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Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

nature.com

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Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#281

Post by xolox »

YeGoblynQueenne wrote: post #242
hackernewds wrote: post #224

Earlier quoted context omitted.

the importance of "set and setting" is almost universally known and easily verifiable. I've had terrible trips when stressed out and beautiful revelational ones when in the right frame of mind. shrooms are not as benign as alcohol. you're usually even less in control of your mental state, which can be both amazing and scary

I don't dispute the "set and setting" idea. I am asking why that makes a difference in the therapeutic or otherwise beneficial use of psilocybin and why it doesn't make any difference with other drugs like aspirin. To clarify, as far as I understand, "set and setting" matters when taking psilocybin to get high, but microdosing is taking psilocybin (or other similar drugs) to very deliberatly not get high. So what doe…

In the context of taking psychoactive mushrooms to get a proper trip, there are the concepts of a good trip, a bad trip, and steering your trip towards the former and away from the latter, based on your thought patterns and emotions (so actively pursuing the intent to have a good trip in your mind).

Now I've never microdosed mushrooms, but it's not hard for me to imagine that this same concept applies, of actively pursuing a good experience, which can steer that experience in a good direction. It will just be at a much smaller scale.

For myself I think of this phenomenon as a kind of self-fulfilling prophecy (not meant as a judgement about others) which helps me to keep in mind that I'm the one in control (assuming doses are not excessively high, I think others in this thread call those "heroic doses").

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#282

Post by Kalanos »

BossingAround wrote: post #278
Kalanos wrote: post #222

Earlier quoted context omitted.

Did you read the paper? "However, we observed a trend towards impaired performance in some cognitive tasks (i.e., attentional blink and Stroop)... future research should also explore the potential impact of microdosing on aspects of human physiology that could compromise its long-term safety." How hard is it to come off it?

The only thing you quoted is the tudy saying that: 1) Their dose got the participants a little high still (and thus impaired cognitive tasks) 2) Their study did not investigate long-term safety Why would you jump to the conclusion that it is hard to come off of it?

1) that's a prolonged effect, not just mid-high

2) exactly, the long term effects on a lifestyle are unknown

3) i'm asking, not jumping. personal experience and lack of long term studies

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#283

Post by kebman »

yarg wrote: post #271
kebman wrote: post #65

Earlier quoted context omitted.

Why do you want to change your condition with a thing, when the answer is inside you?

Because searching inside for the answer when my brain keeps popping up with "nice train tracks over there..." doesn't really work for me.

So many addicts in here... You guys need counselling not micro doses.

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#284

Post by nibbleshifter »

erokar wrote: post #186
nibbleshifter wrote: post #170

> microdosing > half a gram doses of cubes. I don't think the studies designers really thought this one through.

Agree, does seems high.

0.5g of dried cubes is more so a "museum dose". Not visibly impairing for me, but certainly can feel something.

0.3g is about the ceiling for a microdose of dried cubes, and even then, that's a touch high for most people.

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#286

Post by TaylorAlexander »

YeGoblynQueenne wrote: post #218
TaylorAlexander wrote: post #210

Earlier quoted context omitted.

The phrase is “set and setting” meaning that it is strongly advised to only take psychedelics when you have a good mindset and a good setting. The thing about psychedelics is that you will have powerful mental imagery during the trip, that’s just how they work. So what is on your mind that day will affect what you think about, and with the power of psychedelics I’m told it could get scary or bad if you’re in a partic…

Thanks for taking the time to explain, but if I understand correctly in the instances you relate, you were taking mushrooms specifically in order to get high, correct? Whereas the OP (root of the thread) is talking about microdosing, which is, if I understand it correctly, taking drugs in an attempt to not get high, but get other benefits? As to the "powerful feeling of connectedness with the universe", well, I've be…

I just want to say that “getting high” is a very crude way of describing a mushroom trip. I don’t really take them to have fun. It’s more serious than that. I take them because there are long term mental health benefits when taken with the right set and setting. (Research supports this claim.) When I had those thoughts about my parents dying, it was a subconscious fear of mine coming up from my mind, and it caused me to change my behavior to call and visit my parents more.

So I really don’t see it as “getting high”, and that’s why people call it a trip rather than getting high.

My point about the connectedness is that it’s not mysticism, that’s just how people really feel. Don’t misunderstand those descriptions as the person being more mystical than you. That’s how you’d feel on the right dose of mushrooms too.

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#287

Post by hnfong »

adrian_b wrote: post #213
jimmaswell wrote: post #172

Earlier quoted context omitted.

https://www.merriam-webster.com/dictionary/macro

That dictionary only records the fact that most English speakers now use the word "macro" incorrectly, which was my point, because they do not know Ancient Greek and they follow some previous English speakers who also did not know Ancient Greek, but that did not stop them to use a Greek word they thought as sounding fancy and whose meaning they attempted to guess, without bothering to look in a dictionary, so they ha…

The funny thing about prescriptivists is that they don't have a consistent story or makes arbitrary choices.

I don't know any Greek or non-English European languages, but assuming what you said is accurate:

> ("macro" is cognate with words from other European languages which mean slim/slender/thin/lean, only in Ancient Greek its meaning has shifted from "slim" to "long", replacing the older word for "long", "dolicho").

> most English speakers now use the word "macro" incorrectly, which was my point, because they do not know Ancient Greek

Given that the Ancient Greek meaning is not the "original" meaning anyway, is there a reason to assume that the Ancient Greek usage is "correct" and modern English is "wrong"? How long do we have to go back in time, given that most of us don't have time machines?

Also, why would you draw the line between using existing "wrongly constructed" words and creating them? Aren't using words part of the creation process? Why don't you create alternate versions of words that are more correct? Wouldn't you say that those who allegedly created "wrong" words have the same consideration as you do (i.e. if they used the "correct" way to construct new words nobody would understand them)?

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#288

Post by yarg »

kebman wrote: post #283
yarg wrote: post #271

Earlier quoted context omitted.

Because searching inside for the answer when my brain keeps popping up with "nice train tracks over there..." doesn't really work for me.

So many addicts in here... You guys need counselling not micro doses.

Addict? No - certainly not to mushrooms.

I have larger infrequent doses, and I'm doing so with decreasing regularity.

Although I guess you'd describe that as the binging form of addiction.

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#289

Post by hnfong »

effingwewt wrote: post #248
YeGoblynQueenne wrote: post #240

Earlier quoted context omitted.

Hi. Have I recently posted a comment that used offensive language like "pure bullshit" in response to one of your comments, or have I in some other way shown disrespect to you?

Quoted post unavailable.

The fact that they are quoting a children's fiction story that pokes fun at shamanistic cultures in response to a serious topic doesn't help their cause either.

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#290

Post by YeGoblynQueenne »

effingwewt wrote: post #248
YeGoblynQueenne wrote: post #240

Earlier quoted context omitted.

Hi. Have I recently posted a comment that used offensive language like "pure bullshit" in response to one of your comments, or have I in some other way shown disrespect to you?

Quoted post unavailable.

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