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Glucosamine Supplementation Reduces All-Cause Mortality: Study

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Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#141

Post by redka »

qwerty456127 wrote: post #96
evo_9 wrote: post #55

If you are interested in digging into this stuff, and what really works medically/scientifically based on reviewed evidence and sources such as Cochrane Reviews, I can't recommend Dr Stanfields youtube channel high enough: https://www.youtube.com/c/DrBradStanfield/videos Also here is his video on Sulforaphane which Glucosamine activates. He goes into detail as to how this mechanism works. Because of his video/latest…

Thank you for a very curious channel, I'm going to watch it all. Why does the doctor look so weird anyway? I mean his eyes - sort of a crazy gaze. Isn't he blind or something? Or is that an effect of a medication he takes?

he seems to never blink

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#142

Post by hhas01 »

hrishios wrote: post #140

This is an impossible field to be working in - I know - and it's to do with the way our medical research and treatment systems are set up. We began as a species focused on making sick people healthy, and it's the way the entire system works. It's near impossible to get studies approved that tackle aging and proactive healthcare with drugs, as they will largely need to look at the effects on people who are healthy now…

You do realize the reason people now die of dementia is because medical science and improved standards of living have largely eliminated all the things that used to kill them before they got old enough to develop it? The same goes for cancers.

As for heart disease, that’s largely a product of lifestyle choices: smoking, obesity, inactivity. And doctors already tell their patients to eat healthily and exercise daily, but who wants to hear that when they’re young enough not to feel the consequences, or old enough not to want to change their ways now?

Hence the eternal market for easy, quick magical pills and their silver-tongued salesmen that promise to cure it all.

We began as a species programmed to spot the difference between a zebra and lion on the plains of the Serengeti, and we’ve barely evolved since—if anything, we’re even easier to hack now. Just ask the vampires.

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#143

Post by GekkePrutser »

gootdude wrote: post #127
GekkePrutser wrote: post #62

I do indeed note that my minor (RSI related) joint issues almost immediately disappear when I take that stuff. It seems indeed quite beneficial.

What dosage do you take and how long does the pain relief last?

I take Glucosamine / Chondroitine Complex 500/100mg. One or 2 per day.

It's hard to say how long, it does take a day or 2 to kick in (when I said "immediately" I meant within a couple days when I start taking it. I probably shouldn't have used that term.)

I'm not very strict with medication so I tend to stop it when I don't have issues.

But especially in my elbows where I only have mild pain it seems to help a lot. In my wrists it doesn't as much, but I think the pain there is not totally joint-related.

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#144

Post by ranma42 »

hinkley wrote: post #126
mkl wrote: post #101

Earlier quoted context omitted.

Glucosamine tablets are made from natural sources, usually seafood (e.g. shells of shrimp, lobsters, and crabs).

I’ve heard that in japan (or at least parts of it) they eat shrimp whole, and it’s kind of amusing when visitors bite off the tails. Also the little “bones” from certain fish I expect do the same.

There's even snacks that are just the fried fish bones. http://seriouseats.com/2011/03/the-nasty-bits-fried-fish-bon...

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#145

Post by beagle3 »

Fezzik wrote: post #54

Like others, I give my dogs glucosamine and it seems to have clear health benefits, but I have tried numerous dosages for myself and when I consume any meaningful amount it gives me absolutely wretched headaches about a day or two after consumption. Something to be aware if you start taking glucosamine and get headaches, it’s probably the glucosamine.

Perhaps you have some undiagnosed shellfish allergy?

FWIW, I've noticed iHerb has started selling shellfish-free glucosamine.

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#146

Post by MMTP »

llama9000 wrote: post #128

The bit questioning its usefulness in addressing arthritis is pretty much bullshit, as it's working for my parents and even my cat - Who went from dragging himself around to going all jumpy within DAYS of having it mixed in with the food. Glucosamine + Chondrotin + MSM - This supplement combination is ideal.

The evidence for Glucosamine alone to do much about arthritis is poor. Glucosamine + Chondrotin + MSM is a different matter entirely and is not the same as what the author is speaking about.

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#147

Post by crdrost »

tmoertel wrote: post #89
Dayshine wrote: post #77

Earlier quoted context omitted.

Have you read the paper? They adjust for damn near everything including reverse causation. What confounders do you believe the UK biobank data can't account for?

Adjusting for the wrong confounders is one of the ways to create spurious correlations. For example, consider the causal system X -> Z in which X and Y are random coin tosses (heads=0, tails=1) and Z is their sum. Even though X and Y independent, they will be correlated if you control for Z. If you want to see it yourself, let's simulate this system in R: # Simulate 1000 trials in which X and Y are random coin tosses…

I do not know why you are simulating this system.

Given random x, y, controlling for z = x + y trivially generates a perfect anticorrelation as x = z – y.

Like, I get that you want to make a point, just seems weird to have a numerical solution in 5 lines of code to a problem that was already theoretically solved when you wrote down the problem statement and therefore required exactly 0 equations...?

Also like the theoretical solution clarifies that this happens for arbitrary probability distributions equally, it is not specific to Bernoulli random variables.

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#148

Post by oehtXRwMkIs »

ncmncm wrote: post #92
oehtXRwMkIs wrote: post #83

Earlier quoted context omitted.

It doesn't matter if you eliminate 10 million confounds. No matter how good your correlation study is, it cannot establish a causation. To do that you need random assignment at the very least.

... and even that gives you the wrong answer if your diagnostic specificity is faulty. This last is why we keep seeing muddled reports that "antidepressants don't work". Diagnosis of "depression" is a snakepit; the only known way to discern which among at least six conditions you might have, all labeled "depression", is to see what medications work, if any. Imagine trying to conduct a plausible RCT for that. "Gold st…

Did you reply to the wrong comment?

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#149

Post by ncmncm »

oehtXRwMkIs wrote: post #148
ncmncm wrote: post #92

Earlier quoted context omitted.

... and even that gives you the wrong answer if your diagnostic specificity is faulty. This last is why we keep seeing muddled reports that "antidepressants don't work". Diagnosis of "depression" is a snakepit; the only known way to discern which among at least six conditions you might have, all labeled "depression", is to see what medications work, if any. Imagine trying to conduct a plausible RCT for that. "Gold st…

Did you reply to the wrong comment?

I replied to "...it cannot establish a causation. To do that you need random assignment at the very least."

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#150

Post by nazca »

hlfy_hn wrote: post #90
nazca wrote: post #48

I've given glucosamine to my dogs for years, and I can clearly notice a difference in their joint health and how stiff and sore they are after long runs ('long-run': 15-25 miles, measured on GPS collars). When I run out of glucosamine, or just drop off of giving it to them for whatever reason, I see them fall back pretty quickly. And when I restart them on it, I notice a response in a few days. I also give give them…

Would you be so kind to tell me 1. The amount and frequency of glucosamine you give to your dog 2. The size of your dog (kg/pound)

I give 500mg per day. My two dogs are 55 and 65 lbs. The amazon product number I use is: B00V45IQF6. They have dosage info on the label for different sized dogs.
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