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FDA Approves First Oral Treatment for Postpartum Depression

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Re: FDA Approves First Oral Treatment for Postpartum Depression

#161

Post by warbeforepeace »

haldujai wrote: post #156
afavour wrote: post #153

Earlier quoted context omitted.

> I'll never understand why there's such a dominance of luddite thinking, bad takes and conspiracy theories on HN, when it comes to the topic of mental health I imagine there are many professional forums filled with people who know topic X inside out therefore assume they must also be an authority on unrelated topics Y and Z. But I also suspect there’s something about software engineering, perhaps the ability to succ…

It's insane to me that a group of educated and seemingly intelligent people seem to think they understand more about drug safety and prescribing than the FDA, researchers and physicians. This is reminiscent of the Texas district judge who decided to controversially overrule the FDA on a medication safety decision that recently made the news, not good company one wants to have and I'm hoping is coincidental than sugge…

Its easy to figure out. Religion causes it.

Re: FDA Approves First Oral Treatment for Postpartum Depression

#162

Post by Traubenfuchs »

Does a positive allosteric modulator of the GABAa receptor cause addiction the same way any old GABA agonist does?

I love GABA agonists from benzos, benzo likes to phenibut and really wonder how it feels. If it feels the same way, then it feels like being wrapped in comfortable cotton, with all worries gone -heaven on earth. Hence the extreme addiction risk.

Re: FDA Approves First Oral Treatment for Postpartum Depression

#163

Post by NoZebra120vClip »

haldujai wrote: post #156
afavour wrote: post #153

Earlier quoted context omitted.

> I'll never understand why there's such a dominance of luddite thinking, bad takes and conspiracy theories on HN, when it comes to the topic of mental health I imagine there are many professional forums filled with people who know topic X inside out therefore assume they must also be an authority on unrelated topics Y and Z. But I also suspect there’s something about software engineering, perhaps the ability to succ…

It's insane to me that a group of educated and seemingly intelligent people seem to think they understand more about drug safety and prescribing than the FDA, researchers and physicians. This is reminiscent of the Texas district judge who decided to controversially overrule the FDA on a medication safety decision that recently made the news, not good company one wants to have and I'm hoping is coincidental than sugge…

[flagged]

Re: FDA Approves First Oral Treatment for Postpartum Depression

#164

Post by haldujai »

khazhoux wrote: post #160
lettergram wrote: post #157

Earlier quoted context omitted.

It is / was common enough for women to have their placentas ground up and consumed via a pill. It is supposed to help regulate the hormones I can imagine something like this doing something similar.

Common? Citation (and barfbag) needed!

It's shockingly true. I don't think any solid numbers are available on how common it is, but it at least appears to be relatively common in out of hospital births (and is becoming a trend).

> This relatively modern phenomenon is practiced predominantly by white, middle class, married women in the global North, and has grown rapidly since the 1970s

> Whilst prevalence is difficult to estimate, placentophagy is known to be practiced in North America, Oceania and Europe, plus parts of Latin America, the Middle East and Asia and is apparently growing in popularity. In a 2018 study of a medical records dataset for births outside of hospitals containing 23,242 birth events in the United States, 30.8% of mothers consumed their placenta. From 2009 to 2015 Google searches for “placenta encapsulation” increased 100-fold.

https://bmcpregnancychildbirth.biomedcentral.com/articles/10...

Re: FDA Approves First Oral Treatment for Postpartum Depression

#165

Post by zpeti »

mtlmtlmtlmtl wrote: post #150
xyzzy_plugh wrote: post #142

Since every top level comment here is a borderline tire fire, let me be the first to say: This is great news. We need better treatments for PPD, which is real and very serious that can cause long term lasting effects in serious cases without treatment, and can sadly even be fatal. Quality of life has risen steeply over the past several decades but mothers still walk an unpaved road. It's deeply worrying the lack of s…

Thank you. I'll never understand why there's such a dominance of luddite thinking, bad takes and conspiracy theories on HN, when it comes to the topic of mental health. Especially when it comes to drug treatments. Psychiatry no doubt has a lot of problems with it. But it's also the only game in town for a huge amount of people. What's the alternative? Prayer circles? Ayahuasca tourist traps? Cannabis? Homeopathy? Giv…

It’s very easy to explain. By going straight to medication you are treating the symptom not the cause. And you don’t even know if it works.

SSRIs don’t work for many people and we only found out 2-3 years ago.

Opioids were prescribed to half of America for back pain.

