191–200 of 324 posts
Me and my girlfriend are microdosing LSD for the past couple of weeks. We both are very outgoing persons, but due to Corona, our life is really boring which makes our mental state not as positive as it was. We notice that we have more acceptance to the Corona situation. Especially the “bad” days, the microdosis makes the day much more acceptable.. I’m aware that this is a very brief explanation. If you are very inter…
When you say microdosing, what size doses are you using?
I have a friend who has experienced magic mushrooms recreationally about half a dozen times in her 20s. After each trip she reported feeling clear headed and more mindful - she described it as though her mind's harddrive had been defragmented. Fast forward 10 years and that same friend felt low during lockdown over the past 12 months. After reading up online she decided to try microdosing mushrooms rather than the ma…
I have zero experience with drugs, so I am wondering if there is a sugar/cigarette industry that put a lot of money into promoting it's products, then what will be different when drugs get legalized? Won't we repeat the history where companies make billions from this products, put them into ads to spread the use and addict people, suppress research into bad side effects etc,. Personally I think there are some good ap…
I was not able to speak to my father, let alone staying in the same room were he was, for about 26 years (~18yr old till recently ~44yr). The background for this was my choice of leaving an ultra orthodox jewish community and going on my own. I recently tried that (after 3 years of hesitation) and the magic happened. It affected my structure of feelings in several ways indeed, but in the context of this one, I would…
What's your take on allowing a substance to change you so much?
For those curious: you can cultivate your own at home. It’s 100% legal to purchase psilocybin spores online in many states. I just had to throw out a grow due to contamination - super frustrating setback - but I’m determined to produce a healthy harvest.
Before anyone rushes to do this: Cultivating these mushrooms is not legal, even if buying the spores might be. Likewise, self-medicating severe depression with hone grown psychedelics is not a great idea. These studies use controlled administration in supervised environments often with therapy as part of the process. You cannot replicate that at home. Psychedelics also can’t be dosed continuously like traditional ant…
Earlier quoted context omitted.
What's your take on allowing a substance to change you so much?
Can’t speak for OP but it sounds preferable to when he “allowed” his relationship with his father to take him on such an emotional journey.
One cannot speak indeed until one tries.
Earlier quoted context omitted.
I know a lot of people whose minds were ruined by psychedelics. It’s something you will see when you spend time in those communities. It doesn’t happen to everyone, but it’s common.
This is why research is needed. My gut feeling is that the root cause is overdosing. Just search "How often can I do shrooms" on Quora and you get the gamut from "1 or 2 times per year", to "microdosing everyday, macrodose every weekend, and hero dose every month".
I used to macrodose and get immensely creative over a week or so. With a happy outlook on nature and all things uncontrollable around me.
But then the high died some day. Lethargy came back. Lack of actual structure and the 'happy go lucky' attitude derailed whatever tied my past with plans for the future.
Microdosing seemed to help from time to time, but mostly I just get distracted with random consumption instead of planned, structured and thought through creation.
I was not able to speak to my father, let alone staying in the same room were he was, for about 26 years (~18yr old till recently ~44yr). The background for this was my choice of leaving an ultra orthodox jewish community and going on my own. I recently tried that (after 3 years of hesitation) and the magic happened. It affected my structure of feelings in several ways indeed, but in the context of this one, I would…
The study was just published in the most prestigious medical journal in the world [1]. Whatever you think of the study, this is rather significant. If you told me even 2 years ago there would be a randomised trial of magic mushrooms in NEJM, I would not have believed it for even a second. One point not to miss is that they screened 1000 patients to come up with the study population of 59. Nevertheless, I consider the…
I'd be curious how many 10,000s if not 100,000s of people pharmaceutical companies go through, along with changing/crafting their selection criteria to keep out people/symptoms they know have more/strong "side"/harmful effects with, until they get acceptable looking results; propaganda using truth - "Misleading with true fact" - https://www.youtube.com/watch?v=lls_2tfWcUI
The study was just published in the most prestigious medical journal in the world [1]. Whatever you think of the study, this is rather significant. If you told me even 2 years ago there would be a randomised trial of magic mushrooms in NEJM, I would not have believed it for even a second. One point not to miss is that they screened 1000 patients to come up with the study population of 59. Nevertheless, I consider the…
Note that while not ideal this is completely normal for any early stage drug trial. Most drugs get licenced based on data in which the trials would have excluded 90%+ of the typical clinical population. This is certainly true in depression where most drug trials will exclude patients with comorbid MH conditions, and often exclude them for "too many previous episodes". But it's also true in physical health (e.g. asthma).
I'm sure it's even harder when recruiting for an RCT in psychedelics though. A friend was working on clinical applications of MDMA about 15 years ago and a stipulation of the ethics board was that her participants had to have taken MDMA at least 3 times before, but not more than 10 times. Not easy to recruit for that study!