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Paracetamol disrupts early embryogenesis by cell cycle inhibition

academic.oup.com

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Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#21

Post by moi2388 »

“ APAP could contribute to early embryonic loss by impairing initial cell divisions. These results suggest that APAP should be used with caution by women attempting to conceive. Given that cell division is fundamental to all development, further investigation is now warranted”

By the same logic it would now be effective against cancer, no?

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#22

Post by propter_hoc »

tylerhou wrote: post #15
propter_hoc wrote: post #13

[flagged]

> ibuprofen is better in every way. Taking ibuprofen (or other NSAIDs) long-term can wear away the stomach lining, causing ulcers. Acetaminophen is generally better tolerated to manage mild long-term pain than NSAIDs, as long as you don't overdose / take with alcohol.

Yes, you need to take it with food, but it won't cause liver failure.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#25

Post by naijaboiler »

propter_hoc wrote: post #13

[flagged]

This is a dangerous advice. Please folks. disregard this OPs comment. I doubt he is a doctor.

Ibuprofen is not better in every way. Ibuprofen is active in so many different parts of the body at the same time that inevitably it has unintended effects which is more pronounced especially in the elderly. It's bad for stomach, bad for kidneys, bad for mental status. and very bad with long-term use.

TLDR. Both aren't great for different reasons. Tylenol can be acutely OD'd and evidence is starting to show it isn't great embryos. Outside of those 2 situations that can be easily avoided, it is overall less bad than ibuprofen.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#26

Post by propter_hoc »

soVeryTired wrote: post #14
propter_hoc wrote: post #13

[flagged]

> I won't get into the history of why people take so much acetaminophen despite how crappy a drug it is. I'd love if you did. What's the story there?

Basically, the pharma industry's most successful marketing campaign ever. Here's an article from 1982:

https://www.washingtonpost.com/archive/politics/1982/10/02/h...

https://archive.md/rssPI

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#27

Post by odyssey7 »

nine_k wrote: post #2

Basically, paracetamol turns out to be mildly contraceptive, by meddling with cell division cycle. I wonder if it might also slow healing of wounds, or wherever else intense cell division happens.

Unsure if this is related, but I’ve heard that taking painkillers for delayed onset muscle soreness will reduce muscle gains.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#28

Post by epgui »

propter_hoc wrote: post #22
tylerhou wrote: post #15

Earlier quoted context omitted.

> ibuprofen is better in every way. Taking ibuprofen (or other NSAIDs) long-term can wear away the stomach lining, causing ulcers. Acetaminophen is generally better tolerated to manage mild long-term pain than NSAIDs, as long as you don't overdose / take with alcohol.

Yes, you need to take it with food, but it won't cause liver failure.

> take it with food

That's not helpful for the various categories of people who are more prone to gastrointestinal bleeding.

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