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Ibuprofen alters human testicular physiology

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Re: Ibuprofen alters human testicular physiology

#171

Post by jcranberry »

function_seven wrote: post #165
3pt14159 wrote: post #133

Earlier quoted context omitted.

Yes. Let me rephrase what you phrased: Imagine you're investigating a drug for hair loss, like 20000 other researchers hellbent on achieving their goals. You gather a group of 31 bald white men. 15 of them take a placebo and 16 take the experimental drug for 24 weeks, but because your random allocation put more extra bald people in your non-control group you fixed it by balancing the two groups. Your counterpart that…

You had to introduce a lot of assumptions to invalidate the n=31. So let me lay it out in more detail. I recruited 31 white men who self-report having no hair on at least 500cm^2 of their head. They all had hair as adolescents, and lost it gradually throughout their 20s or early 30s. They're all at least 37 now. I then sort them into the two groups by assigning sequential IDs in random order. Those with an odd ID are…

Ah, but you did not precisely define the area in cm^2 of hair which constitutes a full head of hair vs bald!???!?

Clearly this is a sham and you needed at least 31^47 participants in this study you charlatan!

Re: Ibuprofen alters human testicular physiology

#172

Post by driverdan »

orasis wrote: post #72
fencepost wrote: post #13

Okay, so ibuprofen impacts testicular function, acetaminophen/paracetamol causes muting of emotional response (along with the liver toxicity), many other painkillers are related to ibuprofen, and opiates are Right Out. Is aspirin at least reasonably safe as long as the blood thinning isn't a problem?

Turmeric is my pain killer of choice.

Turmeric is not a pain killer.

Re: Ibuprofen alters human testicular physiology

#173

Post by randallsquared »

rconti wrote: post #109
koolba wrote: post #71

Earlier quoted context omitted.

Is the /d per day? If so that's well within what I've seen "normal" people take. A regular Advil is 200mg. The usual dose is two pills, so 400mg. If your larger it's common to take three or four pills. Multiply by a dose ever six hours and it's quite easy to get to 3200mg per day.

Yup; after seeing my mom be recommended 3-4 pills every 6 hours as needed for knee pain, I sure don't bother with just 2 pills as a 200# male if I "need" ibuprofen. I either take 3, or I take nothing. Fortunately I have no chronic issues, rarely need ibuprofen (in fact I'm paranoid about taking it for muscle aches as I've always felt it must harm muscle development, which seems to be catching traction as a theory), a…

TIL that my pain is weak and mild, even when I think I'm in a lot of pain. I'm well over 200 lbs (still), but 200mg of ibuprofen usually eradicates whatever pain I have. If it's really bad pain, then I take 400mg.

Re: Ibuprofen alters human testicular physiology

#174

Post by grzm »

driverdan wrote: post #172
orasis wrote: post #72

Earlier quoted context omitted.

Turmeric is my pain killer of choice.

Turmeric is not a pain killer.

I haven't heard that, either. I have heard that it has anti-inflammatory properties, which could indirectly reduce pain that arises from inflammation, such as arthritis. Here's one article describing it.

http://content.time.com/time/health/article/0,8599,1910028,0...

Your comment is quite brief (as is the one you're responding to, for that matter). Is there something in particular you have in mind?

Re: Ibuprofen alters human testicular physiology

#175

Post by Dylan16807 »

kinkrtyavimoodh wrote: post #18
MollyR wrote: post #3

It would be mind boggling if pain killers were connected to dropping male fertility. It might even explain why so many cultures had rites to male adulthood involving extreme pain.

I sometimes imagine, with horror, what would happen if after 500 years of progress, humanity were to realize that almost all cultural practices they painfully, one by one, undid, were all sensible to begin with for reasons that humanity didn't previously understand.

Tiny positive effects are not worth the downsides of most of those. So even if that's somehow true it's okay.

Re: Ibuprofen alters human testicular physiology

#176

Post by edwhitesell »

jdeibele wrote: post #96
sliverstorm wrote: post #63

Earlier quoted context omitted.

Have you tried dropping the dose and interleaving with acetomenophin? I have been hearing recently that's an increasingly popular strategy, sharing the load between the kidneys and liver.

Because they work in different ways, that's what I'm fond of doing for myself and my children. Start with ibuprofen, then try a table of acetaminophen a couple of hours later. If it's a really bad headache, start with one of each.

Our pediatrician recommended this when treating a fever. Alternate Tylenol and Motrin, then you can dose every 3 hours instead of every 4.

Re: Ibuprofen alters human testicular physiology

#177

Post by 3131s »

dominotw wrote: post #74
Romanulus wrote: post #73

Earlier quoted context omitted.

Nietzsche would advise against all forms of painkillers.

why is that?

For sports injuries and the like I avoid pain killers because I want to get as much feedback as possible from my body about how the injury is healing.

Re: Ibuprofen alters human testicular physiology

#178

Post by dpark »

TylerE wrote: post #129
rincebrain wrote: post #108

Earlier quoted context omitted.

Naproxen is OTC in the US, as Aleve, but you need a prescription for higher doses, like with ibuprofen.

That sort of logic has never made sense to me. It's as if the regulators think people would never take more than one at a time.

The regulators think, quite correctly, that people will generally take the dose on the bottle. If you only allow sales of Ibuprofen in 200mg pills and the bottle says “take two”, that’s what the vast majority of the public will do. If you allow sales of “ultra strength” 2000mg pills, a decent chunk of the population will take 2-4 grams because “ultra” must be better.

Re: Ibuprofen alters human testicular physiology

#179

Post by function_seven »

jcranberry wrote: post #171
function_seven wrote: post #165

Earlier quoted context omitted.

You had to introduce a lot of assumptions to invalidate the n=31. So let me lay it out in more detail. I recruited 31 white men who self-report having no hair on at least 500cm^2 of their head. They all had hair as adolescents, and lost it gradually throughout their 20s or early 30s. They're all at least 37 now. I then sort them into the two groups by assigning sequential IDs in random order. Those with an odd ID are…

Ah, but you did not precisely define the area in cm^2 of hair which constitutes a full head of hair vs bald!???!? Clearly this is a sham and you needed at least 31^47 participants in this study you charlatan!

Shit. I just rechecked my data, and it appears the "full-head-of-hair" group still had 482cm² of shiny scalp. I need to fire my measurement tech and issue a recall...

Re: Ibuprofen alters human testicular physiology

#180

Post by Retra »

kinkrtyavimoodh wrote: post #18
MollyR wrote: post #3

It would be mind boggling if pain killers were connected to dropping male fertility. It might even explain why so many cultures had rites to male adulthood involving extreme pain.

I sometimes imagine, with horror, what would happen if after 500 years of progress, humanity were to realize that almost all cultural practices they painfully, one by one, undid, were all sensible to begin with for reasons that humanity didn't previously understand.

You're just describing evolution. We almost assuredly don't practice most of the habits of whatever sludge we evolved from, regardless of how useful it is to sludge to continue such practices. And if we stop doing things, we will probably do so for reasons just as valid as why our ancestors started them.
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