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Heavy marijuana use increases schizophrenia in men, study finds

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Re: Heavy marijuana use increases schizophrenia in men, study finds

#241

Post by dataangel »

skissane wrote: post #188
kitanata wrote: post #80

You have these cells in your brain called Microglia. They are responsible for cleaning up neurons and plaques and other weird proteins. These Microglia are activated by the firing neurons which release 2-AG and AEA (Anadamide). AEA binds to the CB1 receptor in these Microglia. 2-AG binds to CB2. THC binds to CB1. CBD binds to CB2. Autistic adults have significantly low blood serum levels of AEA. Autistic people’s neu…

> Autistic adults have significantly low blood serum levels of AEA. Autistic people’s neurons prune slower. Schizophrenic people’s neurons prune faster. These are all group-level findings, meaning they aren't true for every individual. You can do a study and find that there is a statistically significant difference in mean X between two samples – autistic vs control or schizophrenic vs control. But pretty much always…

> This is why a number of researchers have been arguing that diagnosis-centric research is a dead-end.

Just sounds like they've been diagnosing by symptom because they didn't know the actual etiology. Once it's known shouldn't they just change the diagnosis to be the new, more specific condition? Seems like diagnosis is still the goal?

Re: Heavy marijuana use increases schizophrenia in men, study finds

#242

Post by Zircom »

mise_en_place wrote: post #237
coffeebeqn wrote: post #211

Earlier quoted context omitted.

I wonder if that’ll be the case for AI?

AI will never have qualia so no. The closest you’ll get is something like LLama-7B hallucinating output.

Maybe they won't ever experience the same set of qualia humans do, but I don't think it's out of the question to say they won't have their own set of qualia that are just as inscrutable to humans as ours are to them.

Re: Heavy marijuana use increases schizophrenia in men, study finds

#243

Post by jb1991 »

MagicMoonlight wrote: post #183
csomar wrote: post #175

Earlier quoted context omitted.

My understanding is that schizophernia is a predisposed condition. Cannabis can trigger it but not really cause it. (That's at least what I got from talking to a professional). One clue to find out whether you are predisposed is if you have someone in the family (related genetically) who has at-birth mental health issues. Then stay a gazillion miles clear of any drugs.

If you don’t have it and then taking it makes you have it then that is causing it

Does a freezer make ice, or does water make ice?

Re: Heavy marijuana use increases schizophrenia in men, study finds

#244

Post by andreskytt »

mandmandam wrote: post #163
denton-scratch wrote: post #104

Earlier quoted context omitted.

Empirically (based on my own observations) I've known for decades that weed induced episodes in schizophrenic people. I didn't know it was helpful for autistic people. On the same (personal observation) basis, I'd say that schizophrenic people are drawn to cannabis. I have no idea why; perhaps because they're often very marginalized and precarious.

> schizophrenic people are drawn to cannabis. I have no idea why I think that there are a number of reasons for this. CBD, exploration/play of mental states, and the hundred+ other cannabinoids may all be a factor. First, cannabis can contain CBD, which has strong, known anti anxiety and anti-psychotic effects. Couldn't a person vulnerable to episodes recognize this effect when enjoying a higher CBD strain, then seek…

Ah, the old shaman argument. The dude living in an essentially black-and-white wasteland up north with months of darkness. He strongly believes in the need to go consult the ancestors, moves in a hypnotic fashion, beats a monotone rythm on the drum for hours staring into a fire. And thus needs a minuscule plant-based push to have a profound experience. And still the old stories always have the element of being very careful and struggling to return from the other side. And then there’s a modern everyday flashing-lights-and-technicolor life kind of dude just looking to have some fun. The context is too different for “they did it thus it’s natural” argument to work.

Re: Heavy marijuana use increases schizophrenia in men, study finds

#245

Post by dang »

dooglius wrote: post #130
dang wrote: post #74

Earlier quoted context omitted.

" Please don't post shallow dismissals, especially of other people's work. A good critical comment teaches us something. " " Avoid generic tangents. " https://news.ycombinator.com/newsguidelines.html

It's not shallow at all, and the above comment teaches more than the wild speculation and anecdotes many of the other top-level comments have.

It counts as a shallow dismissal because it was (a) generic and (b) an oft-repeated internet cliché.

You could in fact replace "cannabis" and "schizoprehnia" with "foo" and "bar" and you'd have a template for a shallow dismissal of published studies.

Re: Heavy marijuana use increases schizophrenia in men, study finds

#246

Post by dang »

amanaplanacanal wrote: post #84
dang wrote: post #74

Earlier quoted context omitted.

" Please don't post shallow dismissals, especially of other people's work. A good critical comment teaches us something. " " Avoid generic tangents. " https://news.ycombinator.com/newsguidelines.html

Sorry for my cranky comment.

Appreciated!

Re: Heavy marijuana use increases schizophrenia in men, study finds

#247

Post by operatingthetan »

piperswe wrote: post #239
operatingthetan wrote: post #133

Earlier quoted context omitted.

Plus that combo gives guaranteed insomnia. The user wakes up from whatever sleep they did get, takes the speed again, and it's like nothing happened. This continued loss of sleep compounds over time and can contribute to psychosis.

For some with ADHD, stimulants can have a neutral or positive effect on sleep. I know I can have the best, calmest naps after I've taken Vyvanse. Therefore, I wouldn't say "guaranteed" insomnia. Once it wears off though, my sleep's not great. At least it's no worse than it was before starting medication, I've just never been able to sleep well.

>For some with ADHD, stimulants can have a neutral or positive effect on sleep. I know I can have the best, calmest naps after I've taken Vyvanse. Therefore, I wouldn't say "guaranteed" insomnia.

You're talking about half the the drug combo in question, I'm not sure that's a useful anecdote. As I said to others, I would not recommend adding weed to your vyvance though, unless you are interested in personally experiencing the topic of this thread.

Re: Heavy marijuana use increases schizophrenia in men, study finds

#248

Post by alephu5 »

spicyusername wrote: post #177

Can we please stop making marijuana so strong. I already cut my marijuana with 50% CBD, and that's still plenty strong that I only need a single hit to be plenty high. I can't for the life of me understand why there's a race to the highest imaginable THC percentage, when it so clearly has an adverse effect on the experience.

I imagine the people paying the most money have a high tolerance.

Re: Heavy marijuana use increases schizophrenia in men, study finds

#249

Post by Haga »

skissane wrote: post #208
dragonwriter wrote: post #204

Earlier quoted context omitted.

> (Hans Asperger famously used Autism diagnoses to euthanize children, that's who "Asperger's Syndrome" is named after!) Asperger was assigned to identify autistic children for exterminatiom, but mafe the case that certain ones were useful to the Reich, which is why “Asperger’s Syndrome” became the name for the manifestation of autism that was seen as a leader impairmemt.

He wasn't assigned to identify "autistic children" specifically for extermination. Hans Asperger was a psychiatrist. Psychiatrists in Nazi Germany (post-Anschluss Austria in his case) were expected to evaluate all of their patients for potential extermination, children included. Some psychiatrists refused to cooperate with the regime, at great personal cost to themselves. Other psychiatrists signed up to become enthu…

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Re: Heavy marijuana use increases schizophrenia in men, study finds

#250

Post by Haga »

whats_a_quasar wrote: post #41

There's a really interesting line of research that suggests Schizophrenia is a spectrum, rather than a binary. Lots of people have personality traits that are similar to schizophrenics or have genetic risk factors for the condition. Some of those people develop the full disorder, and some don't. There's evidence that the reason for the split is that psychosis is itself damaging. Once someone has a psychotic episode,…

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