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Modafinil and Startups

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111–120 of 134 posts

Re: Modafinil and Startups

#111
post #88

Earlier quoted context omitted.

Contrary to what some doctors tell you, it is really hard to fix a Vitamin D deficiency with dietary supplements. Go to a tanning salon and get 250,000IUs in 10 minutes. Of course this is going to be a bit weird if you are naturally dark skinned, but far more effective than taking pills.

Citation? I ask because I'm interested in making sure I'm healthy, not to just be a jerk on the internet, and if that's true I'm doing something wrong.

Oral vitamin D is not taken up by the body all that well. If you do have a D deficiency and you're taking oral supplements, be sure to get your levels checked after 6 months. You may need to up your dose or get some direct sunlight.

Re: Modafinil and Startups

#112
post #68

It's worth noting that not everyone responds to modafinil. If you've had genetic sequencing done (I had mine done by 23andme), you can predict your response by checking your Rs4680 status. http://www.snpedia.com/index.php/Rs4680 rs4680(G;G) carriers deprived of sleep respond quite well to 2x 100mg modafinil in terms of improved vigor and well-being, and maintained baseline performance with respect to executive functi…

Contrary to what some doctors tell you, it is really hard to fix a Vitamin D deficiency with dietary supplements. Go to a tanning salon and get 250,000IUs in 10 minutes. Of course this is going to be a bit weird if you are naturally dark skinned, but far more effective than taking pills.

For me at least, this is certainly true. Even with significant dietary supplements and spending more time outside, I've only been able to get up to about 25 ng/mL. This is a significant improvement for me, as my initial levels were below the sensitivity of the test, at <0.25 ng/mL, but still not ideal. I hadn't considered visiting a tanning salon; I may try that soon if things aren't notably improved after the next time I get this tested.

Re: Modafinil and Startups

#113
I have heard it very difficult to get a prescription for Modafinil, even if you have work sleep shift disorder because most doctors aren't used to prescribing this drug.

Re: Modafinil and Startups

#114

I have taken 200mg of Modafinil daily for more than 5 years. Before it, I could go to sleep just about anywhere and just about any time. I could easily sleep for 12 to 14 hours a day if I let myself. When I had a work commute of about an hour and a half, I would have to pull over, sometimes four or five times, during the afternoon drive home to take cat naps because I couldn't keep my eyes open. It didn't matter how…

Your symptoms sound very similar to mine. I eventually had a large vitamin, neurotransmitter, hormone, and adrenal panel done, including saliva and urine samples throughout the day, and blood of course. I was severely deficient in vitamin D, very low cortisol, and notably low B12. Since starting to address these issues, my life has improved significantly. If you haven't had similar tests done, I encourage you to do so.

Re: Modafinil and Startups

#115

Stuff I've tried over the course of the last year or so: 1) Caffeine pills, 200mg each, around $4 at Walmart. I wrote about this before. The effects are far superior to coffee. More consistent, no intestinal distress. I could take one upon waking, and another around lunchtime. I haven't been taking them daily for a few months now, and my daytime productivity is certainly lower. 2) Piracetam with Choline Citrate and,…

Note that many 200mg caffeine pills are scored and can easily be split in half. You may find 100mg to be a better daily dosage; 200mg at once makes me too jittery.

Re: Modafinil and Startups

#116

I have taken 200mg of Modafinil daily for more than 5 years. Before it, I could go to sleep just about anywhere and just about any time. I could easily sleep for 12 to 14 hours a day if I let myself. When I had a work commute of about an hour and a half, I would have to pull over, sometimes four or five times, during the afternoon drive home to take cat naps because I couldn't keep my eyes open. It didn't matter how…

From as early as I can remember until about 14, I was a dangerously deep sleeper. I only sleep-walked a couple times, but there were times when I had extended, apparently-waking conversations with people, then had no recollection of them.

I could sleep through people talking, bouncing on the bed next to me, the TV, people clapping, etc. I would fall asleep any time I was not actively doing something. Sitting in class, sitting in the passenger seat of a car, anything where I wasn't actively thinking.

Around 14, I transitioned into symptoms like you describe here. I slept less heavily (though still very heavily) but I could sleep quite a bit, and in the afternoon, it would be willpower vs. drowsiness.

Around 18, I transitioned into what I now think of as a 26-hour day. Every day, I could not sleep until I was exhausted, which made me chase the clock around the day. This was obviously disruptive to work schedules and other normal social life.

Around 22, I transitioned into a pretty normal sleep schedule.

I don't know what changed in any of these cases.

Another oddity: I am able to regularly just not sleep at all, or sleep very little for days on end. I've been up for 72 hours dozens of times. It's quite clear that my functions decline, but 48 hours is not a big deal and longer is possible if there's some compelling reason.

Possibly related, my mother has had sleep problems here entire adult life, very rarely able to sleep more than 4 hours in a night.

I've never taken modafinil but have considered it quite a bit. I mostly think I shouldn't mess with it because I'm lucky enough to have a relatively normal sleep cycle now.

Re: Modafinil and Startups

#117
post #105

Hm, didn't expect to see this on Hacker News. Better copy over my comment from Reddit http://www.reddit.com/r/Nootropics/comments/q878x/modafinil_... : > Sure, you won't find studies of people who fried their neurons by using Modafinil for 10 years in a row, but that's because Modafinil isn't that old yet. Actually, it is. Even ignoring all the animal and French experiments etc, Cephalon got FDA approval and started…

> This is why blogs with no comments annoy me - how is the author supposed to find out that he made an obvious mistake?

Email? His site-wide byline is a mailto.

Re: Modafinil and Startups

#118
post #22

Modafinil is also compared to amphetamines (which are often used either for recreation or to treat ADHD), since its effect is somewhat similar. Generally, the comparison states that amphetamines are bad for you and that Modafinil is not as bad because it "works differently", but there is probably more overlap than the proponents of Modafinil would like you to think. There is one massively huge difference between amph…

I take Adderall, but not on the weekend. Always be careful when using phrases like "always" or "no one." I would not characterize myself as addicted to adderall either. Many times I have actually quit adderall and tried other ADHD medicines, but come back to adderall because it works better than the alternatives. My body seems to have no problem stopping or starting amphetamines.

[deleted]

Re: Modafinil and Startups

#119
post #101

Earlier quoted context omitted.

Actually, modafinil is practically tasteless, which I would say is objectively better than the bitter taste of coffee. Of course, it's possible to train yourself to enjoy that bitter taste through operant conditioning, but it's not really a "better" taste.

Or you could drink tea, which is tasty, and then you also get both caffeine and theanine.

Except that tea tastes terrible, and adding creamer and saccharine doesn't improve it as much as it does coffee. ;)

Re: Modafinil and Startups

#120
post #40
post #37

[deleted]

> I usually dose with a cocktail of piracetam, choline, and a small amount (100mg or so) of phenibut. Why?

I'm not the person who you directed your question to, but Piracetam and Choline help with increased cognition, focus, memory recall, and mental stamina. I haven't taken Phenibut, but it appears to reduce stress/anxiety.
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