Earlier quoted context omitted.
Paracetamol (acetaminophen) - a fairly effective, synergistic, non-addictive, predictably dosed, analgesic.
Which, TTBOMK, we still don't understand the mechanism of at all. But yes, it's fantastic stuff!
ttbomk?
WTH Is Cerebrolysin, Actually?
21–30 of 62 posts
Re: WTH Is Cerebrolysin, Actually?
#22Earlier quoted context omitted.
Paracetamol (acetaminophen) - a fairly effective, synergistic, non-addictive, predictably dosed, analgesic.
It's not addictive, but you gain tolerance. IIRC it's also hard on liver, esp. in combination with alcohol (which js unfortunate since it's otherwise good for hangover).
Correct, makes for a nasty death. ~8 grams and your liver is toast.
Re: WTH Is Cerebrolysin, Actually?
#23Earlier quoted context omitted.
Penicillin, polio vaccine, thorazine, morphine, cisplatin, phenol, arguably semaglutide is the most recent. There have been miracle drugs released every decade or so since the early 1900s. They're just normal now. They stop being a miracle once we're used to them. People used to die of fevers. Of sepsis. And there was nothing that could be done. Let alone cancer.
Oh I forgot about insulin. A little over 1% of the people currently alive would be rapidly dead without it.
[deleted]
Re: WTH Is Cerebrolysin, Actually?
#24> Ever Pharma’s explanation of how the putative peptides in Cerebrolyin cross the blood-brain barrier does not make sense and flies in the face of scientific research which shows that most peptides do not cross the blood-brain barrier It can be considered a benefit from a manufacturer's pov that their product doesn't work. If it did their customers would smarten up and stop buying it. Anyway this looks like your typi…
> It can be considered a benefit from a manufacturer's pov that their product doesn't work. If it did their customers would smarten up and stop buying it.
Even if you are not very smart, doing some tests on yourself seems easy enough. If you pull up any psychology paper on like effecs of CO2 on cognition, and do the tests on yourself, you'd expect to start doing better after a few weeks of taking it, and if not stop. But I think most people that take products to help them improve just go by feel. I read a few nootropics articles back in the day and nobody ever proved any improvement larger than drinking coffee.
Re: WTH Is Cerebrolysin, Actually?
#25Okay, so this miracle drug isn't a miracle either. Which miracle drug is?!?! I'm not asking sarcastically or ironically- I'm sincerely begging for miracles. Anyone??
Rapamycin, maybe metformin - both for life extension and to reduce the incidence of cancer and CVD.
Re: WTH Is Cerebrolysin, Actually?
#26> Pigs were a fortuitous choice due to the fact that they are especially resistant to prion disease Prions is the first thing that came to mind after reading the description. I had not idea pigs are resistant to it. TIL.
Perhaps. I wouldn't believe any statements that I learnt today before some research validating it, and even then only give a measure of confidency. Here I did that for you: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510857/ I trust NIH so my confidence that they write corresponds to truth is high even for the scientific interpretation of truth. And that's what they wrote: > Pigs were considered prion resistant as…
Let pigs eat the central nervous system and nerves of their own race, you'll see that they are subject to ESB and prions. Cannibalism is not healthy for mammals.
Re: WTH Is Cerebrolysin, Actually?
#27Okay, so this miracle drug isn't a miracle either. Which miracle drug is?!?! I'm not asking sarcastically or ironically- I'm sincerely begging for miracles. Anyone??
GLP-1 agonists. https://www.astralcodexten.com/p/why-does-ozempic-cure-all-d... Beyond their somewhat miraculous effects on obesity, they seem to have a wide variety of positive effects even for non-overweight people. They are likely the best and broadest thing we have for stopping negative addictions. They have incredibly positive effects for immune issues. Plus strong early trial results for Parkinson's, Alzheimers…
There’s one dangerous effect of a GLP-1 agonist: delayed emptying of the stomach during surgery. Usually, the stomach should be empty due to the risk of complications (like aspiration). But when one takes a GLP-1 agonist, it is not enough to fast on the same day. When planning surgery, you need to talk with your surgeon. One solution could be to stop taking the agonist seven days before surgery and fast for 24 hours.
There’s an insidious issue: uninformed people tend to quickly assume that the patient is weak-willed and ate even if instructed to come NPO.
Re: WTH Is Cerebrolysin, Actually?
#28Earlier quoted context omitted.
Paracetamol (acetaminophen) - a fairly effective, synergistic, non-addictive, predictably dosed, analgesic.
It's not addictive, but you gain tolerance. IIRC it's also hard on liver, esp. in combination with alcohol (which js unfortunate since it's otherwise good for hangover).
Leading cause of acute liver failure in the US, because the active dose is far closer to the lethal dose than many other OTC drugs. Not clear to me it would actually be approved if it were submitted today.
It is particularly neat because it's not just a pain suppressant, it's a general emotion suppressant.
> ... [it] blunts physical and social pain by reducing activation in brain areas (i.e. anterior insula and anterior cingulate) thought to be related to emotional awareness and motivation. [1]
It also reduces the empathy for pain. [2]
Re: WTH Is Cerebrolysin, Actually?
#29Okay, so this miracle drug isn't a miracle either. Which miracle drug is?!?! I'm not asking sarcastically or ironically- I'm sincerely begging for miracles. Anyone??
GLP-1 agonists. https://www.astralcodexten.com/p/why-does-ozempic-cure-all-d... Beyond their somewhat miraculous effects on obesity, they seem to have a wide variety of positive effects even for non-overweight people. They are likely the best and broadest thing we have for stopping negative addictions. They have incredibly positive effects for immune issues. Plus strong early trial results for Parkinson's, Alzheimers…
The "with diet and exercise" clause is not a joke. You need to think about your nutrition, including protein. Even with a good diet, you're going to lose muscle mass if you don't exercise.