were 1991 reports of myocarditis to VAERS and 1626 of these reports met the case definition of myocarditis.

https://jamanetwork.com/journals/jama/fullarticle/2788346

Myocarditis is one of very few side effects from the vaccine, all of which are vanishingly rare. It's well understood that the vaccine was highly effective in reducing the severity and spread of COVID and is one of the safest vaccines ever produced.

>How well it works: Moderna’s initial Phase 3 clinical data in December 2020 was similar to Pfizer-BioNTech’s—at that point, both vaccines showed about 95% efficacy for prevention of COVID-19. Later data on real-world effectiveness for adults showed that the protection from the mRNA two-dose primary series wanes over time, but booster doses bring the immune system back to robust levels.

https://www.yalemedicine.org/news/covid-19-vaccine-compariso...

You didn't ignore the mob, you ignored the science. You listened to a mob of your choosing, and now you are misinformed and continuing to spread misinformation.

Re: In the Asian Flu of 1957-58, they rejected lockdowns (2021)

#297

Earlier quoted context omitted.

[flagged]

> Simply saying "you're wrong" is not an argument. Right, which is why I followed up with a categorical and complete description of the problems with your nonsensical word salad. >> Please look up what habeas corpus means. > You cannot detain people without charges or probable cause. No, you're thinking of the Fourth Amendment. Habeas corpus is the mechanism by which a person can report a suspected unlawful detention…

> Right, which is why I followed up with a categorical and complete description of the problems with your nonsensical word salad.

Just because you disagree doesn't mean you have to be provocative and impolite. It's also against HN's rules BTW.

> Habeas corpus is the mechanism by which a person can report a suspected unlawful detention or imprisonment to a court,

You're making a distinction without making a difference. People were detained without charges or probable cause and were not allowed legal remedy.

> Obviously this has nothing at all to do with vaccines except in the fever swamps.

I was talking about lockdowns...

> Not therefore a right, got it.

Just repeating a statement won't make it true, it just makes you arrogant.

Informed consent directly derives from the right to bodily autonomy. It is such a basic right that if its blatant violation can be prosecuted regardless of jurisdiction. It is also protected by the 4h Amendment.

> What you're referring to as 'socialized' here is the government, which we as citizens and resident aliens agree to recognize in order to increase and defend the common good. For example, we agree to being policed, we agree to being taxed, we agree to being bound by laws, and we agree in particular in this case to working together to try to stop the collapse of healthcare systems, even if that is inimical to the political chances of the president at the time.

Actually "we" didn't "agree", what ever that means. The "common good" was never the foundation of the US, it was a Republic (thus power by and for the people) with limitations to protect individual liberties to limit the tyranny of the majority (the funding fathers were actually very critical of Athenian democracy BTW).

Taxes and police have their legitimacy through elected officials. But lockdowns and forced vaccination were put into place through edicts, the vast majority of whom were struck down by the Supreme Court, and thus never had the consent of the people nor respected individual rights.

Re: In the Asian Flu of 1957-58, they rejected lockdowns (2021)

#298

Earlier quoted context omitted.

I upvoted you because I agree with the essence of what you write. The problem is admittedly the enormous geographic variability of the measures that were adopted. None of us is quite sure if the debate is focusing on measures of Elbonia or rather those of Santa Banana.

Well then lets apply the same standard to the statement that there were no lockdowns. Some countries like New Zealand wouldn't even let their own citizens fly home, and there were stories about people in China having their doors nailed shut by the police. You don't get to make a blanket statement that, "there were no lockdowns" and then downvote everyone that replies because they weren't specific enough.

Yes, if the guy writing that is in one of those countries with lockdowns. But if he's in say Switzerland, he's not exactly wrong. Listen I'm not going to defend intellectually dishonest people either but I'd invite him to clarify which country.

Re: In the Asian Flu of 1957-58, they rejected lockdowns (2021)

#299

Earlier quoted context omitted.

> You can define growth rate of a plant this way: define a standardized lab environment [...] If the standardized lab environment is dry and sunny, then you'll conclude that a cactus grows faster than a fern, since the ferns will mostly shrivel up and die. If the standardized lab environment is moist and shaded, then you'll conclude that the fern grows faster, since cactuses will mostly die for lack of sun. So which…

Neither can be said to be right without reference to a fixed context. If your field standardizes on a lab setup that's drier and sunnier than what ferns like, you'd indeed conclude that ferns grow slower in that context and that's OK because the growth rate is at least well defined. If there's a use case for comparable growth rates in different contexts, OK, define separate names for those rates and measure them sepa…

> That would miss a lot of factors that are important if you're trying to predict epidemics at the society-wide level, but OK, so be it. You need a firm footing of the basics before you can progress to more complex scenarios.

That's how EE/CS stuff usually works (at least outside ML), building complex systems hierarchically out of well-understood primitives. The life sciences are different. There's almost nothing there we understand well enough to build like that, so almost all results of practical importance (a novel antibiotic, a vaccine, a cultivar of wheat, etc.) are produced by experiment and iteration on the complete system of interest, guided to some extent by our limited theoretical understanding.

This discrepancy has been noted many times; it's just a completely different way of working and thinking. If you haven't, then you might read "Can a biologist fix a radio?".

> Microbiologists seem to manage it?

A grad student in microbiology can grow millions of test organisms in a few days, at the cost of a few dollars, and get all the usual benefits of the central limit theorem. A grad student in epidemiology absolutely can't, since their test organisms are necessarily people. So you're quite correct that it's basically a social science, since it depends on aggregate human behavior in the same way e.g. that economics does, and is therefore just as dismal. Unfortunately it's also the best and only science capable of answering questions of significant practical importance, like whether the hospitals are about to be overrun. I'd tend to agree that stuff like Imperial College's CovidSim has so many parameters and so little ground truth as to have almost no predictive value. R0 seems fine to me though, and usefully well-defined, in the same way that the CAGR of a country's GDP seems fine.

In the life sciences, it's often possible to design an experiment under artificial conditions that will get a repeatable answer, like the growth rate of a plant in a certain controlled environment. It's much more difficult to use the result of such a repeatable experiment for any practical purpose; consider, for example, the steep falloff in drug candidates as they move from in vitro screens (cheap and repeatable, but only weakly predictive) to human trials (predictive by definition, but expensive and noisy). I'm absolutely not a life scientist myself, in part because I think I'd find that maddening; but essentially all results of practical benefit there came from researchers working in that way.

Re: In the Asian Flu of 1957-58, they rejected lockdowns (2021)

#300

Earlier quoted context omitted.

Yes, the word lockdown means forced quarantine of the entire population by law (except "essential" workers). Were they really voluntary everywhere in the USA? For example, the UK is still processing a giant backlog of fines and imprisonments for people who violated lockdown rules, more than 28,000 so far. You were allowed to go for a walk alone or with members of your household once per day, and go to supermarkets, b…

In the lefty commie California Bay Area where everyone "believes in the science", I was never, ever stopped by the lockdown police to ask why I was outside. I don't know why the UK issuing thousands of fines is relevant to this discussion.

Fair enough, then it's not relevant and I shouldn't have brought it up. I think a lot of people in the rest of the world don't realize how much less totalitarian the restrictions were in the US.
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