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In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

nature.com

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Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

#181

Post by makruiten »

James_Henry wrote: post #100
scottlocklin wrote: post #6

1) DHEA is not a diabetes med. In fact it's a steroid (not really an anabolic one, though it is a precursor to anabolics) and illegal in the EU. It is a substance which is lowered in older people, so older people supplement with it. 2) Metformin is a diabetes med, and it's used by antiaging enthusiasts independently and along with growth hormone 3) Fasting creates larger growth hormone spikes, and improves sugar clea…

Fasting does increase growth hormone amount and spike frequency, but it also makes you growth hormone resistant https://www.sciencedirect.com/science/article/pii/S155041310... Why is it lousy to do formal research on "stacks" people have been using for years?

This seems to be the case for longer fasts and for starvation. I wonder if it also applies to time restricted feeding without calorie restrictions.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

#182

Post by AnIdiotOnTheNet »

qnsi wrote: post #172
AnIdiotOnTheNet wrote: post #164

Earlier quoted context omitted.

> I’ve been doing it for about a year and a half, just skipping breakfast each day and lunch one or two workdays a week. You call that a fast? As someone who's lost and kept off about half their body weight, I feel qualified to tell you that skipping a meal here and there is not fasting. In fact, if you're eating every day you're not fasting. Fuck, I mean, I only eat about 1.5 meals a day as a requirement of merely m…

this is just different definition of what fasting is. What he's doing is time-restricted eating but it is a form of fasting. You are just doing longer fasts. No need to gatekeep

So is it a fast just whenever you're not eating?

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

#183

Post by qnsi »

AnIdiotOnTheNet wrote: post #182
qnsi wrote: post #172

Earlier quoted context omitted.

this is just different definition of what fasting is. What he's doing is time-restricted eating but it is a form of fasting. You are just doing longer fasts. No need to gatekeep

So is it a fast just whenever you're not eating?

technicly fast is defined as not eating.

"Intermittent fasting means different things to different people, even among the research community. This lack of specificity has been a source of consternation for experts in the field of fasting, with some advocating that the phrase be retired. Often, when someone uses this phrase they may actually mean one of the following:

Time-restricted eating Alternate-day fasting Periodic or prolonged fasting (multi-day) - less frequently referred to as intermittent"

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

#184

Post by qnsi »

Tringi wrote: post #180
qnsi wrote: post #174

Earlier quoted context omitted.

Should be here but can't get it on sci-hub Fahy, G. M. et al. Aging Cell https://doi.org/10.1111/acel.13028 (2019).

I'm searching for it too, and I can't find the actual text. Somebody doesn't want us to begin mixing that cocktail ourselves :D

I don't think it's published yet. Should in the recent tab on this site I think https://onlinelibrary.wiley.com/journal/14749726

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

#187

Post by Camisade »

Tringi wrote: post #180
qnsi wrote: post #174

Earlier quoted context omitted.

Should be here but can't get it on sci-hub Fahy, G. M. et al. Aging Cell https://doi.org/10.1111/acel.13028 (2019).

I'm searching for it too, and I can't find the actual text. Somebody doesn't want us to begin mixing that cocktail ourselves :D

When I first saw that article, I swear it contained a link to the associated paper in Aging Cell. Now when I go to the Nature.com article, that link is no longer there.

How many people are currently thinking, "All three drugs/compounds are pretty well understood, and reasonably benign when administered under a Doctor's supervision with periodic blood testing; in the absence of specificity, let's just start with fairly standard daily prescription doses and see what happens..."

As someone afflicted by 'chronic aging' (at the rate of one year, per year), I'm hugely fascinated by prospective "cures." ;-)

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

#188

Post by phaedrus11 »

qnsi wrote: post #174
ThinkBeforeDo wrote: post #105

Where's a link to the actual paper/ peer-reviewed publication?

Should be here but can't get it on sci-hub Fahy, G. M. et al. Aging Cell https://doi.org/10.1111/acel.13028 (2019).

https://www.gwern.net/docs/longevity/2019-fahy.pdf

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

#189

Post by tomubl »

badestrand wrote: post #153
jvagner wrote: post #96

Earlier quoted context omitted.

The idea of fasting and the reality of fasting are different. The idea is more painful than a committed effort. Once you accept and embrace the fast, it’s freeing. Like running every day.... once you know you’re going to do it, the resistance withers.

After doing intermittant fasting for half a year I think you shouldn't generalize too much from your own experience. Yes, it gets easier but it stays painful and requires a lot of willpower ime.

I IF but I can workout before my 11 to 5 eat window. It eliminates hunger. I time it when I am done exercising i drink a 64 ounce smoothie that i concoct with targeted nutrients.

Fasting increases vasointestinal peptide VIP which boost growth hormone.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’

#190

Post by xiphias2 »

gwern wrote: post #185
ThinkBeforeDo wrote: post #105

Where's a link to the actual paper/ peer-reviewed publication?

It's finally available: https://www.gwern.net/docs/longevity/2019-fahy.pdf

Thanks! How did you get it? Were you part of the research?

It's interesting to me how important the results are and how underreported this research is at the same time.

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