I think there's a pretty simple explanation for this. How many calories should you consume per day?
It's a trick question because it has no answer. It's going to vary dramatically depending upon environmental, physical/physiological, and genetic characteristics. And that is probably the most simple question to answer, because when you get into the specifics of nutritional content, the same is true except it's orders of magnitudes more complex with far less understood.
And many things come down to pretty precise measurement because it's all systems in equilibrium. 100 calories to your diet would ostensibly have a negligible impact because it's not much relative to your entire intake, but if you were just at the equilibrium where your consume - burn = 0, then that 100 calories is suddenly going to start seeing you gain weight dramatically faster than before.