I am moving from a laptop as my at-home computer to a quiet-build mini-ITX system literally this week, after the last parts arrive from Newegg.
I think the ongoing market fragmentation resulting from the incompatible proprietary laptop form factors is pushing the whole industry towards consolidation and mergers, and will result in less consumer choice in the long run. I have been privately railing against this crap ever since Dell started shipping not-ATX-but-looks-like-it-at-first-glance power supplies in late 1990s. And Apple has always almost gratuitously used proprietary connectors and form factors, even when a perfectly usable standard already existed. They can all go to a Hell where nothing can interoperate without at least two adapters, and you never have both.
I was driven to the custom build when the headphone jack on my laptop broke. I opened up the case and desoldered the broken one, and the microphone jack, and resoldered the unbroken jack into the headphone jack's place. That worked for a while. Then the laptop keyboard stopped responding to about 5 keys--all of them rather indispensable for typing words. So I replaced the keyboard, and the replacement is just a millimeter too small, so it constantly pops out of its recess whenever it shifts and the plastic clips disengage. Then the headphone-jack-formerly-microphone-jack broke like its predecessor. I already knew the component itself was impossible to find to replace it, so I looked to replace the motherboard. That would cost more than a newer, more capable laptop, if the part had even been in stock.
So I'm building a system such that if anything breaks, I can just replace that one part. I can't get decent repairability without building it myself, and I can't build it myself if there aren't any rassafrassin' standards! I would have built my own clamshell computer (not even necessarily a "laptop"), but no one mass-produces an empty clamshell case for consumer sales, because there is no laptop-standard form factor. Replacement parts for laptops are always expensive, and frequently out of stock.