Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

How long til we're all on Ozempic?

asteriskmag.com

Post reply on HN
Print view View original

111–120 of 1001 posts

Re: How long til we're all on Ozempic?

#111

Post by abeppu »

cyberax wrote: post #76
jeffbee wrote: post #67

Earlier quoted context omitted.

> Man, the garage is going to be clean and superbly organized in a few weeks.' Manic behaviors also associated with older, popular diet drugs like meth.

It's not the manic behavior, but the opposite. GLP-1 agonists appear to reduce the impulsive behavior.

Does anyone have references on any explanation, or even partial explanation, on why this might be the case?

The published stuff I can find seems to be at the level of anecdata, scarcely better than "I know a guy who..."

- What people talk about on social media: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669484/

- Some people made large "reckless" life choices: https://academic.oup.com/qjmed/advance-article-abstract/doi/...

Re: How long til we're all on Ozempic?

#112

Post by throwaway63467 »

zdragnar wrote: post #12
WheelsAtLarge wrote: post #2

Statins are regularly given to people with high cholesterol. I would bet that most older people take or qualify to take a statin. If it happens with statins, therefore, it's not out of the realm to think that most people will eventually be prescribed GLP-1 to reduce weight which will improve overall health. It makes sense.

Statins have gone through several prescribing guideline revisions in the last 10-20 years. Many people were incorrectly prescribed them and some have suffered for it. Likewise, there can be serious complications when taking GLP-1 agonists and the like. Since they need to be taken in perpetuity (many gain all weight lost upon stopping use) they should be reserved for only people who have exhausted all other opportunit…

I’m just back from the US and watching some TV there in the hotel it seems very much like they’re pushing it into the mainstream, they literally have a commercial where “fat” people congregate in the street to march together picking up Ozempic… So I totally assume it will be widespread in a few years unless they discover some serious side effects.

Re: How long til we're all on Ozempic?

#114

Post by akira2501 »

cyberax wrote: post #70
sss111 wrote: post #6

Earlier quoted context omitted.

There were several side effects related to pancreatic cancer associated with the precursors to GLP-1 drugs. The same companies promoting GLP-1s were responsible for driving up insulin prices. So I'm hedging my bets. There's a really cool Modern MBA video [1] on this topic btw :) [1]: https://www.youtube.com/watch?v=7sUoZVke_30

> There were several side effects related to pancreatic cancer In mice.

Were they humanized mice or not?

Re: How long til we're all on Ozempic?

#115

Post by amatecha »

dghlsakjg wrote: post #95
amatecha wrote: post #19

This article seems to frame things in such a strange way. Maybe instead of trying to get everyone obesity medication, we can instead educate society so we all understand nutrition and diet and can combat the ever-persistent forces of corporations pushing unhealthy food on us?

Do you think overweight people don't know why they're overweight? There are plenty of obese people that understand nutrition just fine, there are obese people who understand it well enough to have lost significant weight and gained it all back. Clearly there is something else going on that we haven't grasped yet.

Education may involve "finding a strategy that works for you". There are so, so many different ways to combat disordered eating. These are learnable things. My thought around "better education" is that the cycle of disordered eating can be stopped at some point before parents pass it on to their kids, at least (as I just posted in adjacent comment https://news.ycombinator.com/item?id=41811916 ). I absolutely recognize how insanely difficult it is to come back from disordered eating and stay at a lower weight after finally reaching it.

Though, now that you ask, I do think that many people don't actually know why they are overweight. They say it's because "McDonald's is cheaper than buying good food", not realizing the McDonalds won't satiate them and they will eat/spend more because their body is starved for proper nutrition. Watch the series "Supersize vs. Superskinny" and observe how nearly every participant is utterly clueless as to the underlying causes of their challenges on either size of the disordered-eating scale.

Re: How long til we're all on Ozempic?

#116

Post by Fauntleroy »

Spivak wrote: post #98
BoingBoomTschak wrote: post #28

Earlier quoted context omitted.

Well, the negative consequence on the value of willpower is pretty obvious. "In what measure" is the real question.

You have the completely wrong take on this. Dieting destroys your relationship with food. Basically every adult woman exhibits some level of disordered eating because of it— "girl dinner" is both funny because it's true and sad. Being able to lose weight while continuing to eat is a wonderful thing. There is no virtue in spending your willpower making your body do something it desperately doesn't want to do. That's s…

It doesn't make you magically lose weight, it just gets you closer to "girl dinnering" with less cognitive load. The weight loss comes from eating less.

Re: How long til we're all on Ozempic?

#117

Post by Blackthorn »

IncreasePosts wrote: post #3

My biggest fear is either there will be long term negative consequences to Ozempic et al, and a huge swath of the population will be dealing with issues 30 years form now - OR - there will be some long term positive consequence to using Ozempic et al, and I'm not getting any of the benefits because I'm not overweight.

Going by the results around addiction, I'm betting on #2 with reduced alcohol consumption.

Re: How long til we're all on Ozempic?

#118

Post by 2snakes »

dghlsakjg wrote: post #95
amatecha wrote: post #19

This article seems to frame things in such a strange way. Maybe instead of trying to get everyone obesity medication, we can instead educate society so we all understand nutrition and diet and can combat the ever-persistent forces of corporations pushing unhealthy food on us?

Do you think overweight people don't know why they're overweight? There are plenty of obese people that understand nutrition just fine, there are obese people who understand it well enough to have lost significant weight and gained it all back. Clearly there is something else going on that we haven't grasped yet.

Psychology of hunger behaviors.

Re: How long til we're all on Ozempic?

#119

Post by akira2501 »

setgree wrote: post #13

There's some evidence that Ozempic improves general impulse control, e.g decreasing alcohol consumption [0], which the article mentions. Also, as Tyler Cowen writes [1], this is probably going to translate into big improvements for animal welfare: > People lose weight on these drugs because they eat less, and eating less usually means eating less meat. And less meat consumption results in less factory farming. This s…

Eating animals and animal welfare are two entirely different things. We could all be vegetarians and still be intentionally or unintentionally intolerably cruel to all other life on this planet.

Re: How long til we're all on Ozempic?

#120

Post by k__ »

How are the side effects?

I read plastic surgeons said it was bad for your skin and people would look much older when they take it for a few months.

Yet, I also read it was generally good for your health, not just in terms of weight loss.

Post reply on HN