201–210 of 251 posts
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No tradeoffs? I don't think such a thing exists. Aspirin kills people every year. The only pain reliever I know of that has never killed anyone is cannabis. I don't think it does much for fever though?
Inhaling smoke into your lungs is never a good thing. Your lungs (cough) are trying to tell you something.
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Inhaling smoke into your lungs is never a good thing. Your lungs (cough) are trying to tell you something.
Where did I say anything about smoking? And I also didn't say cannabis has no tradeoffs either. But it won't kill you. That's a pretty strong pro in my book if you are looking for occasional pain relief.
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> OTOH acetaminophen is known to be toxic This is news to me. What exactly does "toxic" mean? Do you have a citation I can read? Acetaminophen is not for inflammation anyway.
Paracetamol (or acetaminophen) can cause liver failure if you take too high a dose[1] (this is one of the reasons you are told not to drink alcohol when taking paracetamol -- if your liver is struggling to process alcohol you're more susceptible to liver failure). In fact, paracetamol poisoning is the primary cause of death in overdoses (in the US, UK, Australia and New Zealand)[2]. And in 2006, [3] found it was the…
Sure, and drinking too much water causes hypernutremia that can also kill you. Toxicity is always dose dependent, so the initial unqualified claim seemed to imply toxicity at normal dosages.
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> At normal doses, Acetaminophen can trigger Stevens-Johnson Syndrome Probably not: https://www.ncbi.nlm.nih.gov/m/pubmed/28963996/
In my case, it does.
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> OTOH acetaminophen is known to be toxic This is news to me. What exactly does "toxic" mean? Do you have a citation I can read? Acetaminophen is not for inflammation anyway.
Paracetamol (or acetaminophen) can cause liver failure if you take too high a dose[1] (this is one of the reasons you are told not to drink alcohol when taking paracetamol -- if your liver is struggling to process alcohol you're more susceptible to liver failure). In fact, paracetamol poisoning is the primary cause of death in overdoses (in the US, UK, Australia and New Zealand)[2]. And in 2006, [3] found it was the…
This doesn't really undercut anything you say, but if I was given accurate information I assume a subset of those acetaminophen OD deaths are from people abusing painkillers it's combined with. I haven't looked into it, but I assume this is also a partial explanation of why OTC cold medications with Dextromethorphan in them tend to be combined with a relatively high dose of acetaminophen. I would guess there are other good examples of abusable pharmaceuticals combined with acetaminophen.
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Kratom / Cannabis oh wait these are illegal so big pharma can milk their poisons.
Here in Canada, Big Pharma are falling over themselves to get into the Cannabis business. I honestly think the obstacle to Cannabis legalization in the US is social conservatism, not industrial lobbying.
600mg per day is an enormous dose, albeit not especially uncommon. I’d be more interested though in the effects of, say, 200 - 400mg per week.
I recently went to the doctor with a shoulder strain and without even looking at it he prescribed 1000mg daily for 2 weeks then "come back if it still hurts".
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OTOH acetaminophen is known to be toxic; is there an alternative here for non narcotic inflammation, fever, and pain relief that is shown NOT to have tradeoffs for use?
Naproxen / Aleve?
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Paracetamol (or acetaminophen) can cause liver failure if you take too high a dose[1] (this is one of the reasons you are told not to drink alcohol when taking paracetamol -- if your liver is struggling to process alcohol you're more susceptible to liver failure). In fact, paracetamol poisoning is the primary cause of death in overdoses (in the US, UK, Australia and New Zealand)[2]. And in 2006, [3] found it was the…
I can't cite a source, but I recall being told when I was prescribed a few days of vicodin+acetaminophen after an appendectomy that acetaminophen is (often? sometimes? always?) combined with some potentially-addictive painkillers to limit the extent to which they can be abused without the user needing treatment for liver issues. This doesn't really undercut anything you say, but if I was given accurate information I…
However, there's a more important medical reason: acetaminophen accentuates the analgesic affects of opioids, although the mechanism for this is not clearly understood. This makes acetaminophen-enhanced opioids more effective drugs.
Opioid abuse has become so rampant, though, that we're moving away from prescribing acetaminophen-enhanced opioids like Vicodin and Percocet to try to stop them entering the recreational drug market. As opioid use has increased, so has the number of liver toxicity deaths due to the acetamiophen in some prescription opioid drugs.
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In curious how can they make a statement such as “the study cannot be used to draw any conclusions” without providing any kind of reasoning, and get published in Nature?
Whenever I see blanket statements like this in such studies ~ it's like they're trying to avoid pissing any powerful corporations that profit from whatever we're told to not draw any conclusions about. They don't want to potentially endanger their careers. Drug companies hate it when a cash-cow drug is threatened in any way. Anything that threatens those profits is a potential target in one way or another. Researcher…
Understanding people's incentives will often result in reasons to be suspicious, but suspicions aren't evidence and it's not a shortcut for understanding the science.