181–190 of 303 posts
I'm sort of surprised they didn't extract/synthesize psilocybin directly and administer that. Decades ago, I grew a few batches of P. Cubensis. Even amongst mushrooms from the same rice cake, the dosage wildly varies. You could have a "trip" from a tiny mushroom or eat a handful of duds.
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Can confirm, especially mushrooms. I had one trip on them and what my main take away was: It's exhausting to trip on mushrooms and after 4-5 hours I wanted to be sober again. I'll probably do it again in a few month but for me it's a whole-weekend kind of deal and hardly a party drug
my main issue with mushrooms is how nauseous i get -- also, i lose all my appetite for at least 12h (last time, it took 24h for me to be actually hungry again).
Considering micro-dosing either helps you or at worst it has no bad effects I don't see why you wouldn't try it if you had access to it and the legal aspect didn't hinder you. Personally and subjectively it did help me, I wasn't depressed but it did help with creativity and learning, I gained like 150-200 points on chess.com just from playing and reviewing games (rarely)
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I'm not saying her experience is invalid. If it works for her, great. But there is this tendency of microdosing proponents to oversell what is effectively a high(nothing wrong with that, I love getting high) as some sort of profound self-help tool. It's a high. That's fine. Getting high can have positive effects too. Call it that, though.
The paper stated James Fadiman as the source for the characterization of a microdose, it however failed to properly convey his point of view. I've heard James Fadiman reporting twice that it is 10% of a recreational (1-3g) or therapeutic dose (3.0-3.5g), but certainly not 10% of a heroic dose. This study went with 0.5g which is 10% of what's considered a heroic dose. The effective dose is considered to be 6mg if psil…
During my youth, I had strong trips with .5g and meh one's with a few grams, sure it's not the norm but it's not an exceptional occurrence either.
My experience told me that the stem of the smallest mushrooms are a lot stronger than those of the bigger one but that an heuristic not an hard rule.
If I wanted to microdose psilocin (for which psylocibin is a prodrug), I would order 4-AcO-DMT¹ fumarate (another prodrug for psilocin) from a reputable Canadian chemical supplier. It's almost identical to mushrooms, the difference being that it is predictable and somewhat easier on the digestive system.
1) https://en.wikipedia.org/wiki/O-Acetylpsilocin https://psychonautwiki.org/wiki/4-AcO-DMT
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Have you tried Kratom? I'm by no means recommending it, just curious if you've tried it to combat depression.
As a daily Kratom user, I would not recommend using Kratom for something like depression. You're treating the symptomps at best while cultivating addiction.
> microdosing > half a gram doses of cubes. I don't think the studies designers really thought this one through.
Microdosing is great but not for everyone. It can actually increase your anxiety if you take too high a dose. Personally, I take a micro dose of LSD every other Friday, drink a cup of coffee and hit the gym. It does wonders. And definitely not addicting.
You're lucky you can repeatedly trust your source, and their measuring skills. /jealous.
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> Been doing it for some months on & off, this shit is legit The linked study seems to contradict you: >> According to our findings, low doses of psilocybin mushrooms can result in noticeable subjective effects and altered EEG rhythms, but without evidence to support enhanced well-being, creativity and cognitive function. We conclude that expectation underlies at least some of the anecdotal benefits attributed to mic…
Lack of strong evidence is not strong evidence of lack. Subtle effects like "well-being, creativity, and cognitive function" can be quite hard to track, and there are confounders galore.
That’s the key point. This person expects it to work so it works. They’re not adding it to their Morning Productivity Hacks Routine because they think it doesn’t work.
I think this is saying that microdosing is mainly placebo effect, and otherwise doesn’t do much. This makes sense. All these participants took full dose psychedelics at some point, and thus had very strong associations.
So far, as far as I know, that seems to be the prevailing scientific opinion, i.e. microdosing seems to be about as effective as placebo (at least microdosing of psilocybin).
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>This, to me. means that a microdose is a gamble not worth taking. This has always been the problem with psychedelics as a therapeutic approach. It's hard to reconcile being a responsible clinician and recommending a therapy with such mixed and often-negative results. They are in charge of a person's mental well-being in a way that people evangelizing psychedelic therapy don't seem to properly appreciate. If a patien…
As far as I know experiments of CBT + psychedelics have shown very promising results for treating PTSD and certain kinds of depression, specially in people that are about to die and need to come to terms with that. These are not microdosing experiments though. The usual way it is handled is that you get a few weeks of CBT then you get half a dose and the following week you get a full dose followed by more weeks of CB…
From what I recall, a low dose of methylphenidate is used as a control in many studies because it has some of the same side effects without the trip. For psychedelic-naive people who don’t really know what to expect, I could see it being an ok control. Once you’ve experienced a single high-dose trip though… yeah… you’re never going to trick someone with it.