What kind of dose are the individuals being given? It says 2 high-level doses over a 6 week period. Are we thinking the antidepressant effects aren't from the trip itself, but from the aftereffects? That's sort of what's being discovered w/r/t ketamine therapy for depression.
Psilocybin 'promising' for depression
261–270 of 324 posts
Re: Psilocybin 'promising' for depression
#262I have a friend who has experienced magic mushrooms recreationally about half a dozen times in her 20s. After each trip she reported feeling clear headed and more mindful - she described it as though her mind's harddrive had been defragmented. Fast forward 10 years and that same friend felt low during lockdown over the past 12 months. After reading up online she decided to try microdosing mushrooms rather than the ma…
How much mushroom matter is considered a microdose? Or, how is it best measured?
Re: Psilocybin 'promising' for depression
#263I have a friend who has experienced magic mushrooms recreationally about half a dozen times in her 20s. After each trip she reported feeling clear headed and more mindful - she described it as though her mind's harddrive had been defragmented. Fast forward 10 years and that same friend felt low during lockdown over the past 12 months. After reading up online she decided to try microdosing mushrooms rather than the ma…
This is my experience too. I’ve been microdosing about 1.3mg on and off during lockdown. The effects are subtle and hard to describe but I’d say it’s like ‘opening your mind’ or reframing your point of view on things. Definitely different from other drugs which just pump you with serotonin
How do you measure this amount? If mushrooms vary in shape and size...do you have to ground them up and take gelcaps to measure this appropriately?
Re: Psilocybin 'promising' for depression
#264I was not able to speak to my father, let alone staying in the same room were he was, for about 26 years (~18yr old till recently ~44yr). The background for this was my choice of leaving an ultra orthodox jewish community and going on my own. I recently tried that (after 3 years of hesitation) and the magic happened. It affected my structure of feelings in several ways indeed, but in the context of this one, I would…
I think people should be generally afraid of any substance that can I give long term personality changes with just a few doses, sometimes even with a doctor's help.
I think people should be generally excited by the prospect of resolving long term psychological issues with just a few doses.
Re: Psilocybin 'promising' for depression
#265Earlier quoted context omitted.
Cocaine, Heroin, Meth, and Fentanyl should never be legal. They are too addicting. Possession in a small amount should be decriminalized using a stick (drunk tank for a couple days) or carrot (state run rehab or classes) method. Stop the prosecutions and jailing of the users. Mandate a class or whatever like they do for DUIs and provide a state run place to ween them off. Combined with a safe place to do drugs and sa…
I mean marijuana is more addicting to me than cocaine so....
Yes but no one is doing crackhead or dopehead things when they want Marijuana.
Re: Psilocybin 'promising' for depression
#266Earlier quoted context omitted.
Even with cannabis, states have no FDA that is prepared to do studies and I just wish a basic level of known side effects were listed from the actual FDA which they do for studied and much more harmful drugs, because they were studied When you add all the other scheduled drugs that have no state level recreational framework, then you no studies and you also have a compounded supply chain problem where nobody knows wh…
> There are molecule combinations out there which can cause instant parkinson’s disease Is this real or exaggeration for effect? It sounds implausible...
With 3 days of use. Parkisons disease in 20 years old.
Simulatable in primates and mice by giving them this drug.
https://en.m.wikipedia.org/wiki/MPTP
https://www.cdc.gov/mmwr/preview/mmwrhtml/00000360.htm
Be careful out there, test your drugs.
Re: Psilocybin 'promising' for depression
#267Earlier quoted context omitted.
Cocaine, Heroin, Meth, and Fentanyl should never be legal. They are too addicting. Possession in a small amount should be decriminalized using a stick (drunk tank for a couple days) or carrot (state run rehab or classes) method. Stop the prosecutions and jailing of the users. Mandate a class or whatever like they do for DUIs and provide a state run place to ween them off. Combined with a safe place to do drugs and sa…
>Cocaine, Heroin, Meth, and Fentanyl should never be legal. They are too addicting. I know 10X as many people who threw away their lives working minimum wage and minimum responsibility jobs just so that they can afford enough marijuana to make themselves happy with living without ambition. Not that I think marijuana should be illegal but if we are going to legalize one we should be consistent and legalize everything.
If they're happy with the lives they live, then how are their lives wasted? Is it possible they just have different values?
Re: Psilocybin 'promising' for depression
#268Earlier quoted context omitted.
I think people should be generally afraid of any substance that can I give long term personality changes with just a few doses, sometimes even with a doctor's help.
I see this argument a lot, and I think it is more hollow than it appears. I am certainly not the same person now that I was 10 years ago. Indeed, I am different than the person I was 1 year ago. Life happens, people change. Directing this change with psilocybin seems like a reasonable choice. Sometimes it may misfire, and you will be a bit worse off; but sometimes humans get depressed, angry, or otherwise negative fo…
>Life happens, people change. Directing this change with psilocybin seems like a reasonable choice. Sometimes it may misfire, and you will be a bit worse off; but sometimes humans get depressed, angry, or otherwise negative for lots of other reasons.
I think your rebuttal is more hollow than it appears. It ultimately ascribes equal value to all change, and all change no matter how poorly controlled.
Re: Psilocybin 'promising' for depression
#269Earlier quoted context omitted.
I think people should be generally afraid of any substance that can I give long term personality changes with just a few doses, sometimes even with a doctor's help.
I think people should be generally excited by the prospect of resolving long term psychological issues with just a few doses.
I agree, for people with long term physiological/psychological issues this might be a huge boon, and may be a better alternative than common anti depressants.
But I know many people who have done psylocybin for fun who are probably changed because of it, in an uncontrolled fashion.
Re: Psilocybin 'promising' for depression
#270Earlier quoted context omitted.
Just a personal note, I experienced the complete opposite. I knew I wanted to do great things and accomplish things of importance, but depression was like a black cloud holding me back from doing so. Psychedelics took away that cloud and also infused a deep level of meaning into my everyday life. I went from depressed and basically dropping off the edge of the world to traveling across the world and starting a startu…
Fwiw 4-HO-DMT is psilocin (it and psilocybin are both in mushrooms in varying amounts; and psilocybin metabolizes into it in the body). It probably wasn't legal. 4-AcO-DMT is a bit more of a grey area (probably covered by the analogues act; allegedly also metabolizes to psilocin in the body too).
You're very right, that was a late-night bleary-eyed mistake. 4-HO-MET (thanks to TiHKAL) is what I meant to type.