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Reversing hearing loss with regenerative therapy

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Re: Reversing hearing loss with regenerative therapy

#181

Post by jacquesm »

bashinator wrote: post #92
dazc wrote: post #61

Earlier quoted context omitted.

I had odd bouts of tinitus as a teenager, like you, no obvious causes. It went away and came back with a vengence about 15 years ago. That lasted a year or so but over time it's become more of a minor irritation than a major handicap. I guess, my brain has trained itself to deal with it? The only tip I can give you is to always have some kind of background sound that you can focus on rather than the buzzing in your o…

I had pretty severe tinnitus. Getting religious about earplug usage at music performances plus getting musician-specific hearing protection pretty well put it into remission. Cymbals with no earplugs are specifically the worst.

Cymbals (and plastic foils being crumpled) can be crazy loud and if you are a drummer you really should wear ear protection.

Re: Reversing hearing loss with regenerative therapy

#182

Post by hackernewds »

biggieshellz wrote: post #146
rhubarbcustard wrote: post #144

Earlier quoted context omitted.

Thanks for sharing that, its got some amazingly deep articles on audiology. It's really hard though, to find out what Crescendo actually is and how to buy it!

I think you need to email David McClain to buy a compiled version, but the source (not including the plugin wrappers, etc.) is here: https://github.com/dbmcclain/Crescendo-Hearing-Correction

I'm having a hard time understanding what this is still. Is it an equalizer?

Re: Reversing hearing loss with regenerative therapy

#183

Post by Terry_Roll »

lr4444lr wrote: post #79
samstave wrote: post #54

Earlier quoted context omitted.

I have increasing;y bad tinnitus. Will this help with that? I hear a permanent and constant low-volume very high pitch "squeal" in my ears at all times, I was never a big loud music listener, and I have always brought ear-plugs to loud events - and have had no big ear-rupturing moments (such as a gun firing close to my head without protection etc...

That is an open question. Tinnitus is NOT well understood. It does have fairly high correlation with SNHL, which IS pretty well understood as a matter of cochlear hair cell destruction. So there is a lot of optimism that if we can treat the latter, the former will go away, but there may be other components to it in the central nervous system. It certainly would only help to fix SNHL in trying to treat tinnitus.

True, talking to a hearing specialist, they didnt know histidine can reduce hearing loss, now whether this is due to histidine being a precursor for histamine which can help white blood cells move through tissue, or because it can play its part in remyelinating nerves isnt clear.

Manganese could also play a part because its the most abundant metal in hair samples which might translate to the hairs in the ear. However to get it there, you'll need to increase your cysteine intake, but we dont absorb it easily through the gut so we have to use N Acetyl Cysteine...

SO many chemical variables....

Re: Reversing hearing loss with regenerative therapy

#184

Post by Terry_Roll »

jus101 wrote: post #158
samstave wrote: post #105

Earlier quoted context omitted.

I'm pretty sure you are spot on with Sodium: I do eat a lot of sodium, but here is an interesting anecdote: A friend's husband had Lyme Disease - and had very bad veritgo from it which was exacerbated by a high sodium intake (I assume the ear works on the sodium potassium pump in some manner?) but she used to have to make a very careful diet for him so as to remove sodium as much as possible, which would prevent his…

The vertigo could be due to Ménière‘s disease. I had it for a year or so in my 20s - reducing salty snacks sorted it out. https://en.m.wikipedia.org/wiki/Ménière%27s_disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655085/

"Where an inflammatory component is suspected in bilateral Ménière’s disease, short courses of systemic glucocorticoids may be appropriate. It recently has been shown that glucocorticoids not only influence inflammatory process in Ménière’s disease, but also alter fluid dynamics via an interaction with the sodium pumps in the semicircular canals (Ponduglula et al 2004). Intra-tympanic application of corticosteroids appears to have only temporary effects (Dodson 2004) and is probably not recommended"

Re: Reversing hearing loss with regenerative therapy

#185

Post by Klonoar »

hackernewds wrote: post #178
Klonoar wrote: post #124

Earlier quoted context omitted.

I’m doing something similar (for sleep apnea originally, but the crossover due to jaw needing to be forward is a thing). Highly recommend.

I've read there are mouth shapers that full your jaw forward that significantly helps with sleep apnea. but at the same time it kills your bite, and reforms your jaw. any recommendations? tangentially I also have tinnitus so now I'm wondering if it's related.

