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Glucosamine Supplementation Reduces All-Cause Mortality: Study

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Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#121

Post by jiofih »

shadykiller wrote: post #73

Quote: "Glucosamine is a polysaccharide that is found naturally in cartilaginous joint tissues, bones, skin, ligaments, and nails" Why not just eat natural sources like cartilage, bone broth, skin etc ?

Interestingly most sources I could find on the web say categorically that “No natural food sources of glucosamine exist”, while the the supplement is made from sea shells. All resources related to canine health on the other hand mention cartilage, bone marrow and beef trachea as rich in glucosamine... someone is being dishonest there.

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#122

Post by 0d9eooo »

oehtXRwMkIs wrote: post #83
Dayshine wrote: post #77

Earlier quoted context omitted.

Have you read the paper? They adjust for damn near everything including reverse causation. What confounders do you believe the UK biobank data can't account for?

It doesn't matter if you eliminate 10 million confounds. No matter how good your correlation study is, it cannot establish a causation. To do that you need random assignment at the very least.

10 million confounds is a lot to eliminate. Randomization only works because it decreases the probability of a spurious association existing. At some point the number of confounds eliminated would probably be more worthwhile. I'd definitely pay more attention to a study that eliminated 10 million confounds than most randomized controlled trials.

I agree a randomized controlled trial would be nice now. But even that is potentially fraught. For example, someone else mentioned the possibility that glucosamine reduces joint pain, which increases mobility, which increases longevity. Randomizing wouldn't really control for that sort of scenario. And that's not even getting into preregistration, meta-analysis etc.

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#123

Post by dahinds »

m0llusk wrote: post #120
faitswulff wrote: post #108

Earlier quoted context omitted.

The study says the participants were 62% female, overwhelmingly ate more vegetables and supplements, exercised more than the control group, were mostly white, as well as self reported glucosamine supplementation - without dosage information. Overall it might be more indicative of wealth, education, and fitness than the effect of glucosamine. The paper itself says it’s not able to differentiate the effect from lifesty…

That is possible but the large sample size may help. The study involved roughly a half million people with around one hundred thousand supplementing with glucosamine. With that many people and these big numbers the results are rather strong.

In large studies, both true causal and true non-causal associations get stronger -- size gives no protection from confounding.

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#124

Post by jagannathtech »

tomcam wrote: post #115
lettergram wrote: post #113

Probably because those who are old start moving again with lower joint pain. My 80 year old grandfather is the most fit person I know. Super healthy, but literally lifts rocks and gardens every day. To contrast other family members are in their 50s with diabetes and heart conditions. Keeping active is key. Remove peoples joint pain (which is what this supplement is used for) and of course they reduce mortal across th…

Props to your grandfather. I can barely lift even a small garden.

lol

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#125

Post by jagannathtech »

jiofih wrote: post #121
shadykiller wrote: post #73

Quote: "Glucosamine is a polysaccharide that is found naturally in cartilaginous joint tissues, bones, skin, ligaments, and nails" Why not just eat natural sources like cartilage, bone broth, skin etc ?

Interestingly most sources I could find on the web say categorically that “No natural food sources of glucosamine exist”, while the the supplement is made from sea shells. All resources related to canine health on the other hand mention cartilage, bone marrow and beef trachea as rich in glucosamine... someone is being dishonest there.

Natural source means made by plants.

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#126

Post by hinkley »

mkl wrote: post #101
shadykiller wrote: post #73

Quote: "Glucosamine is a polysaccharide that is found naturally in cartilaginous joint tissues, bones, skin, ligaments, and nails" Why not just eat natural sources like cartilage, bone broth, skin etc ?

Glucosamine tablets are made from natural sources, usually seafood (e.g. shells of shrimp, lobsters, and crabs).

I’ve heard that in japan (or at least parts of it) they eat shrimp whole, and it’s kind of amusing when visitors bite off the tails.

Also the little “bones” from certain fish I expect do the same.

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#128

Post by llama9000 »

The bit questioning its usefulness in addressing arthritis is pretty much bullshit, as it's working for my parents and even my cat - Who went from dragging himself around to going all jumpy within DAYS of having it mixed in with the food.

Glucosamine + Chondrotin + MSM - This supplement combination is ideal.

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#129

Post by daodedickinson »

llama9000 wrote: post #128

The bit questioning its usefulness in addressing arthritis is pretty much bullshit, as it's working for my parents and even my cat - Who went from dragging himself around to going all jumpy within DAYS of having it mixed in with the food. Glucosamine + Chondrotin + MSM - This supplement combination is ideal.

Yes, we started giving Glycoflex to our dogs every day going back decades.

Re: Glucosamine Supplementation Reduces All-Cause Mortality: Study

#130

Post by hirenj »

I wonder why we need to supplement glucosamine (e.g. to treat arthritis) when it is synthesised by the body from glucose in one of our basic metabolic pathways. I could only imagine this becomes a problem unless a) the enzymes responsible stop working or b) if the glucose gets shunted off to some other purpose.

It’s also funny that chondroitin supplementation does the job too, because it actually contains no glucosamine, but contains monosaccharides that are derived from glucosamine (N-acetyl Galactosamine).

I think there’s probably a very interesting answer to these metabolic questions that could shed a lot of light onto the phenotypes of aging. That said, I don’t know what evidence is out there for systemic lack of e.g. glycosaminoglycans in aged populations, or even in arthritic cohorts.

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