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Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

nature.com

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Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#81

Post by jmartrican »

hackerlight wrote: post #63
yarg wrote: post #3

(It's strange that we're using the term microdose, even in scientific contexts - prefixes have meanings - it should be called a decidose.) Anecdotally, I've had a degree of short term success treating my depression with smallish doses of mushrooms, but I've never had the continuing access required for a microdosing regiment. It'd be nice if the government were willing to come to the table on this, but alas. That said…

> night of turmoil. Can you elaborate?

My guess is OP is referring to a bad (or powerful) trip.

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#82

Post by BossingAround »

umvi wrote: post #77

Do mushrooms make you write incoherent ramblings on Facebook about how you are God and how everyone else is stuck in the matrix? Because I have 3 different friends who all started doing that after dabbling in psychedelics

The perceived effects of psychedelics can be very strong. That is why it's recommended to take them with a professional, so as not to become delusional, e.g. being a god.

However, the effects of even a single trip can be quite profound and life changing.

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#83

Post by EmilyHughes »

YeGoblynQueenne wrote: post #75
henriquemaia wrote: post #32

Earlier quoted context omitted.

That's an uncharitable reading. OP is just sharing what works with her/him. Which is ok. From what I understood from your comment, for you it doesn't. Which is ok too, as now you know yourself a bit better. Two personal experiments with very different outcomes. There's no need for moral judgments either way.

Does "if it works for you" also go for things like aspirin, antihistamines, antihypertensives, antibiotics, etc? I've never heard anyone say "if aspirin works for you then take it, but it doesn't work for me". I've only heard this kind of thing said for things like homeopathy, astrology, accupuncture, osteopathy, and microdosing, of course. Hence, I'm very skeptical. [Edit: OK, I've heard people say that aspirin does…

psychoactive drugs are a whole different category. You bring your whole mental baggage with you when you take them, unlike aspirin.

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#84

Post by jnovek »

umvi wrote: post #77

Do mushrooms make you write incoherent ramblings on Facebook about how you are God and how everyone else is stuck in the matrix? Because I have 3 different friends who all started doing that after dabbling in psychedelics

I’ve seen the observation that psychedelics evoke a sense of spirituality in people. I wonder if this is how people cope with that feeling of spirituality if they don’t participate in any organized religion?

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#85

Post by Thiez »

EmilyHughes wrote: post #47
dtx1 wrote: post #36

Earlier quoted context omitted.

Can confirm, especially mushrooms. I had one trip on them and what my main take away was: It's exhausting to trip on mushrooms and after 4-5 hours I wanted to be sober again. I'll probably do it again in a few month but for me it's a whole-weekend kind of deal and hardly a party drug

It can be a "party drug" if you dose low, especially if you are chilling at a bar with friends. Just pushes you into a slightly better mood. I'll rather have a microdose with some beers than getting shitfaced drunk, feels subjectively healthier to me.

Of course you could also just stop drinking after a few beers without taking additional drugs.

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#86

Post by BossingAround »

mritchie712 wrote: post #50
yarg wrote: post #3

(It's strange that we're using the term microdose, even in scientific contexts - prefixes have meanings - it should be called a decidose.) Anecdotally, I've had a degree of short term success treating my depression with smallish doses of mushrooms, but I've never had the continuing access required for a microdosing regiment. It'd be nice if the government were willing to come to the table on this, but alas. That said…

Have you tried Kratom? I'm by no means recommending it, just curious if you've tried it to combat depression.

As a daily Kratom user, I would not recommend using Kratom for something like depression. You're treating the symptomps at best while cultivating addiction.

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#87

Post by kybernetyk »

jstummbillig wrote: post #70
toxicFork wrote: post #68

Earlier quoted context omitted.

Can you elaborate please?

Assumedly, they nearly walked in front of a bus after microdosing(?) shrooms. If not, ELABORATE PLEASE.

yes, this. my awareness was somewhat diminished. but then again I had no proper way to really accurately microdose - so I might have taken too much. trying to accurately dose a natural product like mushrooms is rather difficult.

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#88

Post by kayza »

umvi wrote: post #77

Do mushrooms make you write incoherent ramblings on Facebook about how you are God and how everyone else is stuck in the matrix? Because I have 3 different friends who all started doing that after dabbling in psychedelics

It actually really does show you a „different reality“. It has different effects on different people, I assume. For me, it was quite eye-opening, in that it made me stop using cigarettes for example. But for others, it leads to those strange thoughts of living in the matrix or something

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#89

Post by BossingAround »

Gatsky wrote: post #31

I think this is saying that microdosing is mainly placebo effect, and otherwise doesn’t do much. This makes sense. All these participants took full dose psychedelics at some point, and thus had very strong associations.

So far, as far as I know, that seems to be the prevailing scientific opinion, i.e. microdosing seems to be about as effective as placebo (at least microdosing of psilocybin).

Re: Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

#90

Post by zosima »

In studies such as these with huge intersubject variability, and probably also quite large intrasubject variability from day to day on many scales, it makes sense to look at change from baseline for individuals in the various groups rather than just differences in raw scores between treatment groups.

It seems by a cursory glance that most analyses done were of the latter kind, and I think then a study such as this, with low N, is expected to not show very much effect of any kind. (Since the intersubject variability and potentially also the natural intrasubject variability for most measured scales seem higher than any expected treatment effect).

I am almost certain that e.g. none of the approved and quite convincingly working SSRI:s would have shown any efficacy in a study with this design and similar N.

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