Hmmm, I've not heard anything re: bite killing. It's definitely had points where it affected my ability to chew due to things shifting, but that's been easily countered each time by my Ortho just shaving down or adjusting the appliance - it's been due to my bite putting more pressure on the left or right row as I adjust. Other than that, over ~6 months so far I haven't really had much to note. I just wear it while sleeping and periodically while coding (since I'm not needing to talk during that... it's like "free time" for it to work) and it "just works".

Quality of sleep is through the roof, I'd forgotten what good sleep is like. If I miss a night of sleep with it (e.g, I travel and forgot to bring it with me) I absolutely feel it the next day.

Tinnitus-wise, I noticed that it got worse at first but then settled and is actually more in the background than it used to be. FWIW, I've had tinnitus for as long as I can remember, so I'd consider myself ~90% habituated to it - it doesn't bother me outside of any concern of it getting worse. I think this has made it easier for me to objectively judge whether something is helping or not - if my tinnitus is never cured, but never gets worse, I'll be fine.

https://vivos.com is what my Ortho got me on. I can't speak to others, but this has worked well for me so far.

Re: Reversing hearing loss with regenerative therapy

#186

Post by ddingus »

wrycoder wrote: post #152
ddingus wrote: post #112

Earlier quoted context omitted.

Another thing they could try would be a different eq curve overall. I always find The Sound of Music as reproduced on older narrow band with am radios and phonographs interesting. A lot of that gear doesn't really produce anything over 10 khz. But, where they emphasized frequencies in the spectrum is different from Modern equipment, which basically is shooting for flat response. My grandfather's old radio, when playe…

I think one of the reasons for vinyl’s reputation is that it’s often played on old sound systems. Ones with real bass and treble controls!

Yeah I think that is true. However I was really speaking to something a little older than that, though vinyl could still be a source signal for it.

You go back far enough, and the gear starts to roll off about 10 khz, yet if you listen to a modern signal through it, it sounds good. That's what I'm getting at.

Re: Reversing hearing loss with regenerative therapy

#188

Post by encoderer »

_xlrm wrote: post #162
encoderer wrote: post #67

What the heck is going on with tinnitus? https://trends.google.com/trends/explore?date=all&geo=US&q=%... I’ve been afflicted with tinnitus after a mild covid case in January and now that I’m looking it seems like this is a growing problem. So many comments here about tinnitus.

* Trigger warning * Texas Roadhouse CEO developed severe tinnitus after having COVID and took his own life because of it [0] [0] https://amp.courier-journal.com/amp/4759047001

I read this shortly after I got tinnitus and it did not help my mental health. I immediately wished I never saw it. I would probably delete this, it’s not out of line but it might save somebody a lot of negative thoughts and fear.

Re: Reversing hearing loss with regenerative therapy

#189

Post by lamename »

crackedbassoon wrote: post #165
gumby wrote: post #108

Earlier quoted context omitted.

One sobering lesson from my time working in the life sciences is that everything is insanely complex and once you've isolated everything in your problem space into a small, relatively isolated set, you still end up with an insanely complex space. Essentially it's fractally complex.

Except it is actually quite easy to measure hearing thresholds in nonhumans as well as human babies via auditory brain responses (ABRs).

You are right, but so is the grandparent. A noise, click, or tone-based ABR is very basic in terms of measuring restoration of natural hearing. There are issues of rich spectrotempral aspects of speech, music, and natural sounds that (ideally) would be accounted for. Along with amplification and gain control, to which Outer Hair Cells are a major contributor in the cochlea.

There are various ways to measure these thing in animals and humans physiologically (ABRs, otoacoustic emissions, invasive and noninvasive electrophysiology), and with careful psychophysical experiments. None are perfect or comprehensive. Each method has its own strengths and weaknesses.

But it is indeed more complex than just testing a basic audibility threshold. The same issues come up with audigorams for hearing aid calibration and hearing in noise.

Re: Reversing hearing loss with regenerative therapy

#190

Post by biggieshellz »

hackernewds wrote: post #182
biggieshellz wrote: post #146

Earlier quoted context omitted.

I think you need to email David McClain to buy a compiled version, but the source (not including the plugin wrappers, etc.) is here: https://github.com/dbmcclain/Crescendo-Hearing-Correction

I'm having a hard time understanding what this is still. Is it an equalizer?

It is a multi-band nonlinear compressor. It deals with each band of hearing (https://en.wikipedia.org/wiki/Bark_scale) individually. In each band, it elevates soft sounds to just past the threshold of audibility with someone's impaired hearing, to make it sound like the softest sound they can hear. And it elevates medium sounds a little bit less, to make it sound like a medium sound. And it elevates loud sounds not much at all. Hence the nonlinearity.
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