I used a logitech mx mouse with the palm shape or whatever it's called and I realized that it stopped me from putting more of my hand on the desk, pin pointing the pressure of my hand onto the mouse instead of the desk. What helped dramatically was getting a smaller mouse without that thumb/palm shape (the logitech M720 Triathlon), that distributed more of the pressure onto my desk and I haven't had an issue since.
I hope that helps for anyone having similar ergonomic issues!