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Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

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Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#21

Post by mantas »

aixi wrote: post #3

Ever since I moved to the 'first world' I've been scared of this disease. We don't have it where I come from and the long term effects sound straight up terrible.

It's super easy to treat if caught early. But that's where the good ends. Vast majority of cases present the infamous circle. But some don't. And if you got the circle in a hard-to-notice spot, it's easy to miss it (it will a month or two into infection) too.

First precaution is to check your legs (and possibly torso/hands) for ticks after passing through high grass. And whole body after coming from the woods. The nasty bit is you may bring ticks home, they stay active for a while and they may bite someone else.

If you get a rash in a weird spot and you've been out in the woods in the past 48 hours, check it out thoroughly. You may have a tick there. I've had countless ticks hiding in weird places that I found due to weird itchy-rashy feeling.

Once you get the tick, remove it in a safe manner asap. Lyme is transferred after the tick is done feeding and about to take off. Which is ~48 hours.

Personally Lyme Encephalitis is much scarier. Not as common, but long term effects are much more likely and even worse. On the bright side, there's a vaccine for it.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#23

Post by mantas »

dovebird wrote: post #19
Thaxll wrote: post #7

Why is it a vaccine? Are there going to be vaccine for everything in the future?

Yes. The beauty of the Vaccine is that it sells on fear. And there is no limit to which a human being can be scared...

Lyme is one of those disease where fear is valid to say the least.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#24

Post by giantg2 »

zz865 wrote: post #17
aixi wrote: post #3

Ever since I moved to the 'first world' I've been scared of this disease. We don't have it where I come from and the long term effects sound straight up terrible.

Me too, and with Zika and Covid I feel like I've gone back to the dark ages of diseases.

That's the cost of fast international travel without health screenings or true quarantines.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#25

Post by ianhawes »

_Microft wrote: post #14

Prepare to read the headline "mRNA vaccine trial for " a lot in the future. My guess is that they are going to produce mRNA versions of basically any vaccine (and then some) in the future. The nice thing about the technology seems to be that you only need to exchange the mRNA payload while the surrounding delivery method can be reused. That makes it not only a fast method to create a vaccine but a very convenient way…

The biggest investment that Pfizer made was the creation of a way to reliably manufacture mRNA vaccines. Now they must recoup those investments.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#27

Post by thatcat »

snemvalts wrote: post #6
aixi wrote: post #3

Ever since I moved to the 'first world' I've been scared of this disease. We don't have it where I come from and the long term effects sound straight up terrible.

It's nothing compared to the other tick disease: tick borne encephalitis. Thankfully there's a vaccine against that

Though it's not available in the US.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#28

Post by honksillet »

_Microft wrote: post #14

Prepare to read the headline "mRNA vaccine trial for " a lot in the future. My guess is that they are going to produce mRNA versions of basically any vaccine (and then some) in the future. The nice thing about the technology seems to be that you only need to exchange the mRNA payload while the surrounding delivery method can be reused. That makes it not only a fast method to create a vaccine but a very convenient way…

Does anyone know why they haven't released a Delta varient vaccine? Is seems that it would just involved we changing the mRNA sequence in a computer at the factor, but I'm really just guessing. Also maybe it is considered a whole new vaccineand needs to go through approval again.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#29

Post by ad404b8a372f2b9 »

_Microft wrote: post #8
happyhardcore wrote: post #4

Can anyone give some insight as to why a vaccine hasn't been possible using more traditional technology?

There was one but it was taken off the market. It's a bit of a sad story because it worked but because of unfounded claims that it had side effects, it lost trust of the public: "In clinical trials involving more than 10,000 people, the vaccine, called LYMErix, was found to confer protective immunity to Borrelia in 76% of adults and 100% of children with only mild or moderate and transient adverse effects. [...] Subs…

Unfounded claims from 100s of people developing imaginary autoimmune disorders? Mind you people are still getting compensated in court for autoimmune disorders arising from the Hep-B vaccine, even though no causal link was found. Just yesterday I had to accompany my sister to the phlebologist, because of severe side-effects from Pfizer, he told us he was seeing troves of patients for similar reasons even though officially no causal-link was established.

At some point you have to wonder if health-policy takes precedence over truthful reporting when it comes to vaccines. (I'm "pro-vax" btw, I was the one who convinced my sister to go take her dose even though she's quite young. Now I feel like a moron.)

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#30

Post by giantg2 »

mantas wrote: post #21
aixi wrote: post #3

Ever since I moved to the 'first world' I've been scared of this disease. We don't have it where I come from and the long term effects sound straight up terrible.

It's super easy to treat if caught early. But that's where the good ends. Vast majority of cases present the infamous circle. But some don't. And if you got the circle in a hard-to-notice spot, it's easy to miss it (it will a month or two into infection) too. First precaution is to check your legs (and possibly torso/hands) for ticks after passing through high grass. And whole body after coming from the woods. The na…

And Lyme nephritis.
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