Earlier quoted context omitted.
> blind people are never Schizophrenic That is an interesting observation. Do you have a source?
https://www.psychologytoday.com/blog/the-imprinted-brain/201...
Thank you, very exciting.
Nicotine Normalizes Brain Activity Deficits That Are Key to Schizophrenia
201–210 of 246 posts
Re: Nicotine Normalizes Brain Activity Deficits That Are Key to Schizophrenia
#202Earlier quoted context omitted.
> Also, there are several MAOIs in tobacco smoke. MAOIs are used as last-line anti-depressants, because of their side-effects when taken in large doses. But with tobacco products, a user basically gets a tritrateable MAOI. Reversible MAOIs are safer than the irreversible ones: https://en.wikipedia.org/wiki/Monoamine_oxidase_inhibitor#Re... There were some articles in the Boston Globe in 2000 that pointed out that the…
I've always wondered: how do they establish a drug causes suicide? I mean they're not literally giving people suicidal thoughts. How do they make people more prone to suicide?
As far as I'm aware, the currently prevailing theory is that many deeply depressed people may be be having suicidal thoughts, but their depression is also so strong that they don't have the energy and/or motivation to actually go through with it. Apathy is winning. As the drugs start to lift you out of the hole of apathy, you suddenly start to have more energy and motivation, but you're still depressed. So you still are suicidal but now you have the ability to go through with it.
Re: Nicotine Normalizes Brain Activity Deficits That Are Key to Schizophrenia
#203Earlier quoted context omitted.
I tried a bunch of supplements and herbs. Some worked, some had nasty side effects, and most did squat. The short list is I tried: Piractem, GABA, Rhodila Rosea, Cocamine (chocolate extract), gluractone (red bull ingredient), various ephedrine like stuff, various methly caffeine things (ie green tea), Yohimbine (I highly recommend you never ever take this). I used to have lab like jars of the stuff at work and my cow…
Yohimbine is a horrible experience. Used clinically to induce anxiety attacks, and does so very well.
Wow, why would you want/need to induce an anxiety attack?
Re: Nicotine Normalizes Brain Activity Deficits That Are Key to Schizophrenia
#204Earlier quoted context omitted.
I've always wondered: how do they establish a drug causes suicide? I mean they're not literally giving people suicidal thoughts. How do they make people more prone to suicide?
As far as I'm aware, the currently prevailing theory is that many deeply depressed people may be be having suicidal thoughts, but their depression is also so strong that they don't have the energy and/or motivation to actually go through with it. Apathy is winning. As the drugs start to lift you out of the hole of apathy, you suddenly start to have more energy and motivation, but you're still depressed. So you still…
This sounds like an apologist's explanation for an inconvenient truth. Sounds reasonable, but falls apart when confronted with actual data.
(Edit: I'm sure you were paraphrasing what you'd read somewhere.)
Here's a quote from the Boston Globe's 5/7/2000 article:
>> Three years before Prozac received approval by the US Food and Drug Administration in late 1987, the German BGA, that country’s FDA equivalent, had such serious reservations about Prozac’s safety that it refused to approve the antidepressant based on Lilly’s studies showing that previously nonsuicidal patients who took the drug had a fivefold higher rate of suicides and suicide attempts than those on older antidepressants, and a threefold higher rate than those taking placebos.
>> Lilly’s own figures, in reports made available to the Globe, indicate that 1 in 100 previously nonsuicidal patients who took the drug in early clinical trials developed a severe form of anxiety and agitation called akathisia, causing them to attempt or commit suicide during the studies.
-- http://ahrp.org/prozac-revisited-concerns-about-suicides-sur... (I don't know anything about this site, but I've read the quote elsewhere so I'm sure it's a true copy of what the Globe actually printed).
Re: Nicotine Normalizes Brain Activity Deficits That Are Key to Schizophrenia
#205Earlier quoted context omitted.
