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Melatonin: Much More Than You Wanted to Know

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131–140 of 268 posts

Re: Melatonin: Much More Than You Wanted to Know

#131

When I was working long hours at an startup. My sleep cycle got disturbed. Here is what works for me: 1. Reduce room temperature to 25*C. Go to bed at 10:30pm 2. Automatically shutdown the airconditioner at 4:30am. 3. Jump out of bed at 5am without any alarm clock. This habit continues in the month when no airconditioner is needed.

Reduce the temperature to 25C? What do you normally keep it at?

Re: Melatonin: Much More Than You Wanted to Know

#132
post #44

What time should you take melatonin if you don't have any major sleep problems but want to improve sleep quality?

Roughly 30 minutes before I hit the pillow works for me. I use the normal melatonin (non-chews), but I suck on them till they dissolve in my mouth, because I hate when they get stuck in my epiglottis; you get used to the bitter flavor after a bit. I'm going to assume this is safe because chewables exist.

Why not just take it with a small amount of water?

Re: Melatonin: Much More Than You Wanted to Know

#133
post #91

Melatonin is usually not (freely) sold in Europe while it can be easily bought in the US like vitamin pills or cod liver oil. Is there a recommendable online option with international delivery? (I don't consider the usual 'online pharmacies' recommendable. Even when buying Melatonin in a store in the US, there's still the issue that Melatonin manufacturers and sellers mostly control themselves …)

Are you sure? It’s sold in every drug store in the Netherlands. I usually buy 500 tablets of 0.1 mg each.

Re: Melatonin: Much More Than You Wanted to Know

#134
post #42

Melatonin has also shown to help with certain cancers especially breast. Ref: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412427/

Some folks in the anti-aging community are taking it daily, not because they have trouble sleeping, but exactly because there seem to be a number of small health benefits of taking melaton8n that are not mediated by better sleeping.

Re: Melatonin: Much More Than You Wanted to Know

#135

From the article: >The consensus stresses that melatonin is a very weak hypnotic. The Buscemi meta-analysis cites this as their reason for declaring negative results despite a statistically significant effect – the supplement only made people get to sleep about ten minutes faster. “Ten minutes” sounds pretty pathetic, but we need to think of this in context. Even the strongest sleep medications, like Ambien, only sho…

I think your criticism is overstated. He's fairly clear about whether he's stating the result of a study, interpreting such results, or making an informed speculation. It's not cherry-picking if you're selecting the strongest competitors. The New York Times article is reporting on a meta-analysis by Buscemi et al, very similar to the one he discusses in a prior paragraph.

Re: Melatonin: Much More Than You Wanted to Know

#136
post #80

Melatonin has genuinely changed my life in regards to sleep. I'd tried everything and for exams went on Zopiclone, and then found the gold that is Melatonin. Thoroughly recommend anyone with suitable problems sleeping giving it a go. (I was DSPD, though every so often did the whole "Non-24-Hour-Sleep Disorder" thing)

How much do you take? I was regularly taking 3mg and 1.5mg regularly for most of the past 4 years. I recently tried 0.3mg (as recommended in another recent HN discussion about melatonin, I think it was a week or 2 ago), and I had terrible results. On 1.5mg and 3mg, I would have very unsettling and memorable dreams, as well as wake up very tired, but I would get at least 7 hours of sleep on most nights. With 0.3mg, I…

The article suggest the low dose but mid-day instead of right before bed.

Re: Melatonin: Much More Than You Wanted to Know

#137

Earlier quoted context omitted.

10,000 IU is the upper limit recommended by researchers, but afaik 4,000 is the more commonly accepted/advised number.

Wasn't there a recent study suggesting that the recommended daily value was off by a factor of ~10? I think an important thing to consider is that if your going to take large amounts of vitamin D, you should also be getting enough magnesium to prevent unhealthy calcification. In the winter, I've taken one time doses of ~40,000 IU every few weeks or so, (always in the morning of course). I remember reading that 40,000…

> I think an important thing to consider is that if your going to take large amounts of vitamin D, you should also be getting enough magnesium to prevent unhealthy calcification.

You should be taking vitamin K as well.

Re: Melatonin: Much More Than You Wanted to Know

#138

Magnesium is very important. Magnesium deficient rats were shown to have decreased melatonin. https://www.ncbi.nlm.nih.gov/m/pubmed/17172005/ It's also protective against hypercalcemia, so if you're taking vitamin D, make sure you're getting enough magnesium. I've even read that magnesium alone can mitigate the symptoms of vitamin D deficiency.

Magnesium is important, many people are deficient, supplementation is cheap and supplementation is very unlikely to cause harm (as long as you keep it to max 300 mg of elemental Mg (e.g. 2g of magnesium citrate) a day). Like with vitamin D, you should have very good reasons not to chose to take a magnesium supplement.

Is magnesium dissolved in water bioavailable? There are some sparkling mineral waters with Mg ions and it would be nice to be able to just sip on those

Re: Melatonin: Much More Than You Wanted to Know

#139

Earlier quoted context omitted.

10,000 IU is the upper limit recommended by researchers, but afaik 4,000 is the more commonly accepted/advised number.

Wasn't there a recent study suggesting that the recommended daily value was off by a factor of ~10? I think an important thing to consider is that if your going to take large amounts of vitamin D, you should also be getting enough magnesium to prevent unhealthy calcification. In the winter, I've taken one time doses of ~40,000 IU every few weeks or so, (always in the morning of course). I remember reading that 40,000…

I bought a magnesium spray but in reading up about absorption through the skin the evidence doesnt seem certain. Unless its getting absorbed through the rectum in a bath?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579607/

Re: Melatonin: Much More Than You Wanted to Know

#140

Earlier quoted context omitted.

Magnesium is important, many people are deficient, supplementation is cheap and supplementation is very unlikely to cause harm (as long as you keep it to max 300 mg of elemental Mg (e.g. 2g of magnesium citrate) a day). Like with vitamin D, you should have very good reasons not to chose to take a magnesium supplement.

Is magnesium dissolved in water bioavailable? There are some sparkling mineral waters with Mg ions and it would be nice to be able to just sip on those

I’m not sure. I know the bioavailability of magnesium citrate is much better than that of magnesium oxide, due to the bad solubility in water of the latter (and supplements with magnesium oxide are thus next to useless). That suggests Mg ions already present should be readily absorbed.
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