That gives scope for healthy scepticisms at least. Just because you might have some anecdotal evidence of some chemicals working, doesn’t mean it works for others or that it leads to a good place.

Lastly - there are clearly lifestyle and even moral choices that people make or don’t make that can lead to mental health issues. Just from a common sense perspective it seems much healthier to try and deal with these first, with therapy, than just medicating. And not just therapy. Exercise, diet. We know these affect mental health, yet pills are easy, and they make doctors money.

medicating is much easier than searching, finding and healing the cause. Therapy takes years, if not decades. I can understand why people pick the easier route, but easier is not always better. Also, are you just permanently going to be on pills then? I mean it’s a great subscription business, I can see that.

Re: FDA Approves First Oral Treatment for Postpartum Depression

#166

Post by warbeforepeace »

mtlmtlmtlmtl wrote: post #147
nemo44x wrote: post #15

> Use of Zurzuvae may cause suicidal thoughts and behavior. Zurzuvae may cause fetal harm. Might be better off just smoking a joint.

Cannabis can also cause fetal harm. And fetal harm is also irrelevant here because this is a treatment for postpartum depression, I.e depression after birth, at which point there is no fetus to be harmed. There's also no credible evidence that cannabis is an efficacious treatment for postpartum depression. But sure, why even bother with science? Just smoke a joint...

What is science and how can i get my neighbor with the trump flag in his yard to learn about it?

Re: FDA Approves First Oral Treatment for Postpartum Depression

#167

Post by haldujai »

lettergram wrote: post #157
xyzzy_plugh wrote: post #142

Since every top level comment here is a borderline tire fire, let me be the first to say: This is great news. We need better treatments for PPD, which is real and very serious that can cause long term lasting effects in serious cases without treatment, and can sadly even be fatal. Quality of life has risen steeply over the past several decades but mothers still walk an unpaved road. It's deeply worrying the lack of s…

It is / was common enough for women to have their placentas ground up and consumed via a pill. It is supposed to help regulate the hormones I can imagine something like this doing something similar.

It's claimed to but it's worth noting that supportive evidence doesn't exist, small albeit possibly underpowered RCTs suggests it does not and there are potential harms in doing so.

This review article provides an overview for the curious.

https://www.sciencedirect.com/science/article/pii/S000293781...

Re: FDA Approves First Oral Treatment for Postpartum Depression

#168

Post by aaronbrethorst »

I don't normally like to talk about matters this personal in a forum like this—especially given that I use my real name as my username here, but if it ends up helping one person then I think it'll be worth it.

My son was born a little over 9 months ago. He's healthy, delightful, and utterly normal—and yet I, his father, still ended up with postpartum depression. I think it's underreported and under-appreciated that fathers can also have serious postpartum mental health issues.

I've been taking Lexapro since January to manage the symptoms, predominantly anxiety, and feel great from it. I haven't experienced any noticeable side-effects that you might normally associate with SSRIs, and I'm incredibly grateful that I was in a position to start taking it.

New dads: if you feel unusually down, anxious, frustrated, angry, or depressed, consider talking to your PCP about treatment. Taking medication is not an admission of failure. Being a father is tough, but it shouldn't feel impossible.

edit: see my replies for exactly why I don't like discussing this.

Edit 2: since I’m concerned that some asshole in my replies might dissuade some folks who might seek care from seeking it, please check this article out: https://health.clevelandclinic.org/yes-postpartum-depression...

8-10% of new fathers experience postpartum depression.

Re: FDA Approves First Oral Treatment for Postpartum Depression

#169

Post by rs_rs_rs_rs_rs »

aaronbrethorst wrote: post #168

I don't normally like to talk about matters this personal in a forum like this—especially given that I use my real name as my username here, but if it ends up helping one person then I think it'll be worth it. My son was born a little over 9 months ago. He's healthy, delightful, and utterly normal—and yet I, his father, still ended up with postpartum depression. I think it's underreported and under-appreciated that f…

[flagged]

Re: FDA Approves First Oral Treatment for Postpartum Depression

#170

Post by aaronbrethorst »

rs_rs_rs_rs_rs wrote: post #169
aaronbrethorst wrote: post #168

I don't normally like to talk about matters this personal in a forum like this—especially given that I use my real name as my username here, but if it ends up helping one person then I think it'll be worth it. My son was born a little over 9 months ago. He's healthy, delightful, and utterly normal—and yet I, his father, still ended up with postpartum depression. I think it's underreported and under-appreciated that f…

[flagged]

With all due respect, fuck off. How dare you question my lived experience.
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