> As long as Linux lacks native support for Autodesk, Adobe CC, Office 365, FL Studio, Pro Tools, etc. and dozens of other niche programs by ISVs it will never approach the mainstream with any sort of widespread appeal.
Meh, I think it's not an all or nothing situation. My client uses exclusively Windows on the desktop but basically the most "advanced" applications they use are Excel and Outlook. Practically all their line of business software is web-based. Most run on Windows for some reason, but as far as the user is concerned, it's just a web app.
I bet that the situation is similar for most companies, and the other tools you mentioned aren't all that widespread. Of course, for the companies that use them to make money they're important. But I would say that's "specialized use" territory. I bet most of the people working for my client (> 3000 employees) have no idea what Pro Tools are, and they are more or less in the media sector.
I personally use the Adobe CC photography suite as a hobby. And although for the moment only lightroom is concerned, I get the feeling that adobe is looking to move the products to the cloud. Microsoft has already done this with Office 365.
For my (admittedly limited) use case, installed Office is dead. It's a pain to install, takes forever to update, and most importantly, works way, way worse than the online version. Outlook online doesn't lag and the messages scroll while I move the slider instead of waiting for me to let it go. Just like it used to before they switch to the new interface around 2013 or 2016 with all the white space. The online version even works on Firefox on Linux. Teams works on Linux too. Remoting to windows servers is way more practical on Linux (Remmina) than windows. So I would say that for my client, the reason they still use windows is basically inertia. I'm using Linux full time and never had an issue interfacing with the other people working there.