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Melatonin: Much More Than You Wanted to Know

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241–250 of 268 posts

Re: Melatonin: Much More Than You Wanted to Know

#241

> Yes. Most existing melatonin tablets are around ten to thirty times the correct dose. I couldn't find an explanation why they'd be sold at this dose from this article, which makes me suspicious of this. Am I missing something? What would be the motive for this?

Europe. I get mine melatonin tablets there. Just stock up for a year. Small bottles to bring back. Never had an issue through customs.

Re: Melatonin: Much More Than You Wanted to Know

#242

As someone who works from home 90% of the time and sleeps/works in a room with a huge skylight, I've never had better sleep, energy, and overall "consistency" with my body. The most notable issues being that I actually feel sleepy when it's time to sleep, and I can fall asleep within minutes. I've never really experienced that before. I used to work nightshifts with mostly light-blocking shades, and the only natural…

That's ok if you're living close to the equator with a regular day/night schedule. But if living more towards the poles then you get extremes in winter and summer of how much light/darkness there is.

Re: Melatonin: Much More Than You Wanted to Know

#243
post #192
post #161

Earlier quoted context omitted.

I am sharing my experience because I know how awful sleep problems can be. I'm in my 30s and eat what many consider a very healthful diet - virtually no sugar, just veggies, high quality fats and proteins, and minimal fruit. I spend 7-9 hours in bed; yet wake up feeling exhausted every. single. day. I'd love to exercise, but I'm too continuously tired to get started. Melatonin, when taken via dissolving sublingual ta…

This is going to be a totally anecdotal post: In my twenties I had the same problem when waking up, slept 7-8 hours, worked out, good job, super healthy diet but woke up exhausted, miserable, and borderline depressed 9/10 days. It took two years and lot of blood tests over time but turns out I had Hashimoto's disease, which lead to hypothyroidism. It is rare for someone in their 20s but I guess I beat the odds :), al…

I feel the same way brother. And it took me 10 years to diagnose it. Just took one good GP

Re: Melatonin: Much More Than You Wanted to Know

#244
post #153

Couple anecdotal points: - Used to have to sleep problems - mainly just my mind racing with all the (stress of) things I had to do. The symptoms were trouble sleeping and/or waking in the middle of the night with instant thoughts of projects, task lists. - Melatonin didn't help me much. Maybe their effect was too subtle on me - maybe I was using the wrong dose as mentioned in the post. - Magnesium Glycinate pills bef…

Let's keep the magnesium training rolling.

NOW ZMA [1] has been my life saver for years. It never fails to make me enter "sleep mode". The same dose works now as has always worked. Do not take calcium supplements at the same time as ZMA.

[1] https://www.amazon.com/dp/B0013OZGQ0/r

Re: Melatonin: Much More Than You Wanted to Know

#245

Earlier quoted context omitted.

The take-away from that sounds as if you found a sleeping-mask helpful, but there's not much evidence that melatonin had any effect.

> The take-away from that sounds as if you found a sleeping-mask helpful, but there's not much evidence that melatonin had any effect. How can you reasonably conclude anything from your position, having only read that short comment? They have all the context and data and came to their conclusion. It might or might not be correct, but you're in no place to refute them on the topic of what has helped them personally.

I was merely basing on the description as given. If there's more context, it wasn't really given.

Re: Melatonin: Much More Than You Wanted to Know

#246
I will always sing the praises of Trazodone for dealing with sleep issues. It worked extremely well for me and my parents. It's normally used at very large doses as a last line for clinical depression. However at smaller doses it's an extremely effective sleep aid for some people. It also doesn't make you to sleepy like other drugs. It just makes getting to sleep easy.

Re: Melatonin: Much More Than You Wanted to Know

#247

Earlier quoted context omitted.

