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Psilocybin 'promising' for depression

bbc.co.uk

281–290 of 324 posts

Re: Psilocybin 'promising' for depression

#281

Earlier quoted context omitted.

who what why when where how ever notice how all these stories lack that? all? look, don’t respond to why that might be, but lets just all push for the study and a legal framework that allows for said studies to exist

Here's a summary with links to studies. https://en.m.wikipedia.org/wiki/Substance-induced_psychosis

> F16.5 hallucinogens (LSD and others)[citation needed]

no studies found.

Re: Psilocybin 'promising' for depression

#282

Earlier quoted context omitted.

> There are molecule combinations out there which can cause instant parkinson’s disease Is this real or exaggeration for effect? It sounds implausible...

With 3 days of use. Parkisons disease in 20 years old. Simulatable in primates and mice by giving them this drug. https://en.m.wikipedia.org/wiki/MPTP https://www.cdc.gov/mmwr/preview/mmwrhtml/00000360.htm Be careful out there, test your drugs.

(*Within 3 days after use)

Re: Psilocybin 'promising' for depression

#283

Earlier quoted context omitted.

It temporarily breaks you out of your established mental framework. It's as if your raw consciousness viewing the world without any of the filters that we all use to tune out the noise. That's why the experience can be overwhelming and chaotic and it's useful to be in a safe place with a trip sitter. I think the magic comes when you discover that something your default mindset was filtering out as noise is actually s…

>I think the magic comes when you discover that something your default mindset was filtering out as noise is actually signal. With that insight, you can more easily make changes to your sober mindset. Regarding microdosing (as described by the OP) this begs the question: Are there perhaps unwanted side effects for running your brain on permanent "debug mode"?

Hard to say. This is the first study I've seen that's tried to learn about microdosing. There's not a lot of good data on it, but it wouldn't be hard for me to believe that there are some side effects.

Re: Psilocybin 'promising' for depression

#284

Earlier quoted context omitted.

It temporarily breaks you out of your established mental framework. It's as if your raw consciousness viewing the world without any of the filters that we all use to tune out the noise. That's why the experience can be overwhelming and chaotic and it's useful to be in a safe place with a trip sitter. I think the magic comes when you discover that something your default mindset was filtering out as noise is actually s…

That is interesting. So it is a bit like reducing your attention, and expanding awareness? What you described sounds very similar to the effects of mindfulness meditation. The idea in a sense is to increase awareness - that is, sensing the world as is, without the filters or influence of mental objects. The theory is that meditation can then help you free yourself of past negative conditioning that is no longer relev…

Definitely. Sam Harris' book Waking Up is what turned me on to psychedelics as a mind expanding tool rather than just a party drug, which I had little interest in.

In it, he talks about how his early experiences with psychedelics turned him on to the fact there was something real worth pursuing in meditation and mindfulness beyond the superstitious bullshit. Most of the book is about using meditation as a tool for spirituality without religious baggage or supernatural explanations.

The way he and others talk about it, is that psychedelics effectively force any mind into an objectively different state of consciousness. Even though it doesn't last long and the memory of it fades, just the awareness that radical mind shifts are possible is enough to help people take mindfulness practice seriously.

Re: Psilocybin 'promising' for depression

#286

I have a friend who has experienced magic mushrooms recreationally about half a dozen times in her 20s. After each trip she reported feeling clear headed and more mindful - she described it as though her mind's harddrive had been defragmented. Fast forward 10 years and that same friend felt low during lockdown over the past 12 months. After reading up online she decided to try microdosing mushrooms rather than the ma…

How much mushroom matter is considered a microdose? Or, how is it best measured?

One way to approach is that a microdose for you is any dose that has no notable psychoactive effect.

Practically, microdosing is often in the 20 - 100 mg range, and the lower threshold of a 'normal' psychoactive dose would be 600 - 800 mg (depending on the individual, eg. their weight, of course).

Re: Psilocybin 'promising' for depression

#287

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> Cocaine, Heroin, Meth, and Fentanyl should never be legal. They are too addicting. Maybe for you, but why should you be the arbiter of what other people do? Make it legal and tax substances to the point that the revenue offsets the potential negatives.

Because those people don't live in a vacuum. I know I'm just one case, but as someone who's mother got addicted to legally prescribed Fentanyl as well as other opioids as a result of her cancer treatments, and to had serve as caregiver for said mother when said drugs sent her into irrational rages and occasionally made her suicidal (she later admitted to not remembering multiple months of time from the years she was…

> Same reason even in the US while I can own an AR-15, I cannot own a Patriot Missile Battery

Au Contraire! Explosives are just very difficult to buy because you must go through an approval process to purchase a "destructive device" and the storage regulations, which vary widely from area to area, are (rightfully) difficult and expensive to comply with.

Re: Psilocybin 'promising' for depression

#288
post #274

I see articles about curing depression from time to time and I have hope but not much. I have lived most of my life as a depressed kid. The most jolting realization that I had as an adult was that around sixth grade I was contemplating suicide without knowing what that word meant. Since then, life has been like a long, slow death march. If you asked most of my friends they'd likely tell you that I'm really happy, fun…

As someone who also struggled with depression from an early age, taking mushrooms cured it.

I haven't taken them in over a decade and I did get in a funk during the pandemic, but the difference between the day before taking mushrooms and the days after are like night and day.

I would bet money that it would help you. If you decide to try them out, all you need is 3.5 grams and someone experienced to take them with you or at least sit with you. Oh, and put on some Shpongle.

Re: Psilocybin 'promising' for depression

#289

Earlier quoted context omitted.

Here's a summary with links to studies. https://en.m.wikipedia.org/wiki/Substance-induced_psychosis

> F16.5 hallucinogens (LSD and others)[citation needed] no studies found.

I'm not sure what this is responding to. The prior comments were asking about details around potential permanent psychiatric issues. There's some stuff in here about psychosis turning into schizophrenia, etc. It's rare, but we also can't dismiss it.

Re: Psilocybin 'promising' for depression

#290
post #142

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> decriminalisation no only recreational legalization would do that

Here in NL, large festivals have drug testing booths, where the visitors can have their drugs tested so they know what they'll be ingesting. That's possible because of decriminalisation and destigmatization. Legalization would allow the government to create a testing infrastructure so drugs can be tested/validated before they're sold, that's arguably better. But it's definitely possible to create a safer drug environ…

Drug testing is possible here in the US with overt criminalization.

Decriminalization is just marginally safer. Testing is a huge waste of resources unless its a stopgap towards recreational legalization with a reliable supply chain.

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