Earlier quoted context omitted.
Hi. Have I recently posted a comment that used offensive language like "pure bullshit" in response to one of your comments, or have I in some other way shown disrespect to you?
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Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study
251–260 of 303 posts
Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study
#252> microdosing > half a gram doses of cubes. I don't think the studies designers really thought this one through.
Agree, does seems high.
If you think the dose is too high, yet they found no significant effect compared to placebo, what would you expect would happen at a _lower_ dose?
Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study
#253Earlier quoted context omitted.
This study doesn't bear that out, nor have any other placebo-controlled trials. Also, I've experienced about 40 different psychoactive drugs, including both micro and megadoses of psychedelics. And my experience tracks with GP in that it does cognitively impair you. Maybe don't make blanket statements about people you disagree with, it doesn't make your argument look any stronger.
Erm, define "impairment". Yes this study notes reduced performance in some areas (but the authors acknowledge plenty of weaknesses and explanations in their discussion). However, increases in something like "creativity" might reduce e.g. verbal fluency, while increasing "performance" for artists, or increasing insights when problem solving in many disciplines.
Well, to look for impairment at any specific task, you want to just do that task, of course.
I agree there's really no meaningful concept of "general impairment" unless you're talking about something more extreme like a brain disorder or heavy alcohol intoxication with global involvement leading to something like a coma or gross movement disorder.
These various neuropsych tests try to test something as specific as possible. Working memory for instance. Their development is a complicated field all on its own. And this is psychology, so it's good to keep the reproducibility crisis in mind and adjust one's credences accordingly.
There's a really cool painter whose name I forget who mainly does self portraits while under the effect of various substances. The one where he huffed computer duster for instance,is just a few meaningless lines on a mostly white canvas. That's a pretty good example of global impairment right there. And there's also sorts of paintings on psychedelics, showing varying degrees of visual impairment. Really recommend googling the guy if you want a very visceral way of visualising the various impairments brought on by psychoactive drugs.
This is becoming an unfocused rant so I'll cap it off here I guess.
Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study
#254Earlier quoted context omitted.
I don't see how this may be relevant to the usefulness of microdosing. - Assume that a microdose either improves an outcome, or does nothing. Then, averaged over a large group, such random improvements would lift the group's outcome a little. It's a microdose worth taking. - Assume that a microdose can both improve and worsen the outcome, or have no effect. If the experimental group's averaged results are indistingui…
If the natural variability is high enough, then any effect will be hidden by it. Sure, we can say with some certainty that the effect of microdosing on most scales are not that huge. But we wouldn't have expected very large effect sizes anyway, because they are almost unheard off. (Unless the subjects become really severely impaired) And there may still be meaningful treatment effects, at least judging by current sta…
If the observed effect of an intervention does not rise above the background variance it means that the intervention does not do what you want it to do.
Either (1) it has no effect or (2) the strength and direction of the effect are random. Either of those qualities renders the intervention ineffective. You can’t justify giving a patient something that will have no effect, or will make them worse off half of the time when there are more effective options are on the table.
Of course this is comes with the caveat that the study is adequately powered to detect the strength of the effect you are looking for. That being said, there is plenty historical data for the placebo, so I don’t think that being underpowered because of misestimation of the background variance would be an issue.
Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study
#255Earlier quoted context omitted.
This study doesn't bear that out, nor have any other placebo-controlled trials. Also, I've experienced about 40 different psychoactive drugs, including both micro and megadoses of psychedelics. And my experience tracks with GP in that it does cognitively impair you. Maybe don't make blanket statements about people you disagree with, it doesn't make your argument look any stronger.
Now we have two blanket statements.
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Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study
#256Earlier quoted context omitted.
The dictionary records what word means, today, in the english language.
Like everybody else, I also have to use the words with their current meaning, so I use frequently words like "macroinstruction", possibly abbreviated to "macro", or "macroprocessor". That does not mean that one should not be aware that the creation of such words was based on laziness and ignorance and one should not coin any new words of this series.
> That does not mean that one should not be aware that the creation of such words was based on laziness and ignorance and one should not coin any new words of this series.
You say this, and yet you are writing English and not Proto-Indo-European. Curious!
Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study
#257Looks like they found no change on a wide variety of tests, like measurements of openness and creativity, except for an array of subjective, psychedelic experience questions like "Sounds influences things I see", "I see distorted shapes", etc.
Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study
#258Been doing it for some months on & off, this shit is legit. Altough 0,5g has me tripping so I rarely dose above 100 milligrams. Get up early, do a workout, take cold shower, meditate and then pop a microdose shrooms, feels great. Microdosing is like steroids for meditation. Especially helpful for the programmer logic types of people like me, gets you out of your head for some time and helps you connect with your emot…
Eh, just sounds like you have a good routine going, based on the study results you could probably skip the microdosing and achieve the same performance.
Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study
#259Participants were required to bring their own psilocybin mushrooms. Probably because it can be expensive and difficult for researchers to get obtain and administer pharma-grade psilocybin.
The dose was 0.5g of dried Cubensis mushrooms. Usually a microdose is 0.1-0.2g.
All the participants were healthy volunteers. There may be more noticable effects in people with depression or anxiety disorders, etc. Consider that antidepressants often have no effect in healthy volunteers.
Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study
#260Earlier quoted context omitted.
Assumedly, they nearly walked in front of a bus after microdosing(?) shrooms. If not, ELABORATE PLEASE.
yes, this. my awareness was somewhat diminished. but then again I had no proper way to really accurately microdose - so I might have taken too much. trying to accurately dose a natural product like mushrooms is rather difficult.
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