Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

FDA Approves First Oral Treatment for Postpartum Depression

fda.gov

Post reply on HN
Print view View original

151–160 of 299 posts

Re: FDA Approves First Oral Treatment for Postpartum Depression

#151

Post by touisteur »

standardUser wrote: post #85
linuxftw wrote: post #17

[flagged]

It sounds unethical to conduct human trials on babies when the mother could simply stop breastfeeding while taking the medication. I wonder if doctors recommend that for this or other drugs? I'd hope they inform the mother at the very least.

Stopping breastfeeding can also deepen depression and increase stress (talking from experience here) so it's really a difficult choice here, depending on the level of danger the mother is to herself.

Hopefully some data is compiled in the next years on the actual safety for infants.

Re: FDA Approves First Oral Treatment for Postpartum Depression

#152

Post by haldujai »

astrange wrote: post #148
haldujai wrote: post #136

Earlier quoted context omitted.

For drugs approved between 2011 and 2015 the FDA approval time was a median 303 days, faster than the EMA at 369 days.[1] For drugs approved between 2000 and 2010 (for all 3 agencies, the FDA gets more applications) the FDA approval time was a median of 268 days, faster than the EMA at 356 days and Health Canada at 366 days.[2] Based on your assertion and the data this means that you think all three of these agencies…

Here's an article from 2014 about how the EU has approved twice the sunscreens the US has: http://www.slate.com/articles/health_and_science/medical_exa... It's still true, we still don't have them. Obama even passed a law about it and it didn't help. > Based on your assertion and the data this means that you think all three of these agencies are harming the population, with the FDA being the lesser of all evils, by n…

Unless I'm missing something this is completely unrelated to and does not substantiate your argument that drug approvals are harming patients with the "mostly harming" argument implying more harm is being caused than prevented by current approval processes.

Once again, source?

> This is obviously true.

As you only mentioned the FDA, and keep only mentioning the FDA, it is not obviously true that you are arguing against all Western drug approval agencies and not specifically the FDA.

> Are Americans, Canadians and Europeans all different species?

All being the same species does not mean all have the same regulatory framework and in fact they don't. I am sorry but I really don't understand any of the points you're trying to make.

Re: FDA Approves First Oral Treatment for Postpartum Depression

#153

Post by afavour »

mtlmtlmtlmtl wrote: post #150
xyzzy_plugh wrote: post #142

Since every top level comment here is a borderline tire fire, let me be the first to say: This is great news. We need better treatments for PPD, which is real and very serious that can cause long term lasting effects in serious cases without treatment, and can sadly even be fatal. Quality of life has risen steeply over the past several decades but mothers still walk an unpaved road. It's deeply worrying the lack of s…

Thank you. I'll never understand why there's such a dominance of luddite thinking, bad takes and conspiracy theories on HN, when it comes to the topic of mental health. Especially when it comes to drug treatments. Psychiatry no doubt has a lot of problems with it. But it's also the only game in town for a huge amount of people. What's the alternative? Prayer circles? Ayahuasca tourist traps? Cannabis? Homeopathy? Giv…

> I'll never understand why there's such a dominance of luddite thinking, bad takes and conspiracy theories on HN, when it comes to the topic of mental health

I imagine there are many professional forums filled with people who know topic X inside out therefore assume they must also be an authority on unrelated topics Y and Z. But I also suspect there’s something about software engineering, perhaps the ability to succeed despite being deeply antisocial, or being very male dominated that means women’s mental health in particular is always going to be a dumpster fire discussion topic.

Re: FDA Approves First Oral Treatment for Postpartum Depression

#154

Post by astrange »

haldujai wrote: post #152
astrange wrote: post #148

Earlier quoted context omitted.

Here's an article from 2014 about how the EU has approved twice the sunscreens the US has: http://www.slate.com/articles/health_and_science/medical_exa... It's still true, we still don't have them. Obama even passed a law about it and it didn't help. > Based on your assertion and the data this means that you think all three of these agencies are harming the population, with the FDA being the lesser of all evils, by n…

Unless I'm missing something this is completely unrelated to and does not substantiate your argument that drug approvals are harming patients with the "mostly harming" argument implying more harm is being caused than prevented by current approval processes. Once again, source? > This is obviously true. As you only mentioned the FDA, and keep only mentioning the FDA, it is not obviously true that you are arguing again…

> Unless I'm missing something this is completely unrelated to and does not substantiate your argument that drug approvals are harming patients with the "mostly harming" argument implying more harm is being caused than prevented by current approval processes.

Not having sunscreen harms people by giving them skin cancer.

> As you only mentioned the FDA, and keep only mentioning the FDA, it is not obviously true that you are arguing against all Western drug approval agencies and not specifically the FDA.

I didn't say anything about them in my original post so I'm certainly open to believing they're also too slow.

Europeans certainly seem to believe a lot of strange things about American food that are just protectionism from their farmers.

> All being the same species does not mean all have the same regulatory framework and in fact they don't. I am sorry but I really don't understand any of the points you're trying to make.

Yeah but that's bad. It's also eg bad that every American city has completely different housing regulations.

