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Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

nature.com

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Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#271

Post by yarg »

kebman wrote: post #65
yarg wrote: post #3

(It's strange that we're using the term microdose, even in scientific contexts - prefixes have meanings - it should be called a decidose.) Anecdotally, I've had a degree of short term success treating my depression with smallish doses of mushrooms, but I've never had the continuing access required for a microdosing regiment. It'd be nice if the government were willing to come to the table on this, but alas. That said…

Why do you want to change your condition with a thing, when the answer is inside you?

Because searching inside for the answer when my brain keeps popping up with "nice train tracks over there..." doesn't really work for me.

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#272

Post by yarg »

jrochkind1 wrote: post #125
yarg wrote: post #3

(It's strange that we're using the term microdose, even in scientific contexts - prefixes have meanings - it should be called a decidose.) Anecdotally, I've had a degree of short term success treating my depression with smallish doses of mushrooms, but I've never had the continuing access required for a microdosing regiment. It'd be nice if the government were willing to come to the table on this, but alas. That said…

> It'd be nice if the government were willing to come to the table on this, but alas. They're starting to, although they haven't funded a study on microdosing for depression. > [October 2021] Johns Hopkins Medicine was awarded a grant from the National Institutes of Health (NIH) to explore the potential impacts of psilocybin on tobacco addiction. This is the first NIH grant awarded in over a half century to directly…

Different country, even more useless government.

Though the progress in the US/Canada makes me think that maybe in 15-20 years NZ can have a referendum and continue with prohibition.

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#273

Post by selimthegrim »

YeGoblynQueenne wrote: post #234
hackernewds wrote: post #221

Earlier quoted context omitted.

Bit of a tangent here but I noticed you used "her" instead of the default assumption of "him". Is this a new practice?

I think that's because the OP's handle is "EmilyHughes". Is "Emily" a name that's common for males? I know some English names can go both ways like Evelyn or Shannon etc, but is Emily one of them?

Emil or Emlyn (Latin and Welsh) are similar male versions.

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#274

Post by Enginerrrd »

jerojero wrote: post #174
Enginerrrd wrote: post #127

Earlier quoted context omitted.

>This, to me. means that a microdose is a gamble not worth taking. This has always been the problem with psychedelics as a therapeutic approach. It's hard to reconcile being a responsible clinician and recommending a therapy with such mixed and often-negative results. They are in charge of a person's mental well-being in a way that people evangelizing psychedelic therapy don't seem to properly appreciate. If a patien…

As far as I know experiments of CBT + psychedelics have shown very promising results for treating PTSD and certain kinds of depression, specially in people that are about to die and need to come to terms with that. These are not microdosing experiments though. The usual way it is handled is that you get a few weeks of CBT then you get half a dose and the following week you get a full dose followed by more weeks of CB…

Just because you know for sure you got the drug DOES NOT mean "no placebo effect is possible" (!)

That just means you can't possibly have a proper control. BIG difference.

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#275

Post by phist_mcgee »

___2-__---_--__ wrote: post #138

Thanks for all the great info. EROWID was long before the decriminalization trend, the "right thing" to check before you trip\try any new subtance people might use for psychoactive effects. And many (including "heroic-to-crazy" sounding combinations) pharm-and-farm\forrest caffeine+substanceX etc. Look for "trip reports" section, if its still in business. And any geek who had The Way Things Work on the (rents'?) book…

You might want to lay off the psychoactives a bit..

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#276

Post by EmilyHughes »

Scalestein wrote: post #194
EmilyHughes wrote: post #20

Been doing it for some months on & off, this shit is legit. Altough 0,5g has me tripping so I rarely dose above 100 milligrams. Get up early, do a workout, take cold shower, meditate and then pop a microdose shrooms, feels great. Microdosing is like steroids for meditation. Especially helpful for the programmer logic types of people like me, gets you out of your head for some time and helps you connect with your emot…

Does your daily routine change when you microdose? Do you still take the cold shower and meditate and all that regardless of it being a microdose day or not? I found that when I was microdosing it made me way more mindful and apt to make "good/healthy" choices than normal. I think this is a tremendous benefit but for me very difficult to differentiate from a placebo effect.

No it doesn't - that's my daily routine. I just microdose on some days on top of it.

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#277

Post by BossingAround »

loeg wrote: post #185
BossingAround wrote: post #86

Earlier quoted context omitted.

As a daily Kratom user, I would not recommend using Kratom for something like depression. You're treating the symptomps at best while cultivating addiction.

Why daily?

Chronic pains. I try to skip days when my pain is better, but those are not very frequent.

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#278

Post by BossingAround »

Kalanos wrote: post #222
BossingAround wrote: post #94

Earlier quoted context omitted.

> but a bad lifestyle choice Care to elaborate why?

Did you read the paper? "However, we observed a trend towards impaired performance in some cognitive tasks (i.e., attentional blink and Stroop)... future research should also explore the potential impact of microdosing on aspects of human physiology that could compromise its long-term safety." How hard is it to come off it?

The only thing you quoted is the tudy saying that:

1) Their dose got the participants a little high still (and thus impaired cognitive tasks)

2) Their study did not investigate long-term safety

Why would you jump to the conclusion that it is hard to come off of it?

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#279

Post by SergeAx »

Skimming the abstract, my eye catched a mention of the "Lempel-Ziv". I know it's a name of algorithm used in early loseless file archivers (later replaced by Lempel-Ziv-Welch, which is used today in GIF image compression). Imagine my surprise learning that part of this algo is used now in biomedicine to measure complexity of brain activity. Truly, one never knows where things are gonna end up.

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#280

Post by hiram112 »

j_m_b wrote: post #122

I'm sort of surprised they didn't extract/synthesize psilocybin directly and administer that. Decades ago, I grew a few batches of P. Cubensis. Even amongst mushrooms from the same rice cake, the dosage wildly varies. You could have a "trip" from a tiny mushroom or eat a handful of duds.

Apparently, one of the companies actively pursing psilocybin for medicinal purposes has just patented one of the main methods of synthesis. From what I remember from the article that hit HN just last week regarding one of the main chemists for this company, this may be putting off researchers and others from using anything other than the natural mushrooms in their trials, tests, products, etc.

* https://www.vice.com/en/article/93a5x3/judges-deny-challenge...

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