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Infection fatality rate of Covid-19 inferred from seroprevalence data [pdf]

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Re: Infection fatality rate of Covid-19 inferred from seroprevalence data [pdf]

#161
post #130
post #80

Earlier quoted context omitted.

We have a chance at eradicating COVID-19, unlike other viruses that have been endemic for decades.

How would we eradicate a virus that has animal hosts? If the prevailing origin hypothesis is correct then the virus is presumably still circulating among horseshoe bats.

SARS-1 has been eradicated in humans;its precursor still probably is circulating among bats.

Re: Infection fatality rate of Covid-19 inferred from seroprevalence data [pdf]

#162

The author, John Ioannidis, is a discredited researcher on Covid-19. He and his Stanford colleages are responsible for a terribly written antibody study done back in March on residents of Santa Clara County. The statistics in that paper were egregiously bad and seem cooked to meet foregone political conclusions. Some reporting: https://www.buzzfeednews.com/article/stephaniemlee/ioannidis... https://www.mercurynews.co…

I'm interested, but it seems like you'll need more than buzzfeed news as a source if you're claiming that Stanford scientists are unreliable.

Re: Infection fatality rate of Covid-19 inferred from seroprevalence data [pdf]

#163

The author, John Ioannidis, is a discredited researcher on Covid-19. He and his Stanford colleages are responsible for a terribly written antibody study done back in March on residents of Santa Clara County. The statistics in that paper were egregiously bad and seem cooked to meet foregone political conclusions. Some reporting: https://www.buzzfeednews.com/article/stephaniemlee/ioannidis... https://www.mercurynews.co…

This is a peer-reviewed article published by the World Health Organization, not a press release from an individual Stanford lab.

Could you please enumerate your specific concerns with this study?

Re: Infection fatality rate of Covid-19 inferred from seroprevalence data [pdf]

#164

For comparison, from what I've read the typical annual influenza fatality rate is around 0.1% (don't know what the under-70 rate would be). So, this puts covid-19 solidly in the uncanny valley of viral mortality rates; not low enough to be "just like a flu", not high enough to justify shutting down the world. No wonder opinions on it are so divided.

Daily reminder: new respitory diseases come and go, nobody usually cares. What makes Covid different and what caused the shutdowns was when Lombardy alone had 450 deaths a day. No regular influenza could do that. It's not as if we decided out of thin air the virus was dangerous.

> It's not as if we decided out of thin air the virus was dangerous.

But this is kind of exactly what we did. Go look at a yearly all-cause mortality chart going back the last 110 years. You’ll see this year is a noticeable but not so great uptick (of which many of the deaths will be overdoses, suicides, lack of medical treatment for preventable diseases etc btw). Whereas say the 1918 Flu pandemic was much more deadly in absolute and relative terms both.

Remember we’re talking about a disease that for many is so mild that they never realize they have it. For others like the very elderly it can be very bad, with a 5% chance of dying if infected, but it’s no surprise that surveys that ask people to estimate COVID-19 mortality show that on average people overestimate the fatality by between 10-100x.

SARS-2 is real, but the real virus really is in our minds. I hope one day you will come to see things my way too.

I also hope more commenters here will go mode out what happens when you perform universal rather than targeted mitigation measures: universal ends up with more mortality by slowing down infections in those who are not at risk, which delays hers immunity for almost no benefit.

Re: Infection fatality rate of Covid-19 inferred from seroprevalence data [pdf]

#165
post #4

For comparison, from what I've read the typical annual influenza fatality rate is around 0.1% (don't know what the under-70 rate would be). So, this puts covid-19 solidly in the uncanny valley of viral mortality rates; not low enough to be "just like a flu", not high enough to justify shutting down the world. No wonder opinions on it are so divided.

(1) A COVID-19 infection can have long-term effects even in young people. (2) We all have seen the images of hospitals overwhelmed with COVID-19 patients, not having enough breathers, etc. For some reason this doesn't happen with the typical annual influenza ... If you reduce everything to statistics about mortality rates, you are missing very important parts of the picture.

(1) is totally unproven speculation. We can’t even prove this happens for SARS-1 which per case is far more severe than SARS-2, its less deadly yet more infectious brother.

(2) absolutely does happen in bad flu seasons, and by the way most of those images are misleading or taken from prior years. Seriously. Even in say, New York, you’d have hospital A overflowing yet hospital B 10 miles away was at 30% capacity remaining. At least in the US a true overrun scenario never happened yet most don’t realize this.

You have to understand the role that mass collective delusion has played in our misguided response. And the media’s selective reporting doesn’t help.

Re: Infection fatality rate of Covid-19 inferred from seroprevalence data [pdf]

#166
post #38

As others say, this is way too much to say "meh", but I do think it needs a rethink of the lockdown strategies. Lockdowns kill people; people with cancer, people who need surgeries, people who lose income to support themselves. Clearly, so does Covid, and we need to balance it. Can we do better, as societies, if we aggressively protecting old and vulnerable people, and let fitter people continue with their lives? Thi…

The sad reality is that broad, indiscriminate lockdowns are the only real tool available to some "world powers". We know we can manage the covid pandemic with ubiquitous testing and targeted temporary lockdowns. But there is no testing capacity. Which means ... it's not really possible to rethink the lockdown strategies. Given a choice between a thing that directly kills people, and something that more people die fro…

One of the more... interesting things about Covid-19 is that the countries everyone thinks are stuck with indiscriminate lockdown as their only tool due to lack of testing capacity actually have the most testing capacity, and the one everyone points to as a mass testing success story has about an order of magnitude less in per capita terms and is likely severely limited in their ability to actually detect cases as a result. It's the result of cached facts from like 6 months ago that have never been refeshed because the media have carefully avoided drawing attention to the new information in order to preserve their narrative, whilst using language that leads people to think it's still true.

