but think of the shareholders
It costs something like $0.50 cents a pill.
I think their point is that an available cure would allow the quarantine to end and re-start the economy.
Study: No evidence of efficacy of hydroxychloroquine in hospitalized patients
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Re: Study: No evidence of efficacy of hydroxychloroquine in hospitalized patients
#22Point is that the study is done at the wrong stage, too late.
That may be, but it's gonna be harder logistically to do a study commencing from onset of symptoms vs at moment of hospitalization.
There's also the fact that study makes it less likely that pre-hospitalization HCQ will have any effect either. Applying a Bayesian analysis here, it's now likelier that the true ground truth is simply that HCQ doesn't do anything to COVID-19 at all, not necessarily that it works only in a narrow early window. HCQ has severe side effects too, that require close monitoring and can be fatal. If it's not clearly doing good then it definitely shouldn't be being given to COVID-19 patients.
Personally, my hopes are more on remdesivir and favipiravir, both of which are actual antivirals (HCQ is not) and thus were always more promising. HCQ was never the most promising drug candidate, and the only reason we're even talking about it as much as we are is that, for whatever random reason, that's the one Trump heard about first and then fixated on.
Re: Study: No evidence of efficacy of hydroxychloroquine in hospitalized patients
#23Given that I need hydroxychloroquine to treat my rheumatoid arthritis, I'd like this hypothesis to be either proven or disproven as rapidly and as unambiguously as possible.
Re: Study: No evidence of efficacy of hydroxychloroquine in hospitalized patients
#24Point is that the study is done at the wrong stage, too late.
Point is far too much time and money has been wasted chasing this particular goose just because your cult leader saw it as the silver bullet that could save his re-election. I hope we don’t waste additional bandwidth in the medical community just to disprove additional no-true-Scotsmen rewritings of history. Just this comment section already features two of them: “too late”, and “only in combination with zinc”.
I don't think we wasted too much time and money on chloroquine. It looked promising in early trials. The proper thing to do is follow up on that. If it helped even just a little it would save literally thousands of lives. Having a well known drug be even slightly effective is pretty close to the best case scenario. Not following up on such leads would be stupid.
Re: Study: No evidence of efficacy of hydroxychloroquine in hospitalized patients
#25Totally out of my depth here. I've been following Dr. Chris Martenson's daily covid-19 updates since late January. He is adamant this treatment is only effective in combination with zinc supplements.
So why doesn't this guy setup clinical trials instead of providing non-confirmed medical advice on the daily? Probably cause he is lazy and more interested in selling and promoting himself than he is actually solving problems. This guy knows the scientific method, I assume. he knows that something needs to be observable and replicated. Instead, he is asking us to trust his brilliance on something where the side effec…
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Re: Study: No evidence of efficacy of hydroxychloroquine in hospitalized patients
#26It was observed that between 7% and 28% of hospitalized have acute myocardial injury [1-4]. When one looks at Epocrates (database for drugs which is why I'm not linking anything here) the severe adverse reactions of hydroxycholoroquine include QT prolongation, cardiomyopathy, and torsade de pointes. Just to define some things here, QT prolongation is the time from your Q wave to your T wave, or the start of an electr…
> between 7% and 28% of hospitalized have acute myocardial injury
So, for a younger (< 60) otherwise healthy person whose chance of death with covid is less than 1%, it would seem ill advised to take this medication at the onset of symptoms, unless the the disease itself causes similar or higher rates of heart damage.
Re: Study: No evidence of efficacy of hydroxychloroquine in hospitalized patients
#27Lots of conflicting research happening[1], until we get multiple controlled trials we won't really know. Here's one that shows improvements.
[1] French ~50 patient study that tried Control, Hydroxychloroquine, and Hydroxychloroquine + Azithromycin combo: https://www.mediterranee-infection.com/hydroxychloroquine-an...
Re: Study: No evidence of efficacy of hydroxychloroquine in hospitalized patients
#28Totally out of my depth here. I've been following Dr. Chris Martenson's daily covid-19 updates since late January. He is adamant this treatment is only effective in combination with zinc supplements.
Who is Dr. Chris Martenson and which hospital does he work at? He seems to be suffering a name collision with some economics PhD guy who appears on Fox.
Savage.
Re: Study: No evidence of efficacy of hydroxychloroquine in hospitalized patients
#29Given that I need hydroxychloroquine to treat my rheumatoid arthritis, I'd like this hypothesis to be either proven or disproven as rapidly and as unambiguously as possible.
Because HCQ’s efficacy was briefly endorsed by a controversial political figure I fear that there’s no evidence in either direction will convince the true believers. This is now a political issue, like global warming. Hopefully someone is ramping up production so availability improves for those that actually need it.
Re: Study: No evidence of efficacy of hydroxychloroquine in hospitalized patients
#30This trial wasn't randomized, but a quasi randomized trial for HCQ whose preprint was leaked is here:https://www.dropbox.com/s/8b2govfsa6n0xbq/NEJM_Clinical%20Ou...
Study indicates that one adverse effect of HCQ (on top of not improving patient outcomes) is increased ventilator times.