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Vibe coding my way to a healthy family: Introducing Gamow Labs

ddmckinnon.com

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Re: Vibe coding my way to a healthy family: Introducing Gamow Labs

#131

Post by fabbbbb »

mixdup wrote: post #104
onion2k wrote: post #64

Earlier quoted context omitted.

The point the OP is making is that given the choice parents will always choose a 100% 'perfect' child who will live a happy and long life free from things that make it difficult. Until relatively recently this hasn't actually been a choice though - as much as you'd like that, you've not been about to tell much about the long term future of a foetus so you got what Mother Nature blessed you with. Increasingly though,…

>The question is where that ends. Terminating due to a susceptibility to aggressive cancer? Maybe. Due to lower intelligence? Perhaps. Lower physical strength? Probability of autism? Unsymmetrical facial features (e.g. 'ugliness')? Why/how a pregnancy started (consensually or not for example) or the motivation behind making that choice (just don't want a kid, some genetic diagnosis, etc) are irrelevant. If abortion i…

Well the reasons for a choice do matter, don’t they? They matter in today’s law in many places.

Is aborting because of an LLM „likelihood“ of some genetic issue (that might lead or not lead to an short or unhappy life) the same as aborting after rape for you?

Biggest problem in fact is that people take genetic markers as deterministic and assume the worst outcome. Lots of false abortions happen. That does not happen with rape.

Re: Vibe coding my way to a healthy family: Introducing Gamow Labs

#132

Post by throwaw12 »

fabbbbb wrote: post #37
throwaw12 wrote: post #26

Earlier quoted context omitted.

> I’m skeptical that general purpose LLMs are a good fit for a very specialized medical analysis task If they can save more lives without harming other lives I would gladly take it during the analysis. Even saving 1% more lives is an amazing achievement!

How will this lead to saving lives? The only possible consequence is abortion?

in some cases early and correct diagnosis saves lives. may not be applicable for the OPs situation, but imagine running full diagnosis is so cheap at some point in the future that every kid when they born get that diagnosis cheaply and automatically. And doctors do not need to "guess" based on symptoms.

Re: Vibe coding my way to a healthy family: Introducing Gamow Labs

#133

Post by darkwater »

MattGrommes wrote: post #125
darkwater wrote: post #110

Earlier quoted context omitted.

Being an helicopter has a specific (and negative) meaning; caring and worrying for your kids seems just how many humans are wired.

The real difficulty is deciding what caring means. Some people decide caring means getting onto your adult child's job interview call because you think they need help. For others, caring means giving them a safety net but letting them learn and possibly fail on their own.

I might be opinionated but the former clearly feels/is a problematic and unhealthy behavior. The latter is much more reasonable.

Re: Vibe coding my way to a healthy family: Introducing Gamow Labs

#134

Post by mettamage »

bonsai_spool wrote: post #97
mettamage wrote: post #57

Earlier quoted context omitted.

Same. And the insight of having used LLMs and it being so capable is a wtf moment for me in itself. And I am an AI engineer. It’s my job to have a good idea about how far these models can take us.

> And the insight of having used LLMs and it being so capable is a wtf moment for me in itself. And I am an AI engineer. It’s my job to have a good idea about how far these models can take us. Are you saying that, as an 'AI engineer', you were unaware that LLMs could be used to interpret genetic variants? A thing that Google has been publishing on for well over 10 years?

Your comment seems too snarky. I am not having this discussion with you.

Re: Vibe coding my way to a healthy family: Introducing Gamow Labs

#135

Post by bonsai_spool »

mettamage wrote: post #134
bonsai_spool wrote: post #97

Earlier quoted context omitted.

> And the insight of having used LLMs and it being so capable is a wtf moment for me in itself. And I am an AI engineer. It’s my job to have a good idea about how far these models can take us. Are you saying that, as an 'AI engineer', you were unaware that LLMs could be used to interpret genetic variants? A thing that Google has been publishing on for well over 10 years?