Re: Infection fatality rate of Covid-19 inferred from seroprevalence data [pdf]

#167
post #103

Earlier quoted context omitted.

That was always a risk even before COVID-19. Regular seasonal influenza can be deadly, especially to the elderly. Patients can transmit it to others when they are asymptomatic or presymptomatic. COVID-19 has a longer incubation period and a significantly higher fatality rate but the same fundamentals still apply. Any of us could have inadvertently killed someone by giving them the flu without even realizing it.

This is all true, but COVID hysteria has taken hold across the entire world, and HN is no exception unfortunately. You are being reflexively down voted because people view any comparison to Influenza as illegitimate, not realizing that you are making a broader point about risk management and attribution of blame for infection as opposed to saying that SARS-2 and Influenza are literally the same viruses. Personally I…

If you know you have the flu (or COVID-19), surely you know you are likely contagious and can spread it to more vulnerable people. Yes, it is your fault and you deserve blame if you knowingly spread it to others through negligence. Stay home if you're sick.

Re: Infection fatality rate of Covid-19 inferred from seroprevalence data [pdf]

#168
post #153

Earlier quoted context omitted.

There are beginning to be data on this available around well defined, young, and ultra healthy groups such as athletic leagues. Look within a given league at these long term effects / organ damage / health problems among those who recovered to rule out a lot of the self-selection or other variables. To some of your other points, the high end leagues are quite well medically documented, and the individuals are quite h…

"There are beginning to be data on this available around well defined, young, and ultra healthy groups such as athletic leagues. Look within a given league at these long term effects / organ damage / health problems among those who recovered to rule out a lot of the self-selection or other variables." I'm aware of one publication, which showed 4 athletes with heart-inflammation markers in a sample of 26 athletes: htt…

BTW I’m on mobile so didn’t re read that study but when I read the myocarditis study a month ago it turned out that the base rate of myocarditis was really no different than the COVID-19 rate and thus the whole scare was more or leas unfounded.

For studyi these supposed long-term effects I like to look at SARS-1 studies since we’ve had almost two decades. What we find is a few months of raidological ling abnormalities that heal, and mild cognitive deficits that linger for up to a year before disappearing completely. SARS-1 is miles worse than SARS-2 so the idea that young asymptomatic COVID-19 cases will end up with long term health problems is just completely farcical.

Unfortunately reading these studies requires a very critical lens. You showed that in your above comments but, for example, the person alleging these unproven and speculative long term impacts appears not to take that critical approach.

Re: Infection fatality rate of Covid-19 inferred from seroprevalence data [pdf]

#169
post #103

Earlier quoted context omitted.

That was always a risk even before COVID-19. Regular seasonal influenza can be deadly, especially to the elderly. Patients can transmit it to others when they are asymptomatic or presymptomatic. COVID-19 has a longer incubation period and a significantly higher fatality rate but the same fundamentals still apply. Any of us could have inadvertently killed someone by giving them the flu without even realizing it.

This is all true, but COVID hysteria has taken hold across the entire world, and HN is no exception unfortunately. You are being reflexively down voted because people view any comparison to Influenza as illegitimate, not realizing that you are making a broader point about risk management and attribution of blame for infection as opposed to saying that SARS-2 and Influenza are literally the same viruses. Personally I…

I can only speak for myself here, but COVID-19 has increased my awareness of the impact of flu season and I will endeavor to mitigate the risk of infecting others in the future. In the past, I hardly gave it a second thought—it never occurred to me that I could kill or harm someone by being careless (e.g. riding the metro to/from the climbing gym during flu season and indiscriminately spreading germs). Masks, giving people space, combining shopping trips, biking or driving, etc.—all are super easy ways to reduce potential harm to myself or others, so I’m more than happy to do these things as necessary going forward. There is no sense of fear or guilt, since I know I’ve done what I can reasonably do.

In that sense, I think comparing COVID-19 to the flu is helpful.

Re: Infection fatality rate of Covid-19 inferred from seroprevalence data [pdf]

#170

Earlier quoted context omitted.

> less than double your chances of dying in a year. The way this is phrased makes it sound like it's not a big deal. Doubling every individual's chance of dying within an entire generation is not something we should say lightly. Imagine if the base fatality rate was 50% rather than .5%.

Maybe I’m crazy, but I view doubling a chance of dying in a year, and then returning to normal mortality for the next year, as far preferable to mass business closures, suspension of civil liberties, pulling kids out of school without evidence, mandating everyone wear masks, etc. I guess I never realized how risk averse people apparently are. I imagine these same people never drive a car since those things are deatht…

[A]n English person aged 55–64 years who gets infected with SARS-CoV-2 faces a fatality risk that is more than 200 times higher than the annual risk of dying in a fatal car accident.

Assessing the Age Specificity of Infection Fatality Rates for COVID-19: Systematic Review, Meta-Analysis, and Public Policy Implications https://www.medrxiv.org/content/10.1101/2020.07.23.20160895v...

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