Earlier quoted context omitted.
I don't know for sure, but these Radeon GPUs are power hungry and hot. It could be just that after multiple days the entire computer is heat soaked and goes through more thermal throttling than even the "steady state" GPU tests that most gamers do (a few hours). It might also be cruft building up over time with small memory leaks or imperfect memory management.
This is what I thought too, the heat simply becomes overwhelming and the unit has to underclock to prevent melting.
It's more likely the explanation above of something (not heat) accumulating over time and slowing down the processing.