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What Ozempic does to the gut-brain axis

psychologytoday.com

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Re: What Ozempic does to the gut-brain axis

#241

Post by mynameisash »

SoftTalker wrote: post #222
mynameisash wrote: post #209

Earlier quoted context omitted.

What breaks the hunger response, and how does one fix it? Maybe it's well-known, but I read the starvation response Wikipedia page[0] and didn't grok it. [0] https://en.wikipedia.org/wiki/Starvation_response

Buy unprocessed food and prepare it yourself. Don't add sugar. Eating processed food and even most restaurant food is eating food that's designed to make you want more, not satiate you.

I guess I should have asked about the technical mechanism of what causes and what actually 'breaks', and then what the technical remedy is.

Re: What Ozempic does to the gut-brain axis

#242

Post by faangguyindia »

phil21 wrote: post #219
faangguyindia wrote: post #176

Earlier quoted context omitted.

I have no personal animosity toward you, but I've heard all this many times, so I'll respond accordingly. >I've been on a diet since I was 12 years old, and am now approaching 50. I've lost and regained the same 60lbs about 4 times now You can lose weight by crash dieting, which does not prove much. The first thing that comes to mind for people is simply: "I'll just eat very little and lose weight." It even works, bu…

> In my experience, while people know all these things, execution still requires knowing all the "gotchas". In my experience, people that think they know all the "gotchas" don't really know as much as they think they do. Knowing fat is calorie dense is great. Without context one would attempt to try to cut it out of your diet almost entirely. Sort of like what literally happened with the food industry in the 80's/90'…

If you are taking shots at me, just know i wrote this guide:

https://www.reddit.com/r/tirzepatidecompound/comments/1omfgx...

which is often shared on fitness subreddits, nowhere it asks people to completely stop eating fats.

furthermore i run dieting app with thousands of users so i am not the one who is going to promote zero sugar or fat diet.

My app: https://macrocodex.app/

it's an ad free, subscription free app, i don't make money from this.

Re: What Ozempic does to the gut-brain axis

#243

Post by phil21 »

y-curious wrote: post #6

I got severely downvoted in the past for badmouthing GLP1s here. Then I did my research, got on them and I take it all back. These things are on par with statins in terms of potential societal impacts.

> These things are on par with statins in terms of potential societal impacts.

I put them just under antibiotics. In terms of quality of life years given back at a population scale.

Re: What Ozempic does to the gut-brain axis

#244

Post by nemomarx »

hack1312 wrote: post #220
nemomarx wrote: post #216

Earlier quoted context omitted.

Diets also don't stick when you discontinue them. It would be an incredible advancement if we figured out a reliable and replicatable way to just eat less food, but until then I think a drug that makes you do that is pretty decent.

> Diets also don’t stick when you discontinue them. Yes, obviously. Which is why sustainable weight loss takes a commitment to making a change in lifestyle. What’s more sustainable, changing your lifestyle to maintain the weight you lost, or being beholden to taking a drug to maintain that same lifestyle change for a hope at maintenance?

From the last time I looked at studies on basically any diet, I think prescribing people drugs for life probably lasts longer. Do you have any longitudinal studies of people making lifestyle changes for 10+ years to keep off weight?

Re: What Ozempic does to the gut-brain axis

#245

Post by wincy »

phil21 wrote: post #120
Aaargh20318 wrote: post #75

Earlier quoted context omitted.

That’s the problem with these new weight loss drugs. Ultimately they work by reducing food intake. For many people food is one of the few things in life that gives them some form of joy. I won’t ever take any drug that will take that away from me. Life is depressing enough as is. What we need is a weight loss drug that lets you eat unlimited amounts of food, preferably even suppressing the feeling of fullness, withou…

I dunno. It’s not universal, but I have a newfound joy when it comes to food after being on a GLP-1 and losing about 100lbs. Sure, I don’t get the instant giant dopamine spikes from binge eating $30 worth of Taco Bell or a couple large pizzas. Once in a while I do miss that, but I can still do it now that I’m a few years into the weight staying off. It’s just not worth how shit I feel the next couple days afterward.…

You and I are kindred souls here buddy, I haven’t had heartburn in months and it used to be an almost daily occurrence. When it does occur it’s fixed by one Tums. I’ve lost 120 pounds taking Zepbound. My life used to be Waking up and downing half a bottle of Pepto because my stomach was an acid volcano. Doctors telling me that it’s just the way my life is now, and to take PPIs. Eating a pizza in one sitting. Feeling the urge at 11pm to go get fast food after eating dinner because I was so hungry. Now if I get Taco Bell it’s like $8 and it still tastes good, but I tucked into cauliflower and Caesar dressing as a snack today instead.

Totally transformative.

Re: What Ozempic does to the gut-brain axis

#246

Post by topgrain2 »

hack1312 wrote: post #220
nemomarx wrote: post #216

Earlier quoted context omitted.

Diets also don't stick when you discontinue them. It would be an incredible advancement if we figured out a reliable and replicatable way to just eat less food, but until then I think a drug that makes you do that is pretty decent.

> Diets also don’t stick when you discontinue them. Yes, obviously. Which is why sustainable weight loss takes a commitment to making a change in lifestyle. What’s more sustainable, changing your lifestyle to maintain the weight you lost, or being beholden to taking a drug to maintain that same lifestyle change for a hope at maintenance?

