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Creatine raises brain energy levels and slows cognitive decline: study

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Re: Creatine raises brain energy levels and slows cognitive decline: study

#281

The article made up the claim it’s not from the paper itself. There was some improvement in cognitive scores, but no placebo group. Without a placebo group, there are a lot of explanations for the data.

Lots of creatine gummy dropshippers trying to gain ground.

Those gummies also usually have a fraction of the creatine they claim they do.

Re: Creatine raises brain energy levels and slows cognitive decline: study

#282

Earlier quoted context omitted.

I work out but I've never taken it. I feel like not everything has to be minmaxed, sometimes some things are better left to nature. Easy come easy go as they say

If you dont eat meat nature will not help you here. It will change your life if you're vegan.

I don't know much about creatine, how's that supposed to help change one's life ? Is it from your experience ? A quick search learned me it helps for physical activities of the explosive type.

edit: I saw your other comment, if you want to give more information that would be helpful, thanks. https://news.ycombinator.com/item?id=48346947#48347768

Re: Creatine raises brain energy levels and slows cognitive decline: study

#283
post #189

Feedback about creatine often seems mixed. Many love it, but many also report problems. Just in this thread there are people talking about heart palpitations and sleep problems. I have the theory that these side effects and mixed experiences come from impurities of lesser quality products. Apparently there are mostly two sources: Creatine mono-hydrate which mostly comes from China and "creapure", which is a patented…

> Creatine mono-hydrate which mostly comes from China and "creapure", which is a patented formula known for its purity. Creapure sells Creatine Monohydrate not a proprietary form of creatine [1]. The higher end in creatine is Creatine HCL which is more expensive but more water soliable, easier on the stomach, and requires a smaller dose. In terms of creatine manufactured in the Western World: * CON-CRĒT manufactures…

Weird, I’ve heard the HCL is harder on the stomach. I’ve actually never met anyone who uses monohydrate that reports any gastric issues whatsoever.

Re: Creatine raises brain energy levels and slows cognitive decline: study

#284
post #256
post #130

Earlier quoted context omitted.

Hei more than that - as an avid weed consumer - drugs are not dangerous by themselves especially when you don't like them - they are dangerous when you create space for them and get along with them. I like to believe weed is my little "cheat" - but i'd argue that any product is an abuse on a daily basis - so taking creatine once in a while might be fun to try out - but i would warn about anything on the spectrum of "…

You need creatine to live. Your body typically makes enough from protein to survive (vegetarians and vegans might need extra vigilance here). This is just taking more to optimize performance. It's not the same.

right...

https://www.google.com/search?q=artificial+creatine+side+eff...

kidney damage. liver damage. kidney stones. weight gain. bloating. dehydration. hair loss. muscle cramps.

The fact that you estimate weed as a drug is correct - the fact that you don't realize that everything is basically a drug depending on the amount an potency is worrying.

Re: Creatine raises brain energy levels and slows cognitive decline: study

#285
post #67

Earlier quoted context omitted.

Do you work out? If so creatine is supposed to help people push themselves harder and thus build more muscle. As a side-effect of intense exercises you'll create more testosterone. Increased testosterone leads to balding.

Sometimes when I see muscular guy with a head full of hair, I wonder what is counteracting that increased testosterone.

The comments here are unfortunately reddit-level of (in)correctness, but if you really want to know: testosterone doesn't affect your hair in any way, what does affect it is DHT which is synthesized from testosterone by your body with 5α-Reductase and the way to significantly dial down that process is to take 5α-Reductase inhibitors (widely available and affordable medications).

Re: Creatine raises brain energy levels and slows cognitive decline: study

#286

Curious if anyone has had hair issues while taking it. I’m aware that there’s no positive evidence for an effect, but there is an at least plausible mechanism. I’ve gone through two periods where I took it and liked the effects, but felt like I shed way more hair and stopped due to that.

There was one study that has never been replicated that showed it increased DHT levels in Rugby players. Higher DHT levels are associate with hair loss and enlarged prostate. Creatine has always come with too many side effects for me as well, I don't get how people take that stuff every day.

Re: Creatine raises brain energy levels and slows cognitive decline: study

#287
post #100

The first time I took creatine (6g IIRC), I actually felt the mental effect just 2 minutes later. A pleasurable sensation of augmented presence and (mental) relaxation. I paused taking that momentarily out of precaution while I wait some physical issue to normalize, but I plan to resume it in some weeks. Also it is considered a very safe supplement.

Did you inject or smoke it in order to feel "the mental effect just 2 minutes later"? Taken orally it can only be placebo effect.

Re: Creatine raises brain energy levels and slows cognitive decline: study

#288
post #284
post #256

Earlier quoted context omitted.

You need creatine to live. Your body typically makes enough from protein to survive (vegetarians and vegans might need extra vigilance here). This is just taking more to optimize performance. It's not the same.

right... https://www.google.com/search?q=artificial+creatine+side+eff... kidney damage. liver damage. kidney stones. weight gain. bloating. dehydration. hair loss. muscle cramps. The fact that you estimate weed as a drug is correct - the fact that you don't realize that everything is basically a drug depending on the amount an potency is worrying.

Water is bad for you if you drink too much.

Re: Creatine raises brain energy levels and slows cognitive decline: study

#289
post #88
post #58

Earlier quoted context omitted.

>> Recently, a pilot study (single-arm) by Smith et al., recruited 20 patients (73 years of age) with AD and provided them with 20 grams/day of CrM for 8 weeks [20]. Serum creatine levels were increased at weeks 4 and 8 (p Yeah 20 patients is not a lot. I'm inferring this is a pre-post test. However some of those p-values are pretty good (.001 on reading and and sorting). Very promising pilot study but not conclusive…

19 patients completed, according to the article. And List Sorting, Oral reading, and Flanker only? The first and last are part of global and fluid composites, so those have to be excluded from comparison. That leaves us with 3 improved scores out of 12 tests. So 9 did not improve, or got worse. Figure 3 (of the original article) shows that the changes aren't big. Just "significant". Since the participants were in the…

I can’t help but feel that the participants being in the early stage of dementia is a lede being buried. Perhaps I’m misunderstanding.

Re: Creatine raises brain energy levels and slows cognitive decline: study

#290
post #151

Earlier quoted context omitted.

I haven't seen any evidence an LLM is trainable to be a decent detector for anything people have made any kind of attempts at trying to get past them. Which is as expected as access to a detector effectively makes the problem equivalent to the halting problem (you can tweak the output using a detector as judge until you have a process to bypass it). Some of them are somewhat able to recognised "raw" output.

Yes, and the problem we are having here is 'raw' output. LLMgenerated slop is zero-effort bullshit, not an elaborate scheme to prove a philosophical thesis. There is no economy for mediaworkers doing the latter. Similar as with coding, yes, halting problem!, but we've been always reviewing code nonetheless.

When I'm talking about raw vs. something processed here, the only processing I'm talking about is a prompt or two to clean up the obvious artefacts.
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