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GLP-1 drugs linked to lower death rates in colon cancer patients

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Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#141

Post by stavros »

dfc wrote: post #139
stavros wrote: post #44

Earlier quoted context omitted.

I can confirm that. On GLP-1s (when they worked for me, anyway), I'd routinely think "pizza? Bleh, so fatty, I'd really like some chicken breast with roast potatoes instead right now".

You can confirm that GLP1s make "carbs specifically disgusting" and an example of this reaction is that you would have a desire to eat potatoes?

Oh no, you have torn through the flaws in my argument like bullets through paper, however will I live this down? Unless I clearly meant "it makes previously-desirable food undesirable", anyway.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#142

Post by InMice »

l5870uoo9y wrote: post #140
InMice wrote: post #135

Earlier quoted context omitted.

Of course. That's why the nobel prize in medicine in 2016 was awarded to a cell biolgoist studying cellular autophagy for over a decade. It must be why glucose is not an essential dietary macronutrient and our liver can synthesizie it endogenously from fats and proteins (it just felt like doing that one day and stored all those chemical pathways in our genes I guess). That must also be why ketones produced from our f…

Took "water fasting" to mean fasting even without water, apparently it is the opposite.

LOL total misunderstanding then. No problem.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#143

Post by dfc »

stavros wrote: post #141
dfc wrote: post #139

Earlier quoted context omitted.

You can confirm that GLP1s make "carbs specifically disgusting" and an example of this reaction is that you would have a desire to eat potatoes?

Oh no, you have torn through the flaws in my argument like bullets through paper, however will I live this down? Unless I clearly meant "it makes previously-desirable food undesirable", anyway.

I was not trying to tear your argument down. The comment you replied to was about carbs being specifically disgusting and in my head potatoes are the runner up to bread for classic examples of carbs. I was simply asking about what seemed like a contradiction. I have been looking into GLP1s and have not seen/heard people mention that GLP1 make carbs gross.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#144

Post by aswegs8 »

surfsvammel wrote: post #59

I am on GLP-1 (very low dose), and I’ve found that it seems to help me moderate my alcohol consumption as well. Maybe some thing like that could also be contributing to the effect.

Does the very low dose help with weight management?

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#145

Post by dillydogg »

lm28469 wrote: post #24
radial_symmetry wrote: post #16

Earlier quoted context omitted.

Most medications have negative side effects because otherwise our bodies would already have whatever changes they make through evolution. My personal theory (based on nothing but my own intuition) is that GLP-1s are an adaptation to the modern world that evolution hasn't caught up with yet.

> Most medications have negative side effects because otherwise our bodies would already have whatever changes they make through evolution. That's not what evolution is, at all

This sounds like the argument during the pandemic, "If masks work, then why didn't we evolve permanent masks? Checkmate atheists." Though I do understand the impulse that evolution is working towards some unknowable perfection because of how I was taught evolution during high school, that is, of course, not how it works.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#146

Post by lazyasciiart »

InMice wrote: post #129
cyrusradfar wrote: post #81

Earlier quoted context omitted.

Agreed. I'm a big fan of intermittent and water fasting. Have seen things in my blood work that doctors would require me on meds to reverse. Outside of that, I can't speak to the positive impacts on my mood, and general ability to focus. The simplest solution to a lot of problems is consuming less with the assumption that, most of us (maybe not you), have a lot of spare energy sitting around. A lie that we don't unle…

ALmost everyone who shares their positive, any length fasting experience here gets downvoted. I will always upvote them. Ive done two 48 hour fasts and they were so relaxing and felt so natural. It just feels great to occasionally go about your day and not eat anything. Your gut tries to heal itself in between meals. The fact that almost all of HN just cant stand anyone mention they fast with positive benefits (and m…

If you include as much meta-commentary every time, you’re certainly going to get downvoted.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#147

Post by stavros »

dfc wrote: post #143
stavros wrote: post #141

Earlier quoted context omitted.

Oh no, you have torn through the flaws in my argument like bullets through paper, however will I live this down? Unless I clearly meant "it makes previously-desirable food undesirable", anyway.

I was not trying to tear your argument down. The comment you replied to was about carbs being specifically disgusting and in my head potatoes are the runner up to bread for classic examples of carbs. I was simply asking about what seemed like a contradiction. I have been looking into GLP1s and have not seen/heard people mention that GLP1 make carbs gross.

I think it varies per person. For me, it didn't specifically make carbs gross, but it did make unhealthy food less palatable. I think that's what the GP was talking about as well, they were just a bit more specific.

It really depends on the person, though. They worked for me for a while and don't work now, but I'm a small minority, from what I've heard from people. When they worked, they were great.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#148

Post by dillydogg »

CyanLite2 wrote: post #39
bicx wrote: post #2

Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.

Its not upside per se, more like avoiding the downsides of diabetes and obesity. Healthy, non-obese individuals likely aren't seeing these "benefits"... But I'm not a doctor, I just pretend to be one on the Internet.

This isn't true, the heart and kidney benefits appear independent of weight loss. I would encourage you to let the physicians speak to these effects instead of making educated conjecture; it is tough to keep ahead of all of the claims about these medications with my patients.

https://www.science.org/doi/10.1126/science.adn4128

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#149

Post by mannanj »

bicx wrote: post #2

Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.

Right. This is what we heard about the COVID therapies. And we all know how that turned out to be little more effective than placebo for healthy non-comorbid people.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#150

Post by foobarian »

Cthulhu_ wrote: post #128
cyrusradfar wrote: post #81

Earlier quoted context omitted.

Agreed. I'm a big fan of intermittent and water fasting. Have seen things in my blood work that doctors would require me on meds to reverse. Outside of that, I can't speak to the positive impacts on my mood, and general ability to focus. The simplest solution to a lot of problems is consuming less with the assumption that, most of us (maybe not you), have a lot of spare energy sitting around. A lie that we don't unle…

I for one don't "require" three meals a day, but I'm hungry in the morning, ergo, I like breakfast. It's not so much about how often you eat but what and how much. Generally speaking, of course, I can't speak for any benefits of intermittent fasting (assuming equal daily calorie / macronutrient intake) because I'm uneducated in that regard. But TL;DR, I will agree that desk jockeys will need less calories than people…

Maybe this goes away after a while, but when I tried this in the past I get so hungry I can't think or work. So clearly it's a non-starter for me on work days.
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