So... bear with me: Patient comes in and says "I noticed that nicotine helps with my symptoms." Doctor does some searches & reading and sees no results (because this study hadn't been published yet). Doctor tells patient, "There is no published, scientific evidence between nicotine use and treatment of schizophrenia. But there is evidence that smoking is bad." That seems perfectly reasonable for a practicing doctor b…
A reasonable reaction would be 'tell me about the difference it makes to your symptomology' and maybe helping the patient figure out a way to track this systematically. Likewise I would have thought that mentioning my extensive experience of psychedelic drugs (also now suddenly fashionable) would have merited something other than 'uhuh', such as questions about how the temporary improvement in mood manifested or how…
That reaction makes a lot of sense. Indeed, that would be the most effective method!
Re: Nicotine Normalizes Brain Activity Deficits That Are Key to Schizophrenia
#206This makes me wonder what the modern world would look like if all "recreational drugs" suddenly disappeared, and so all the people who were implicitly, unknowingly self-medicating for a mental illness by using recreational drugs, suddenly weren't. What percentage of the population would go from seemingly neurotypical, to perceivably mentally ill? How much more common would conditions like schizophrenia be?
The older I get, the more "neurotypical" becomes synonymous for capitalism-compatible.
No matter the size of your parachute/coping mechanism, if you fall on Jupiter, it's not the (decelerated) fall that kills you, it's the jostling torture of simultaneously hitting fluid from under you, and being crushed by the weight of fluid above.
Re: Nicotine Normalizes Brain Activity Deficits That Are Key to Schizophrenia
#207Earlier quoted context omitted.
I tried a bunch of supplements and herbs. Some worked, some had nasty side effects, and most did squat. The short list is I tried: Piractem, GABA, Rhodila Rosea, Cocamine (chocolate extract), gluractone (red bull ingredient), various ephedrine like stuff, various methly caffeine things (ie green tea), Yohimbine (I highly recommend you never ever take this). I used to have lab like jars of the stuff at work and my cow…
Out of curiosity, what was your experience with Yohimbine? Why was it so bad?
What's a duct-ape and how did you learn to control them?
Re: Nicotine Normalizes Brain Activity Deficits That Are Key to Schizophrenia
#208Earlier quoted context omitted.
Why not just get more, higher quality sleep? It provides all of the upsides that you mention with no downsides.
You make it sound as though sleep quality were something everyone has control over, which is not at all the case.
Actually, most people could get more sleep of they chose to. Or at least they could get more rest. Stop watching shows and movies, put down your phone, close your eyes, shut up and sleep.
Re: Nicotine Normalizes Brain Activity Deficits That Are Key to Schizophrenia
#209Earlier quoted context omitted.
Because someone who chewed nicotine gum got a cyst we should ban vaping in offices? I'm not sure I follow.
People shouldn't vape in offices for the same reason they shouldn't pass gas. It smells and it's rude.
Are you under the impression that it's possible to not pass gas? I mean, it can be pretty unpleasant, yeah, but I can't actually shut down my digestive system on command.
Re: Nicotine Normalizes Brain Activity Deficits That Are Key to Schizophrenia
#210Earlier quoted context omitted.
> Also, there are several MAOIs in tobacco smoke. MAOIs are used as last-line anti-depressants, because of their side-effects when taken in large doses. But with tobacco products, a user basically gets a tritrateable MAOI. Reversible MAOIs are safer than the irreversible ones: https://en.wikipedia.org/wiki/Monoamine_oxidase_inhibitor#Re... There were some articles in the Boston Globe in 2000 that pointed out that the…
I've always wondered: how do they establish a drug causes suicide? I mean they're not literally giving people suicidal thoughts. How do they make people more prone to suicide?
Drugs are tested on healthy people first. If healthy people with previously no thought of suicide suddenly starts feeling suicidal when in a clinical trial of a drug, it could be outside influence and a huge coincidence, but likely not.