Reversing hearing loss with regenerative therapy

Post by hunter2_ » Fri, Apr 15, 2022, 9:45 PM UTC

biggieshellz wrote: post #122

hunter2_ wrote: post #75

Earlier quoted context omitted.

Have you played around with an equalizer (hardware or software, doesn't matter) that offers rather extreme adjustments like +15dB or more, to see if you can approximate a flat source+ear system? Or is your loss more like a brickwall filter than a 12dB/octave slope for example? I'm an audio engineer, not an audiologist, so I'm just shooting from the hip here as it's something I've been curious about in case I develop…

Please don't do this. This would work for a conductive hearing loss (ear drum or bones in your ear messed up, etc.) but not for a sensorineural hearing loss (like what you get from aging or from noise exposure). You need non-linear compression to compensate for loudness recruitment. At a basic level, when you have sensorineural hearing loss, soft sounds will sound way softer than they should (or be below the threshol…

Post by bsder » Fri, Apr 15, 2022, 9:57 PM UTC

JohnBooty wrote: post #95

gumby wrote: post #87

Earlier quoted context omitted.

> Although exciting, we also need to remember that translatability rates from animal models to humans is notoriously low, usually in the single digits for most therapeutic areas. This is true of humans as well -- there are plenty of programs that get interesting and clear results in Phase 2 (the dose ranging phase: essentially "what dosage is most efficacious") that die in Phase 3 (roughly: "OK, how does that dose re…

It's also hard to figure out just how the animal's hearing is improving (you can't simply ask) This seems relatively easy, right? Play a sound at a given frequency, associate it with a food reward. Like Pavlov's dog, but vary the frequency of the bell. Oversimplification obviously, and "easy" is extreme relative to all the other hard parts involved but that part seems very doable

Post by crackedbassoon » Fri, Apr 15, 2022, 10:30 PM UTC

gumby wrote: post #108

JohnBooty wrote: post #95

Earlier quoted context omitted.

It's also hard to figure out just how the animal's hearing is improving (you can't simply ask) This seems relatively easy, right? Play a sound at a given frequency, associate it with a food reward. Like Pavlov's dog, but vary the frequency of the bell. Oversimplification obviously, and "easy" is extreme relative to all the other hard parts involved but that part seems very doable

One sobering lesson from my time working in the life sciences is that everything is insanely complex and once you've isolated everything in your problem space into a small, relatively isolated set, you still end up with an insanely complex space. Essentially it's fractally complex.

Post by yesenadam » Fri, Apr 15, 2022, 10:35 PM UTC

vanderZwan wrote: post #135

maroonblazer wrote: post #39

The article says the treatment focuses on increased speech intelligibility. Speech, depending on how you define it, can occupy a fairly narrow range of the audio spectrum that humans can perceive. My hearing loss is mostly on the high end (10-12K and above) and impedes my ability to hear speech in noisy environments. More troubling has been the inability to enjoy music/sound in those upper ranges, resulting in the mu…

I have sudden deafness in my left ear (meaning: I just woke up deaf one day and they don't know why) in exactly the frequency range used for speech. Even more than a decade later it feels weird that I can still hear certain common background noises but humans are almost completely silent on my left side

Post by crackedbassoon » Fri, Apr 15, 2022, 10:42 PM UTC

gumby wrote: post #87

Thebroser wrote: post #12

Earlier quoted context omitted.

“Animal research has shown that natural cochlear hair cell regeneration and resultant hearing restoration is very real” - Although exciting, we also need to remember that translatability rates from animal models to humans is notoriously low, usually in the single digits for most therapeutic areas. This is some cool tech, but just wanted to point it out that success in animal models =/= we will eventually get to see t…

> Although exciting, we also need to remember that translatability rates from animal models to humans is notoriously low, usually in the single digits for most therapeutic areas. This is true of humans as well -- there are plenty of programs that get interesting and clear results in Phase 2 (the dose ranging phase: essentially "what dosage is most efficacious") that die in Phase 3 (roughly: "OK, how does that dose re…