I'm very excited about this; I'm not in a position right now where I particularly need a laptop, but my existing laptop is very much EOL at this point, to the point where some components have started failing, and depending on reviews I strongly suspect that when I need a new laptop the Framework 16 will be it.
The biggest feature I want is a good stylus/touchscreen for portable drawing, in my dream world that would be something I could swap in and out, possibly replacing the keyboard. I can imagine having the front keyboard mostly be a touchscreen display and just sticking a narrow module to one side of the screen with hotkeys...
Having a decent laptop that I can add a GPU to and take a GPU off of, add a digitizer and use as a drawing tablet or remove a touchscreen for trips where I don't need one, switch keyboards for specific projects -- quick swapping of components isn't just cool from a repair perspective, it's a major selling point to be able to have a single device that can serve multiple roles on demand. In most cases you probably don't want a GPU on a laptop; you want extra battery life. Until you do. And when you have some rendering workload or something intensive to do, you turn off the computer, plug in the GPU, and turn it back on.
I really hope that 3rd-party components take off. I'm trying to be responsible and wait until I have an actual need (and at the very least I want to wait and see reviews), but I'd be very tempted to buy one of these as soon as they launch if there was digitizer support, there aren't a lot of good, repairable, linux-compatible drawing tablets on the market.