Re: FDA Approves First Oral Treatment for Postpartum Depression

#155

Post by NoZebra120vClip »

mtlmtlmtlmtl wrote: post #150
xyzzy_plugh wrote: post #142

Since every top level comment here is a borderline tire fire, let me be the first to say: This is great news. We need better treatments for PPD, which is real and very serious that can cause long term lasting effects in serious cases without treatment, and can sadly even be fatal. Quality of life has risen steeply over the past several decades but mothers still walk an unpaved road. It's deeply worrying the lack of s…

Thank you. I'll never understand why there's such a dominance of luddite thinking, bad takes and conspiracy theories on HN, when it comes to the topic of mental health. Especially when it comes to drug treatments. Psychiatry no doubt has a lot of problems with it. But it's also the only game in town for a huge amount of people. What's the alternative? Prayer circles? Ayahuasca tourist traps? Cannabis? Homeopathy? Giv…

[flagged]

Re: FDA Approves First Oral Treatment for Postpartum Depression

#156

Post by haldujai »

afavour wrote: post #153
mtlmtlmtlmtl wrote: post #150

Earlier quoted context omitted.

Thank you. I'll never understand why there's such a dominance of luddite thinking, bad takes and conspiracy theories on HN, when it comes to the topic of mental health. Especially when it comes to drug treatments. Psychiatry no doubt has a lot of problems with it. But it's also the only game in town for a huge amount of people. What's the alternative? Prayer circles? Ayahuasca tourist traps? Cannabis? Homeopathy? Giv…

> I'll never understand why there's such a dominance of luddite thinking, bad takes and conspiracy theories on HN, when it comes to the topic of mental health I imagine there are many professional forums filled with people who know topic X inside out therefore assume they must also be an authority on unrelated topics Y and Z. But I also suspect there’s something about software engineering, perhaps the ability to succ…

It's insane to me that a group of educated and seemingly intelligent people seem to think they understand more about drug safety and prescribing than the FDA, researchers and physicians.

This is reminiscent of the Texas district judge who decided to controversially overrule the FDA on a medication safety decision that recently made the news, not good company one wants to have and I'm hoping is coincidental than suggestive of similar biases.

Re: FDA Approves First Oral Treatment for Postpartum Depression

#157

Post by lettergram »

xyzzy_plugh wrote: post #142

Since every top level comment here is a borderline tire fire, let me be the first to say: This is great news. We need better treatments for PPD, which is real and very serious that can cause long term lasting effects in serious cases without treatment, and can sadly even be fatal. Quality of life has risen steeply over the past several decades but mothers still walk an unpaved road. It's deeply worrying the lack of s…

It is / was common enough for women to have their placentas ground up and consumed via a pill. It is supposed to help regulate the hormones

I can imagine something like this doing something similar.

Re: FDA Approves First Oral Treatment for Postpartum Depression

#158

Post by haldujai »

astrange wrote: post #154
haldujai wrote: post #152

Earlier quoted context omitted.

Unless I'm missing something this is completely unrelated to and does not substantiate your argument that drug approvals are harming patients with the "mostly harming" argument implying more harm is being caused than prevented by current approval processes. Once again, source? > This is obviously true. As you only mentioned the FDA, and keep only mentioning the FDA, it is not obviously true that you are arguing again…

> Unless I'm missing something this is completely unrelated to and does not substantiate your argument that drug approvals are harming patients with the "mostly harming" argument implying more harm is being caused than prevented by current approval processes. Not having sunscreen harms people by giving them skin cancer. > As you only mentioned the FDA, and keep only mentioning the FDA, it is not obviously true that y…

I'm not sure how to communicate this more clearly. I'll try one last time.

My only question to you is this, you said:

"The FDA mostly harms the population by not approving drugs fast enough."

Do you have a source that says on the whole the FDA harms more people by not approving drugs more quickly, MORE than any safety added by this process.

Please note this would mean a citation that has looked at MANY approvals and timelines while ALSO looking at rejections for potential harm and concluding that the process is more harmful than beneficial.

To explain to you why yours is insufficient, even if we accept that this ONE example has caused harms you have not addressed any potential safety issues that have been prevented in OTHER therapeutics by the long process, this may in fact be zero or less than the harms caused by delays but requires evaluation in order to draw the conclusion you are making.

Re: FDA Approves First Oral Treatment for Postpartum Depression

#159

Post by tsimionescu »

NoZebra120vClip wrote: post #155
mtlmtlmtlmtl wrote: post #150

Earlier quoted context omitted.

Thank you. I'll never understand why there's such a dominance of luddite thinking, bad takes and conspiracy theories on HN, when it comes to the topic of mental health. Especially when it comes to drug treatments. Psychiatry no doubt has a lot of problems with it. But it's also the only game in town for a huge amount of people. What's the alternative? Prayer circles? Ayahuasca tourist traps? Cannabis? Homeopathy? Giv…

[flagged]

This is completely and utterly wrong. Psychiatric treatment varies in effectiveness, but there are drugs like lithium which have a fast and marked effect on the diseases they treat (e.g. Bipolar disorder, a crippling illness if left untreated). Depression drugs are less effective overall than other psychiatric illnesses, but even these have proven clinical effects in huge double-blind trials.

You really should read up on the literature, or hang around some people with serious mental health problems before spewing such garbage.

Re: FDA Approves First Oral Treatment for Postpartum Depression

#160

Post by khazhoux »

lettergram wrote: post #157
xyzzy_plugh wrote: post #142

Since every top level comment here is a borderline tire fire, let me be the first to say: This is great news. We need better treatments for PPD, which is real and very serious that can cause long term lasting effects in serious cases without treatment, and can sadly even be fatal. Quality of life has risen steeply over the past several decades but mothers still walk an unpaved road. It's deeply worrying the lack of s…

It is / was common enough for women to have their placentas ground up and consumed via a pill. It is supposed to help regulate the hormones I can imagine something like this doing something similar.

Common? Citation (and barfbag) needed!
Post reply on HN