I'm fairly sure I tried somewhere around .3mg 4 hours before bed and it still woke me up (and I couldn't get back to sleep for hours). I just recently tried .3ish mg (scooped from powder this time so not very precise, next time I'll try the water mixing trick that someone here suggested) 7 hours before bed for five days and it still seemed to wake me up more than usual (but I also took other stuff with it and was abl…

Also, I do have concerns about the quality control and dosage accuracy of these supplements. There was a study that tested OTC melatonin products in Canada and found: > Results show that melatonin content did not meet within a 10-percent margin of the label claim in more than 71 percent of supplements, with the actual content ranging from 83 percent less to 478 percent more than the concentration declared on the labe…

Good point, that would certainly confuse the situation if there was a 5x variation. Even though they aren't treated the same as drugs there are still quailty standards in the US, although they don't seem to be enforced very well. I try to find suppliers that do better testing. If you have the money for FDA approved stuff you can get ramelteon or tasimelteon these days. But they are quite expensive. Although it looks like the ramelteon patent expires next year and there are a couple of approved generics already so prices should go down quickly next year:

https://www.drugs.com/availability/generic-rozerem.html

I got 1g pure melatonin powder from a now gone supplier that did good quailty testing. It takes me several tries to get something that looks like about .3mg since it is such a tiny amount and I'm sure there is quite a bit of variation, but I'm fairly sure I at least get < .5mg each time.

Re: Melatonin: Much More Than You Wanted to Know

#248
post #229

Earlier quoted context omitted.

Uh not really. Most fruit is both low to medium GI and GL. Sugar in fruit is bound to fiber and bloodstream uptake is fairly slow. There is a negative correlation between RDA fruit consumption and diabetes.

Correlation does not equal causation. People who generally eat less fruit are people who usually ignore health advice in general, and would replace fruit with stuff like sugar or carbs. Eating too much fruit gives an overload of fructose, which also triggers an insulin response. If you eat the right meats, like liver, you get more vitamins and minerals then you would from fruit. So if you know what you are eating, it…

>Eating too much fruit gives an overload of fructose,

Note the operative modifier 'too much'

You can eat your recommended daily intake of fruit in one sitting with no other food and still remain below high GL levels.

Digestion is a complex process. Your model that anything containing fructose is bad is not supported by any data / analysis I am aware of, and contradicted by nearly all of it.

Mammals process most of thier fructose consumption in their small intestines. Only high doses that overload this capacity lead to harmful spillover to the liver etc.

Re: Melatonin: Much More Than You Wanted to Know

#249
post #230

Earlier quoted context omitted.

>fruit is not healthy for you https://academic.oup.com/ajcn/article/105/6/1462/4569801 Fruit consumption is inversely correlated with all-cause mortality as best we can tell. Probably something to be said about people who eat fruits being among the more health minded individuals as well and skewing results but it’s probably not “unhealthy” to eat fruits.

Correlation doesn't mean cause. Otherwise you would draw conclusions like divorce rates in Maine affected by margarine consumption. https://tylervigen.com/view_correlation?id=1703 People consuming fruit could be more healthy individuals in general, exercising and avoiding other types of food which might have more effect than consuming fruit. So be careful about drawing conclusions from correlations or epidemiological…

But I didn’t imply causation? I literally gave the same “could be skewed due to healthier lifestyle choices” in my comment...

Re: Melatonin: Much More Than You Wanted to Know

#250
post #86
post #80

Earlier quoted context omitted.

How much do you take? I was regularly taking 3mg and 1.5mg regularly for most of the past 4 years. I recently tried 0.3mg (as recommended in another recent HN discussion about melatonin, I think it was a week or 2 ago), and I had terrible results. On 1.5mg and 3mg, I would have very unsettling and memorable dreams, as well as wake up very tired, but I would get at least 7 hours of sleep on most nights. With 0.3mg, I…

D3 should be taken for small periods. Note that these supplements, do not make up for self-produced substances. I would like to ask you if instead of using melatonin to enhance your sleep, did you try physical exercise. If your body is physically tired and you abstain from screens (iPads, iPhones, etc.) for 2h before sleeping, you should be able to get a decent amount of sleep. Additionally, sleep quality doesn’t tra…

Sooo doing some exercise 2 hours before sleeping and not spending my last waking hours on my laptop did it. I got more than 7 hours of sleep for sure, and...also woke up feeling very tired. I know I have a huge sleep deficit built up, so that's fine. I'm hoping I can sleep as much tonight as well.
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