Your comment seems too snarky. I am not having this discussion with you.

That’s quite fine, I hope it’s an opportunity for you to introspect

Re: Vibe coding my way to a healthy family: Introducing Gamow Labs

#136

Post by w0m »

darkwater wrote: post #133
MattGrommes wrote: post #125

Earlier quoted context omitted.

The real difficulty is deciding what caring means. Some people decide caring means getting onto your adult child's job interview call because you think they need help. For others, caring means giving them a safety net but letting them learn and possibly fail on their own.

I might be opinionated but the former clearly feels/is a problematic and unhealthy behavior. The latter is much more reasonable.

I ~never liked kids. I debated having them, then kind of settled on it (was planned). I expected to be be present but... aloof? Like my dad was.

Instead, I have buddies. I wouldn't call it unhealthy, just much more invested than I expected to be.

Re: Vibe coding my way to a healthy family: Introducing Gamow Labs

#137

Post by mixdup »

fabbbbb wrote: post #131
mixdup wrote: post #104

Earlier quoted context omitted.

>The question is where that ends. Terminating due to a susceptibility to aggressive cancer? Maybe. Due to lower intelligence? Perhaps. Lower physical strength? Probability of autism? Unsymmetrical facial features (e.g. 'ugliness')? Why/how a pregnancy started (consensually or not for example) or the motivation behind making that choice (just don't want a kid, some genetic diagnosis, etc) are irrelevant. If abortion i…

Well the reasons for a choice do matter, don’t they? They matter in today’s law in many places. Is aborting because of an LLM „likelihood“ of some genetic issue (that might lead or not lead to an short or unhappy life) the same as aborting after rape for you? Biggest problem in fact is that people take genetic markers as deterministic and assume the worst outcome. Lots of false abortions happen. That does not happen…

>Is aborting because of an LLM „likelihood“ of some genetic issue (that might lead or not lead to an short or unhappy life) the same as aborting after rape for you?

Yes. Because if you think it's wrong to end a pregnancy, what does it matter how it started or why you want to end it? The rationale behind being "pro-life" is that you feel abortion is killing a child. I happen to believe that a non-viable fetus is not a child, so I am supportive of a woman's right to manage her reproductive system as she so chooses, and therefore it doesn't matter why a woman wants to end a pregnancy--from rape or incest, doesn't want to have a child right now, doesn't want a child with a genetic deformity, or doesn't want a child with blonde hair--it doesn't matter.

On the other hand, if you felt that it was "murder" why would there be any reason good enough to justify murder? The only justifiable reason to kill another human being is in self-defense. A woman who was raped won't be "un-raped" because she is no longer carrying the baby. That sounds harsh, but of course I think it is BS because the whole anti-abortion argument is largely BS.

Re: Vibe coding my way to a healthy family: Introducing Gamow Labs

#138

Post by dmckinno »

331c8c71 wrote: post #102
dmckinno wrote: post #96

Earlier quoted context omitted.

It's funny you mention Dr. Kingsmore and Rady. While I am truly grateful for him and the team for their contributions to neonatal genetics (and hosting me in San Diego for a few days to show me how I could help), Rady was actually the unnamed lab that failed to diagnosis my son. And this happens all the time. The WGS NICU diagnostic rate is only ~30%, depending on who you ask. Just because people have been working at…

Thanks for the reply. I have read your post but I haven't seen the preprint obviously and without knowing the details I remain skeptical. > The WGS NICU diagnostic rate is only ~30%, depending on who you ask. Agreed. It does not automatically mean, however, that it can be significantly improved with better variant interpetation or better analysis of the same wgs data in general sense. > I'm planning on publishing eva…

OpenAI beat me to the punch in publishing on this, but my results are similar. I hope that these convince you :-)

https://openai.com/index/diagnose-rare-childhood-diseases/

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