The drug is more likely to work long-term. Diet & exercise, as a treatment plan, are distressingly ineffective.

Well-studied problem.

It makes more sense when you realize that something like sheer dieting/exercising willpower isn't why some populations are skinnier than others. Pick another country with a healthier-weight population, start placing some of them in the US, and they'll gain weight. Put them back, and it'll drop again.

If "just diet and exercise" (the advice, and individual effort to that effect) aren't what are keeping some populations skinnier, why would it cure a population with an obesity epidemic?

Re: What Ozempic does to the gut-brain axis

#247

Post by phil21 »

declan_roberts wrote: post #185
cjbgkagh wrote: post #49

Earlier quoted context omitted.

I get mine on the black market, 50c/mg for semaglutide, $3 per month at my current rate of usage. I’ve been on it for years, I was getting gray market at $12/mg for 3 years before RFK clamped down on that market. It’s exactly the same stuff (for me, no guarantee for others), had it tested in a lab and as the side effect profile is on point. It massively relieved my ME/CFS, back when I started there was no way I could…

GRAY market is way undercounted in peptide use. Go to the gym and there's like 25% of the people there taking gray market peptides (some for weight, some for injury repair, etc)

That would be black market, almost assuredly if you are talking about "injury repair" peptides. Exceedingly few prescribers in the US are writing for those.

Grey market references stuff like HIMS where you are getting a real doctor to write you a prescription and a shady compounding pharmacy takes those Chinese black market peptides, compounds them, and ships them to your door.

Black market is just going direct to the source in China and getting them for yourself without a prescription.

Re: What Ozempic does to the gut-brain axis

#248

Post by netheril96 »

Barrin92 wrote: post #223
crooked-v wrote: post #154

Earlier quoted context omitted.

For many people, the "underlying issue" is fundamentally just being too hungry for how they live. GLP-1s absolutely treat that.

> the "underlying issue" is fundamentally just being too hungry for how they live operative phrase in that sentence "how they live". They need to live more active lives. And that's better than a weight loss drug because inactivity causes systemic disease beyond weight gain. GLP-1 drugs do to hunger what pain meds do to pain, but if you're overweight and your back is aching because you're sedentary the solution isn't…

> They need to live more active lives.

When I become more active, I also become more hungry due to the extra energy consumption. The net effect is little weight loss and more often than not weight gain. While being physically active is beneficial to health in many ways, it does little for losing or maintaining weight, at least for me.

Re: What Ozempic does to the gut-brain axis

#249

Post by faangguyindia »

toast0 wrote: post #203
faangguyindia wrote: post #158

Earlier quoted context omitted.

for many people the underlying issue is serious lack of education when it comes to nutrition. Not understanding calorie balance, not understanding calorie density of the food they eat. How many people know 1kg fat = 7700kcal that if they could create deficit of 7700kcal they could potentially lose 1kg bodyfat? Ofc, i know the relationship isn't that simple but for most people this roughly holds true. If you are eatin…

Plenty of people can take this intelectual knowledge and turn it into eating behaviors that work for them. But this intelectual knowledge doesn't really help if your body is telling you it's hungry all the time and it's hard not to eat something . Better choices can help, because different calories deliver different satiety; but some people don't get much satiety no matter what they eat. Calories in vs calories out i…

>But this intelectual knowledge doesn't really help if your body is telling you it's hungry all the time and it's hard not to eat something. Better choices can help, because different calories deliver different satiety; but some people don't get much satiety no matter what they eat.

Maybe try to figure out why you’re feeling hungry. Is it because you’re running a 1000 kcal deficit?

Can your body really tell whether you ate 200–300 kcal less today than you did yesterday?

Most of us can easily notice a 1000 kcal difference, but very few can reliably detect a day-to-day difference of just 200–300 kcal.

What are your maintenance calories? Are they around 1800 kcal, where even a 300 kcal deficit puts you on a 1500 kcal diet? That’s very little food for many people.

In that case, it may be better to focus on increasing your maintenance calories by becoming more active in daily life.

Deficit = TDEE - Intake

either drop intake or boost tdee or do both.

If you managed to boost your tdee to 2500kcal, now a deficit of 300kcal means you eat 2200kcal day to day and 2200kcal isn't very little food making diet easy to follow.

>There's a lot of variance among humans, but everybody seems to want a one size fits all approach to eating.

I think there isn't as much variance as people like to believe, how many people you see walking around you with 3 eyes? and 4 hands?

Re: What Ozempic does to the gut-brain axis

#250

Post by dotcoma »

Aaargh20318 wrote: post #75
9x39 wrote: post #55

Earlier quoted context omitted.

If they were a normal weight they would not have been prescribed the drug. The underlying issue is they're overweight because they eat too much. Anything more is speculation. There is usually no free lunch when it comes to pharma, and extrapolating long term or lifetime dependence as being equivalent to short term interventions is an unsupported leap.

That’s the problem with these new weight loss drugs. Ultimately they work by reducing food intake. For many people food is one of the few things in life that gives them some form of joy. I won’t ever take any drug that will take that away from me. Life is depressing enough as is. What we need is a weight loss drug that lets you eat unlimited amounts of food, preferably even suppressing the feeling of fullness, withou…

> For many people food is one of the few things in life that gives them some form of joy.

This is the problem to be addressed, not hoping for a miracle drug that will let you chuck down 5,000 calories a day and be healthy, imho.

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